PMID- 31101413
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20210702
IS  - 1094-6950 (Print)
IS  - 1094-6950 (Linking)
VI  - 23
IP  - 1
DP  - 2020 Jan-Mar
TI  - Osteoporosis and Osteopenia Among Patients With Type 2 Diabetes Aged >/=50: Role of 
      Sex and Clinical Characteristics.
PG  - 29-36
LID - S1094-6950(18)30235-X [pii]
LID - 10.1016/j.jocd.2019.04.004 [doi]
AB  - INTRODUCTION/BACKGROUND: Although some studies have explored the association of 
      adiposity and life habits (such as smoking) with osteoporosis and osteopenia 
      among type 2 diabetes mellitus (T2DM) patients, the association between diabetic 
      clinical characteristics (especially hypoglycemic drug use) and 
      osteoporosis/osteopenia remains unclear. This study aimed to investigate the 
      relationship of clinical characteristics with osteoporosis and osteopenia among 
      T2DM patients by sex. METHODS: A total of 1222 T2DM patients aged >/=50 were 
      included in the present study. Information on demographic, anthropometric and 
      clinical characteristics was collected from medical records. Bone mineral density 
      was assessed by dual-energy X-ray absorptiometry densitometer. Multiple adjusted 
      logistic regression analyses were performed to estimate the odds ratio (OR) and 
      95% confidence interval (CI) of osteoporosis and osteopenia related to clinical 
      characteristics. RESULTS: Of all participants, the prevalence of osteoporosis and 
      osteopenia was 9.2% and 41.3%, respectively, and they were higher in females 
      (14.7% and 48.5%) than in males (2.8% and 33%). After adjustment for potential 
      confounders, the results showed that overweight (OR = 0.59; 95% CI, 0.42-0.81) 
      and obesity (OR = 0.35; 95% CI, 0.24-0.50) were related to decreased odds of 
      osteoporosis and osteopenia in both male and female T2DM patients, poor glycemic 
      control (OR = 1.63; 95% CI, 1.08-2.47) was associated with increased odds of 
      osteoporosis and osteopenia in males, and metformin treatment (OR = 0.65; 95% CI, 
      0.43-0.99) was associated with decreased odds of osteoporosis and osteopenia in 
      females. CONCLUSIONS: Better glycemic management and rational choice of 
      antidiabetic medication might be promising to prevent osteoporosis in T2DM 
      patients. Further longitudinal studies are warranted to explore the association 
      between antidiabetic treatment and osteoporosis.
CI  - Copyright (c) 2019 The International Society for Clinical Densitometry. Published 
      by Elsevier Inc. All rights reserved.
FAU - Xu, Hui
AU  - Xu H
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Wang, Zhida
AU  - Wang Z
AD  - NHC Key Laboratory of Hormones and Development (Tianjin Medical University), 
      Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University 
      Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin, China.
FAU - Li, Xuerui
AU  - Li X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Fan, Meijuan
AU  - Fan M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Bao, Cuiping
AU  - Bao C
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Yang, Rongrong
AU  - Yang R
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Song, Fei
AU  - Song F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Xu, Weili
AU  - Xu W
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China; Aging Research Center (ARC), Department 
      Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm 
      University, Stockholm, Sweden. Electronic address: xuweili@tmu.edu.cn.
FAU - Qi, Xiuying
AU  - Qi X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China. Electronic address: qixiuying@tmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190421
PL  - United States
TA  - J Clin Densitom
JT  - Journal of clinical densitometry : the official journal of the International 
      Society for Clinical Densitometry
JID - 9808212
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Density
MH  - Bone Diseases, Metabolic/epidemiology/*etiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Osteoporosis/epidemiology/*etiology
MH  - Prevalence
MH  - Risk Factors
MH  - Sex Factors
OTO - NOTNLM
OT  - Antidiabetic treatments
OT  - clinical characteristics
OT  - osteopenia
OT  - osteoporosis
OT  - type 2 diabetes mellitus
EDAT- 2019/05/19 06:00
MHDA- 2021/07/03 06:00
CRDT- 2019/05/19 06:00
PHST- 2018/11/28 00:00 [received]
PHST- 2019/04/13 00:00 [revised]
PHST- 2019/04/17 00:00 [accepted]
PHST- 2019/05/19 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2019/05/19 06:00 [entrez]
AID - S1094-6950(18)30235-X [pii]
AID - 10.1016/j.jocd.2019.04.004 [doi]
PST - ppublish
SO  - J Clin Densitom. 2020 Jan-Mar;23(1):29-36. doi: 10.1016/j.jocd.2019.04.004. Epub 
      2019 Apr 21.