PMID- 31099302
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2045-8932 (Print)
IS  - 2045-8940 (Electronic)
IS  - 2045-8932 (Linking)
VI  - 9
IP  - 2
DP  - 2019 Apr-Jun
TI  - Ventricular-ventricular interaction variables correlate with surrogate variables 
      of clinical outcome in children with pulmonary hypertension.
PG  - 2045894019854074
LID - 10.1177/2045894019854074 [doi]
LID - 2045894019854074
AB  - Determination of biventricular dimensions, function, and ventricular-ventricular 
      interactions (VVI) is an essential part of the echocardiographic examination in 
      adults with pulmonary hypertension (PH); however, data from according pediatric 
      studies are sparse. We hypothesized that left and right heart dimensions/function 
      and VVI variables indicate disease severity and progression in children with PH. 
      Left heart, right heart, and VVI variables (e.g. end-systolic LV eccentricity 
      index [LVEI], right ventricular [RV]/left ventricular [LV] dimension ratio) were 
      echocardiographically determined in 57 children with PH, and correlated with New 
      York Heart Association (NYHA) functional class (FC), N-terminal-pro brain 
      natriuretic peptide (NT-proBNP), and invasive hemodynamic variables (e.g. 
      pulmonary vascular resistance index [PVRi]). Clinically sicker patients (higher 
      NYHA FC) had lower LV ejection fraction (LVEF) and higher LVEI - a surrogate of 
      LV compression. In PH children, the ratio of systolic pulmonary arterial pressure 
      divided by systolic systemic arterial pressure (sPAP/sSAP) and the PVRi 
      correlated well with the LVEI ( P < 0.001). Patients with more severe PH 
      (sPAP/sSAP ratio, PVRi) had increased RV/LV and right-to-left atrial dimension 
      ratios ( P < 0.01). When stratified using NYHA-FC, sicker PH children had greater 
      RV and right atrial dimensions with lower exercise capacity, while the tricuspid 
      annular plane systolic excursion as surrogate for longitudinal systolic RV 
      function decreased. Consistent with previous studies, serum NT-proBNP correlated 
      with both, sPAP/sSAP ratio ( P < 0.001) and NYHA FC ( P < 0.01). Taken together, 
      the VVI variables LVEI and RV/LV dimension ratio are associated with lower FC, 
      worse hemodynamics, and higher NT-proBNP levels, thus highlighting the importance 
      of ventricular interdependence in pediatric PH.
FAU - Koestenberger, Martin
AU  - Koestenberger M
AUID- ORCID: 0000-0003-1766-7859
AD  - 1 Division of Pediatric Cardiology, Department of Pediatrics, Medical University 
      Graz, Austria.
AD  - 2 European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.
FAU - Sallmon, Hannes
AU  - Sallmon H
AD  - 2 European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.
AD  - 3 Department of Pediatric Cardiology, Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Avian, Alexander
AU  - Avian A
AD  - 4 Institute for Medical Informatics, Statistics and Documentation, Medical 
      University Graz, Austria.
FAU - Cantinotti, Massimiliano
AU  - Cantinotti M
AD  - 5 Fondazione CNR-Regione Toscana G. Monasterio, Massa and Pisa, Italy.
FAU - Gamillscheg, Andreas
AU  - Gamillscheg A
AD  - 1 Division of Pediatric Cardiology, Department of Pediatrics, Medical University 
      Graz, Austria.
AD  - 2 European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.
FAU - Kurath-Koller, Stefan
AU  - Kurath-Koller S
AD  - 1 Division of Pediatric Cardiology, Department of Pediatrics, Medical University 
      Graz, Austria.
AD  - 2 European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.
FAU - Schweintzger, Sabrina
AU  - Schweintzger S
AD  - 1 Division of Pediatric Cardiology, Department of Pediatrics, Medical University 
      Graz, Austria.
FAU - Hansmann, Georg
AU  - Hansmann G
AD  - 2 European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.
AD  - 6 Department of Pediatric Cardiology and Critical Care, Hannover Medical School, 
      Hannover, Germany.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pulm Circ
JT  - Pulmonary circulation
JID - 101557243
PMC - PMC6542130
OTO - NOTNLM
OT  - New York Health Association functional class
OT  - left ventricular eccentricity index
OT  - pediatric pulmonary hypertension
OT  - ventricular-ventricular interactions
EDAT- 2019/05/18 06:00
MHDA- 2019/05/18 06:01
PMCR- 2019/05/29
CRDT- 2019/05/18 06:00
PHST- 2019/05/18 06:00 [pubmed]
PHST- 2019/05/18 06:01 [medline]
PHST- 2019/05/18 06:00 [entrez]
PHST- 2019/05/29 00:00 [pmc-release]
AID - 10.1177_2045894019854074 [pii]
AID - 10.1177/2045894019854074 [doi]
PST - ppublish
SO  - Pulm Circ. 2019 Apr-Jun;9(2):2045894019854074. doi: 10.1177/2045894019854074.