PMID- 31095610
OWN - NLM
STAT- MEDLINE
DCOM- 20200211
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 5
DP  - 2019
TI  - Prognostic factors and nomogram for cancer-specific death in non small cell lung 
      cancer with malignant pericardial effusion.
PG  - e0217007
LID - 10.1371/journal.pone.0217007 [doi]
LID - e0217007
AB  - BACKGROUND: The prognosis of lung cancer with malignant pericardial effusion is 
      very terrible owing to the impact of cardiac tamponade. The aim of our study 
      seeks to identify prognostic factors and establish a prognostic nomogram of non 
      small cell lung cancer (NSCLC) with malignant pericardial effusion. METHODS: 
      NSCLC patients with malignant pericardial effusion between 2010 and 2014 are 
      searched from SEER database.Cancer-specific death of these patients are analyzed 
      through the Kaplan-Meier method, Cox proportional hazard model and competing risk 
      model. Prognostic nomogram of cancer-specific death is performed and validated 
      with concordance index (C-index), calibration plots and internal validation 
      population. Propensity score matching is used to evaluate whether chemotherapy 
      affected the survival of study population. RESULTS: 696 eligible NSCLC patients 
      are involved in the study population, with 22.7% of 1-year survival rate and 8.9% 
      of 2-year survival rate. Laterality, AJCC N, AJCC T, and chemotherapy are 
      regarded as independent prognostic factors of cancer-specific death in the Cox 
      proportional hazards model and competing risk model. The C-index of established 
      nomogram is 0.703(95%CI:0.68-0.73) for cancer-specific death in the study 
      population with acceptable calibration, which is significantly higher than 
      classical TNM stage(C-index = 0.56, 95%CI:0.52-0.60). After 1:1 propensity score 
      matching, chemotherapy potentially reduces the risk of cancer-specific death (HR 
      = 0.42 95%CI: 0.31-0.58) of NSCLC with pericardial effusion. CONCLUSIONS: NSCLC 
      with malignant pericardial effusion harbors low overall survival. One prognostic 
      nomogram based on laterality, AJCC N, AJCC T and chemotherapy is developed for 
      cancer-specific death to predict 1-year and 2-year survival rate with good 
      performance.
FAU - Hu, Zhi Gang
AU  - Hu ZG
AUID- ORCID: 0000-0003-3421-0674
AD  - Department of Respiratory Medicine, Renmin Hospital of Wuhan University, Wuhan, 
      Hubei Province, People's Republic of China.
AD  - Department of Respiratory medicine, Respiratory Disease Research Institute of 
      China, Three Gorges University, Yichang, Hubei Province, People's Republic of 
      China.
FAU - Hu, Ke
AU  - Hu K
AD  - Department of Respiratory Medicine, Renmin Hospital of Wuhan University, Wuhan, 
      Hubei Province, People's Republic of China.
FAU - Li, Wen Xin
AU  - Li WX
AD  - Department of Respiratory medicine, Respiratory Disease Research Institute of 
      China, Three Gorges University, Yichang, Hubei Province, People's Republic of 
      China.
FAU - Zeng, Fan Jun
AU  - Zeng FJ
AD  - Department of Respiratory medicine, Respiratory Disease Research Institute of 
      China, Three Gorges University, Yichang, Hubei Province, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20190516
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Calibration
MH  - Carcinoma, Non-Small-Cell Lung/*diagnosis/*mortality/physiopathology
MH  - Cardiac Tamponade/complications/diagnosis
MH  - Cause of Death
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*diagnosis/*mortality/physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Nomograms
MH  - Pericardial Effusion/*diagnosis/*mortality/physiopathology
MH  - Prognosis
MH  - Propensity Score
MH  - Proportional Hazards Models
MH  - SEER Program
MH  - Survival Rate
MH  - Treatment Outcome
MH  - United States
PMC - PMC6521987
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/05/17 06:00
MHDA- 2020/02/12 06:00
PMCR- 2019/05/16
CRDT- 2019/05/17 06:00
PHST- 2018/10/29 00:00 [received]
PHST- 2019/05/02 00:00 [accepted]
PHST- 2019/05/17 06:00 [entrez]
PHST- 2019/05/17 06:00 [pubmed]
PHST- 2020/02/12 06:00 [medline]
PHST- 2019/05/16 00:00 [pmc-release]
AID - PONE-D-18-31204 [pii]
AID - 10.1371/journal.pone.0217007 [doi]
PST - epublish
SO  - PLoS One. 2019 May 16;14(5):e0217007. doi: 10.1371/journal.pone.0217007. 
      eCollection 2019.