PMID- 31093894
OWN - NLM
STAT- MEDLINE
DCOM- 20190722
LR  - 20200225
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 35
IP  - 7
DP  - 2019 Jul
TI  - T1 reactivity as an imaging biomarker in myocardial tissue characterization 
      discriminating normal, ischemic and infarcted myocardium.
PG  - 1319-1325
LID - 10.1007/s10554-019-01554-4 [doi]
AB  - To demonstrate the potential for differentiating normal and diseased myocardium 
      without Gadolinium using rest and stress T1-mapping. Patients undergoing 1.5T 
      magnetic resonance imaging (MRI) as part of clinical work-up due to suspicion of 
      coronary artery disease (CAD) were included. Adenosine stress perfusion MRI and 
      late gadolinium enhancement (LGE) imaging were performed to identify ischemic and 
      infarcted myocardium. Patients were retrospectively categorized into an ischemic, 
      infarct and control group based on conventional acquisitions. Patient with both 
      ischemic and infarcted myocardium were excluded. A total of 64 patients were 
      included: ten with myocardial ischemia, 15 with myocardial infarction, and 39 
      controls. A native Modified Look-Locker Inversion Recovery (MOLLI) T1-mapping 
      acquisition was performed at rest and stress. Pixel-wise myocardial T1-maps were 
      acquired in short-axis view with inline motion-correction. Short-axis T1-maps 
      were manually contoured using conservative septal sampling. Regions of interest 
      were sampled in ischemic and infarcted areas detected on perfusion and LGE 
      images. T1 reactivity was calculated as the percentage difference in T1 values 
      between rest and stress. Remote myocardium was defined as myocardium without 
      defects in the ischemic and infarcted group whereas normal myocardium is found in 
      the control group only. Native T1-values were significantly higher in infarcted 
      myocardium in rest and stress [median 1044 ms (interquartile range (IQR) 
      985-1076) and 1053 ms (IQR 989-1088)] compared to ischemic myocardium [median 
      961 ms (IQR 939-988) and 958 ms (IQR 945-988)]. T1-reactivity was significantly 
      lower in ischemic and infarcted myocardium [median 0.00% (IQR - 0.18 to 0.16) and 
      0.41% (IQR 0.09-0.86)] compared to remote myocardium [median 3.54% (IQR 
      1.48-5.78) and 3.21% (IQR 1.95-4.79)]. Rest-stress T1-mapping is able to 
      distinguish between normal, ischemic, infarcted and remote myocardium using 
      native T1-values and T1-reactivity, and holds potential as an imaging biomarker 
      for tissue characterization in MRI.
FAU - van Assen, Marly
AU  - van Assen M
AD  - Center for Medical Imaging, University Medical Center Groningen, University of 
      Groningen, Hanzeplein 1, EB 45, Groningen, The Netherlands.
AD  - Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands.
FAU - van Dijk, Randy
AU  - van Dijk R
AD  - Center for Medical Imaging, University Medical Center Groningen, University of 
      Groningen, Hanzeplein 1, EB 45, Groningen, The Netherlands.
FAU - Kuijpers, Dirkjan
AU  - Kuijpers D
AD  - Department of Cardiovascular Imaging, HMC-Bronovo, The Hague, The Netherlands.
FAU - Vliegenthart, Rozemarijn
AU  - Vliegenthart R
AD  - Center for Medical Imaging, University Medical Center Groningen, University of 
      Groningen, Hanzeplein 1, EB 45, Groningen, The Netherlands.
FAU - Oudkerk, Matthijs
AU  - Oudkerk M
AD  - Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands. 
      m.oudkerk@rug.nl.
AD  - Institute for Diagnostic Accuracy, Groningen, The Netherlands. m.oudkerk@rug.nl.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190515
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 0 (Vasodilator Agents)
RN  - K2I13DR72L (Gadolinium DTPA)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/administration & dosage
MH  - Aged
MH  - Contrast Media/administration & dosage
MH  - Coronary Artery Disease/*diagnostic imaging/pathology/physiopathology
MH  - Coronary Circulation
MH  - Diagnosis, Differential
MH  - Female
MH  - Gadolinium DTPA/administration & dosage
MH  - Hemodynamics
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging/pathology/physiopathology
MH  - Myocardial Ischemia/*diagnostic imaging/pathology/physiopathology
MH  - Myocardial Perfusion Imaging/*methods
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Tissue Survival
MH  - Vasodilator Agents/administration & dosage
PMC - PMC6598951
OTO - NOTNLM
OT  - Adenosine
OT  - CAD-coronary artery disease
OT  - Cardiac MR-cardiac magnetic resonance imaging
OT  - MOLLI-modified look-locker inversion
OT  - Native T1-mapping
COIS- All authors have reported that they have no relationships to disclose relevant to 
      this paper. The UMCG receives institutional research support from Siemens.
EDAT- 2019/05/17 06:00
MHDA- 2019/07/23 06:00
PMCR- 2019/05/15
CRDT- 2019/05/17 06:00
PHST- 2018/07/18 00:00 [received]
PHST- 2019/02/04 00:00 [accepted]
PHST- 2019/05/17 06:00 [pubmed]
PHST- 2019/07/23 06:00 [medline]
PHST- 2019/05/17 06:00 [entrez]
PHST- 2019/05/15 00:00 [pmc-release]
AID - 10.1007/s10554-019-01554-4 [pii]
AID - 1554 [pii]
AID - 10.1007/s10554-019-01554-4 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2019 Jul;35(7):1319-1325. doi: 
      10.1007/s10554-019-01554-4. Epub 2019 May 15.