PMID- 31101033
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20231115
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 20
IP  - 1
DP  - 2019 May 17
TI  - Minimal clinically important decline in physical function over one year: EPOSA 
      study.
PG  - 227
LID - 10.1186/s12891-019-2593-1 [doi]
LID - 227
AB  - BACKGROUND: The Australian/Canadian hand Osteoarthritis Index (AUSCAN) and the 
      Western Ontario and McMaster Universities knee and hip Osteoarthritis Index 
      (WOMAC) are the most commonly used clinical tools to manage and monitor 
      osteoarthritis (OA). Few studies have as yet reported longitudinal changes in the 
      AUSCAN index regarding the hand. While there are published data regarding WOMAC 
      assessments of the hip and the knee, the two sites have always evaluated 
      separately. The current study therefore sought to determine the minimal 
      clinically important difference (MCID) in decline in the AUSCAN hand and WOMAC 
      hip/knee physical function scores over 1 year using anchor-based and 
      distribution-based methods. METHODS: The study analysed data collected by the 
      European Project on Osteoarthritis, a prospective observational study 
      investigating six adult cohorts with and without OA by evaluating changes in the 
      AUSCAN and WOMAC physical function scores at baseline and 12-18 months later. 
      Pain and stiffness scores, the performance-based grip strength and walking speed 
      and health-related quality of life measures were used as the study's anchors. 
      Receiver operating characteristic curves and distribution-based methods were used 
      to estimate the MCID in the AUSCAN and WOMAC physical function scores; only the 
      data of those participants who possessed paired (baseline and follow up-measures) 
      AUSCAN and WOMAC scores were included in the analysis. RESULTS: Out of the 1866 
      participants who were evaluated, 1842 had paired AUSCAN scores and 1845 had 
      paired WOMAC scores. The changes in the AUSCAN physical function score correlated 
      significantly with those in the AUSCAN pain score (r = 0.31). Anchor- and 
      distribution-based approaches converged identifying 4 as the MCID for decline in 
      the AUSCAN hand physical function. Changes in the WOMAC hip/knee physical 
      function score were significantly correlated with changes in both the WOMAC pain 
      score (r = 0.47) and the WOMAC stiffness score (r = 0.35). The different 
      approaches converged identifying two as the MCID for decline in the WOMAC 
      hip/knee physical function. CONCLUSIONS: The most reliable MCID estimates of 
      decline over 1 year in the AUSCAN hand and WOMAC hip/knee physical function 
      scores were 4 and 2 points, respectively.
FAU - Siviero, Paola
AU  - Siviero P
AUID- ORCID: 0000-0001-6567-5808
AD  - National Research Council, Neuroscience Institute - Aging Branch, Via Giustiniani 
      2, ,35128, Padova, Italy. paola.siviero@in.cnr.it.
FAU - Limongi, Federica
AU  - Limongi F
AD  - National Research Council, Neuroscience Institute - Aging Branch, Via Giustiniani 
      2, ,35128, Padova, Italy.
FAU - Gesmundo, Antonella
AU  - Gesmundo A
AD  - Department of Medicine, University of Padova, Via 8 Febbraio 2, 35122, Padova, 
      Italy.
FAU - Zambon, Sabina
AU  - Zambon S
AD  - Department of Medicine, University of Padova, Via 8 Febbraio 2, 35122, Padova, 
      Italy.
FAU - Cooper, Cyrus
AU  - Cooper C
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General 
      Hospital, Tremona Road, Southampton, SO16 6YD, UK.
FAU - Dennison, Elaine M
AU  - Dennison EM
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General 
      Hospital, Tremona Road, Southampton, SO16 6YD, UK.
FAU - Edwards, Mark H
AU  - Edwards MH
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General 
      Hospital, Tremona Road, Southampton, SO16 6YD, UK.
AD  - Portsmouth Hospitals NHS Trust, Portsmouth, PO6 3LY, UK.
FAU - Timmermans, Erik J
AU  - Timmermans EJ
AD  - Department of Epidemiology and Biostatistics, Amsterdam UMC - location VU 
      University medical center, Amsterdam Public Health research institute, Amsterdam, 
      the Netherlands.
FAU - van der Pas, Suzan
AU  - van der Pas S
AD  - Department of Epidemiology and Biostatistics, Amsterdam UMC - location VU 
      University medical center, Amsterdam Public Health research institute, Amsterdam, 
      the Netherlands.
FAU - Schaap, Laura A
AU  - Schaap LA
AD  - Department of Epidemiology and Biostatistics, Amsterdam UMC - location VU 
      University medical center, Amsterdam Public Health research institute, Amsterdam, 
      the Netherlands.
FAU - van Schoor, Natasja M
AU  - van Schoor NM
AD  - Department of Epidemiology and Biostatistics, Amsterdam UMC - location VU 
      University medical center, Amsterdam Public Health research institute, Amsterdam, 
      the Netherlands.
FAU - Denkinger, Michael D
AU  - Denkinger MD
AD  - Bethesda Geriatric Clinic, University of Ulm, Zollernring 26, 89073, Ulm, 
      Germany.
FAU - Herbolsheimer, Florian
AU  - Herbolsheimer F
AD  - Institute of the History Philosophy and Ethics of Medicine, University of Ulm, 
      Frauensteige 6, 89075, Ulm, Germany.
FAU - Peter, Richard
AU  - Peter R
AD  - Institute of the History Philosophy and Ethics of Medicine, University of Ulm, 
      Frauensteige 6, 89075, Ulm, Germany.
FAU - Castell, Maria Victoria
AU  - Castell MV
AD  - Department of Preventive Medicine and Public Health, Unit of Primary Care and 
      Family Medicine, Faculty of Medicine, Universidad Autonoma de Madrid, Arzobispo 
      Morcillo 4, 28029, Madrid, Spain.
FAU - Otero, Angel
AU  - Otero A
AD  - Department of Preventive Medicine and Public Health, Unit of Primary Care and 
      Family Medicine, Faculty of Medicine, Universidad Autonoma de Madrid, Arzobispo 
      Morcillo 4, 28029, Madrid, Spain.
FAU - Queipo, Rocio
AU  - Queipo R
AD  - Department of Preventive Medicine and Public Health, Unit of Primary Care and 
      Family Medicine, Faculty of Medicine, Universidad Autonoma de Madrid, Arzobispo 
      Morcillo 4, 28029, Madrid, Spain.
FAU - Pedersen, Nancy L
AU  - Pedersen NL
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      P.O.Box 281, Nobels vag 12A, SE-171 77, Stockholm, Sweden.
FAU - Deeg, Dorly J H
AU  - Deeg DJH
AD  - Department of Epidemiology and Biostatistics, Amsterdam UMC - location VU 
      University medical center, Amsterdam Public Health research institute, Amsterdam, 
      the Netherlands.
FAU - Maggi, Stefania
AU  - Maggi S
AD  - National Research Council, Neuroscience Institute - Aging Branch, Via Giustiniani 
      2, ,35128, Padova, Italy.
CN  - EPOSA Research Group
LA  - eng
GR  - 19583/VAC_/Versus Arthritis/United Kingdom
GR  - MC_UU_12011/1/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A620_1014/MRC_/Medical Research Council/United Kingdom
GR  - MC_U147585827/MRC_/Medical Research Council/United Kingdom
GR  - MC_U147585824/MRC_/Medical Research Council/United Kingdom
GR  - G0400491/MRC_/Medical Research Council/United Kingdom
GR  - MC_U147585819/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Observational Study
DEP - 20190517
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthralgia/*diagnosis/etiology/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Hand Joints/physiopathology
MH  - Hip Joint/physiopathology
MH  - Humans
MH  - Knee Joint/physiopathology
MH  - Male
MH  - Osteoarthritis/complications/*diagnosis/physiopathology
MH  - Pain Measurement
MH  - *Physical Functional Performance
MH  - Prospective Studies
MH  - Quality of Life
MH  - *Severity of Illness Index
MH  - Surveys and Questionnaires/statistics & numerical data
PMC - PMC6525447
OTO - NOTNLM
OT  - AUSCAN
OT  - Functional decline
OT  - Hand
OT  - Hip/knee
OT  - MCID
OT  - Osteoarthritis
OT  - WOMAC
COIS- CC: consultancy, lecture fees and honoraria from Alliance for Better Bone Health, 
      Amgen, Eli Lilly, GSK, Medtronic, Merck, Novartis, Pfizer, Roche, Servier, 
      Takeda, and UCB (less than $ 10,000 each). ED: speaking fees from Eli Lilly (less 
      than $ 10,000). No competing interests were reported by the other authors.
FIR - Nikolaus, T
IR  - Nikolaus T
FIR - Peter, R
IR  - Peter R
FIR - Denkinger, M D
IR  - Denkinger MD
FIR - Herbolsheimer, F
IR  - Herbolsheimer F
FIR - Maggi, S
IR  - Maggi S
FIR - Zambon, S
IR  - Zambon S
FIR - Limongi, F
IR  - Limongi F
FIR - Noale, M
IR  - Noale M
FIR - Siviero, P
IR  - Siviero P
FIR - Deeg, D J
IR  - Deeg DJ
FIR - van der Pas, S
IR  - van der Pas S
FIR - Schaap, L A
IR  - Schaap LA
FIR - van Schoor, N M
IR  - van Schoor NM
FIR - Timmermans, E J
IR  - Timmermans EJ
FIR - Otero, A
IR  - Otero A
FIR - Castell, M V
IR  - Castell MV
FIR - Sanchez-Martinez, M
IR  - Sanchez-Martinez M
FIR - Quieipo, R
IR  - Quieipo R
FIR - Pedersen, N L
IR  - Pedersen NL
FIR - Broumandi, R
IR  - Broumandi R
FIR - Dennison, E M
IR  - Dennison EM
FIR - Cooper, C
IR  - Cooper C
FIR - Edwards, M H
IR  - Edwards MH
FIR - Parsons, C
IR  - Parsons C
EDAT- 2019/05/19 06:00
MHDA- 2019/12/31 06:00
PMCR- 2019/05/17
CRDT- 2019/05/19 06:00
PHST- 2019/01/16 00:00 [received]
PHST- 2019/04/26 00:00 [accepted]
PHST- 2019/05/19 06:00 [entrez]
PHST- 2019/05/19 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2019/05/17 00:00 [pmc-release]
AID - 10.1186/s12891-019-2593-1 [pii]
AID - 2593 [pii]
AID - 10.1186/s12891-019-2593-1 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2019 May 17;20(1):227. doi: 10.1186/s12891-019-2593-1.