PMID- 31100308
OWN - NLM
STAT- MEDLINE
DCOM- 20200220
LR  - 20200220
IS  - 1096-0007 (Electronic)
IS  - 0014-4835 (Linking)
VI  - 186
DP  - 2019 Sep
TI  - Elevated serum OxLDL is associated with progression of type 2 Diabetes Mellitus 
      to diabetic retinopathy.
PG  - 107668
LID - S0014-4835(18)30619-5 [pii]
LID - 10.1016/j.exer.2019.05.008 [doi]
AB  - Hyperlipidemia is associated with the progression of diabetic retinopathy (DR). 
      Paraoxonase 1 (PON1), an esterase is known to prevent systemic LDL oxidation. 
      This study assessed if serum oxLDL is associated with the progression of Type 2 
      DM to DR. This study is part of a three-year hospital based prospective study 
      where 87 subjects were recruited. This included T2DM without DR (n = 22); 
      Non-Proliferative (NPDR) (n = 21) and Proliferative DR (PDR) (n = 22) along with 
      age/sex matched controls (n = 22). Serum oxLDL-Ab was estimated by ELISA. Serum 
      PON esterase activity and plasma Malondialdehyde (MDA) level were estimated by 
      spectrophotometry and the serum Advanced Glycation End products (AGE) level by 
      spectroflourimetry. The systemic levels of oxLDL, AGE and MDA were increased with 
      the progression of T2DM without DR to DR as seen by ANOVA (P < 0.05). Serum 
      oxLDL-Ab levels showed a positive correlation to total cholesterol (P = 0.04) as 
      evaluated in the DR group. Statin intake was found to lower PON esterase activity 
      (P < 0.05). Based on this pilot study, it is proposed that elevated serum oxLDL 
      should be validated in larger cohort studies to ensure it could be potential risk 
      factor for the progression of T2DM to DR.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Kuppan, Kaviarasan
AU  - Kuppan K
AD  - Biochemistry and Cell Biology Department, Vision Research Foundation, Chennai, 
      600 006, India.
FAU - Mohanlal, Jithu
AU  - Mohanlal J
AD  - Biochemistry and Cell Biology Department, Vision Research Foundation, Chennai, 
      600 006, India.
FAU - Mohammad, Arif Mulla
AU  - Mohammad AM
AD  - Shri Bhagwan Mahavir Vitreo Retinal Services, Medical Research Foundation, 
      Chennai, 600 006, India.
FAU - Babu, Kannadasan Anand
AU  - Babu KA
AD  - Biochemistry and Cell Biology Department, Vision Research Foundation, Chennai, 
      600 006, India.
FAU - Sen, Parveen
AU  - Sen P
AD  - Shri Bhagwan Mahavir Vitreo Retinal Services, Medical Research Foundation, 
      Chennai, 600 006, India.
FAU - Undurti, Narasimha Das
AU  - Undurti ND
AD  - School of Biotechnology, Jawaharlal Nehru Technological University, Kakinada, 533 
      003, India.
FAU - Natarajan, Viswanathan
AU  - Natarajan V
AD  - Department of Biostatistics, Vision Research Foundation, Sankara Nethralaya, 
      Chennai, 600 006, India.
FAU - Narayanasamy, Angayarkanni
AU  - Narayanasamy A
AD  - Biochemistry and Cell Biology Department, Vision Research Foundation, Chennai, 
      600 006, India. Electronic address: drak@snmail.org.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20190514
PL  - England
TA  - Exp Eye Res
JT  - Experimental eye research
JID - 0370707
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Retinopathy/*blood
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Lipoproteins, LDL/*blood
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - AGE
OT  - Diabetic retinopathy
OT  - MDA
OT  - PON
OT  - T2DM
OT  - oxLDL
EDAT- 2019/05/18 06:00
MHDA- 2020/02/23 06:00
CRDT- 2019/05/18 06:00
PHST- 2018/08/19 00:00 [received]
PHST- 2019/03/30 00:00 [revised]
PHST- 2019/05/13 00:00 [accepted]
PHST- 2019/05/18 06:00 [pubmed]
PHST- 2020/02/23 06:00 [medline]
PHST- 2019/05/18 06:00 [entrez]
AID - S0014-4835(18)30619-5 [pii]
AID - 10.1016/j.exer.2019.05.008 [doi]
PST - ppublish
SO  - Exp Eye Res. 2019 Sep;186:107668. doi: 10.1016/j.exer.2019.05.008. Epub 2019 May 
      14.