PMID- 31094928
OWN - NLM
STAT- MEDLINE
DCOM- 20200409
LR  - 20200409
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 43
IP  - 9
DP  - 2019 Sep
TI  - Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic 
      Cell Carcinoma of the Salivary Glands.
PG  - 1264-1272
LID - 10.1097/PAS.0000000000001279 [doi]
AB  - Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] 
      enabling upregulation of the transcription factor Nuclear Receptor Subfamily 4 
      Group A Member 3 (NR4A3) through enhancer hijacking as the oncogenic driver event 
      in acinic cell carcinoma (AciCC) of the salivary glands. In the current study, we 
      evaluated the usefulness of NR4A3 immunostaining and NR4A3 fluorescence in situ 
      hybridization (FISH) in the differential diagnosis of AciCC, comparing a total of 
      64 AciCCs including 17% cases with high-grade transformation, 29 secretory 
      (mammary analog) carcinomas (MASC), and 70 other salivary gland carcinomas. 
      Nuclear NR4A3 immunostaining was a highly specific (100%) and sensitive (98%) 
      marker for AciCC with only 1 negative case, whereas NR4A3 FISH was less sensitive 
      (84%). None of the MASCs or other salivary gland carcinomas displayed any nuclear 
      NR4A3 immunostaining. The recently described HTN3-MSANTD3 gene fusion was 
      observed in 4 of 49 (8%) evaluable AciCCs, all with nuclear NR4A3 immunostaining. 
      In summary, NR4A3 immunostaining is a highly specific and sensitive marker for 
      AciCC, which may be especially valuable in cases with high-grade transformation 
      and in "zymogen granule"-poor examples within the differential diagnostic 
      spectrum of AciCC and MASC.
FAU - Haller, Florian
AU  - Haller F
AD  - Institute of Pathology.
FAU - Skalova, Alena
AU  - Skalova A
AD  - Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, 
      Czech Republic.
FAU - Ihrler, Stephan
AU  - Ihrler S
AD  - Dermpath Munich, Munich.
FAU - Markl, Bruno
AU  - Markl B
AD  - Institute of Pathology, Klinikum Augsburg.
FAU - Bieg, Matthias
AU  - Bieg M
AD  - Center for Digital Health, Berlin Institute of Health and 
      Charite-Universitatsmedizin Berlin, Berlin.
FAU - Moskalev, Evgeny A
AU  - Moskalev EA
AD  - Institute of Pathology.
FAU - Erber, Ramona
AU  - Erber R
AD  - Institute of Pathology.
FAU - Blank, Susanne
AU  - Blank S
AD  - Institute of Pathology.
FAU - Winkelmann, Christa
AU  - Winkelmann C
AD  - Institute of Pathology.
FAU - Hebele, Simone
AU  - Hebele S
AD  - Institute of Pathology.
FAU - Baneckova, Martina
AU  - Baneckova M
AD  - Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, 
      Czech Republic.
FAU - Wiemann, Stefan
AU  - Wiemann S
AD  - Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany.
FAU - Muller, Sarina
AU  - Muller S
AD  - Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital 
      Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen.
FAU - Zenk, Johannes
AU  - Zenk J
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Augsburg Clinic Center, 
      Augsburg.
FAU - Eils, Roland
AU  - Eils R
AD  - Center for Digital Health, Berlin Institute of Health and 
      Charite-Universitatsmedizin Berlin, Berlin.
FAU - Iro, Heinrich
AU  - Iro H
AD  - Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital 
      Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen.
FAU - Hartmann, Arndt
AU  - Hartmann A
AD  - Institute of Pathology.
FAU - Agaimy, Abbas
AU  - Agaimy A
AD  - Institute of Pathology.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NR4A3 protein, human)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Receptors, Thyroid Hormone)
SB  - IM
CIN - Am J Surg Pathol. 2019 Dec;43(12):1726-1728. PMID: 31414988
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Acinar Cell/*diagnosis
MH  - DNA-Binding Proteins/analysis/*biosynthesis
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Receptors, Steroid/analysis/*biosynthesis
MH  - Receptors, Thyroid Hormone/analysis/*biosynthesis
MH  - Salivary Gland Neoplasms/*diagnosis
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2019/05/17 06:00
MHDA- 2020/04/10 06:00
CRDT- 2019/05/17 06:00
PHST- 2019/05/17 06:00 [pubmed]
PHST- 2020/04/10 06:00 [medline]
PHST- 2019/05/17 06:00 [entrez]
AID - 10.1097/PAS.0000000000001279 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2019 Sep;43(9):1264-1272. doi: 10.1097/PAS.0000000000001279.