PMID- 31101685
OWN - NLM
STAT- MEDLINE
DCOM- 20200803
LR  - 20221207
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 6
DP  - 2019 Jun 28
TI  - Potential protective effects of bilirubin following the treatment of neonatal 
      hypoxic-ischemic encephalopathy with hypothermia therapy.
LID - BSR20182332 [pii]
LID - 10.1042/BSR20182332 [doi]
AB  - Background: Therapeutic hypothermia (TH) is the standard therapy for 
      hypoxic-ischemic encephalopathy (HIE) and is associated with a wide range of 
      physiological changes. Objective: We re-evaluated the effects of HIE and TH on 
      bilirubin measurements following HIE in a center involved in the China cooling 
      randomized controlled trial (RCT). Methods: Serial serum bilirubin concentrations 
      measured during the first week of life were compared among the HIE + NT 
      (normothermia) group, HIE + TH treatment group and control group (without HIE). 
      Survivors of HIE were followed and assessed at approximately 2 years of age, and 
      the results were correlated with peak bilirubin levels during the first week of 
      life. Results: One hundred and thirty-eight infants were available for analysis. 
      Significantly lower bilirubin levels were recorded in the HIE + NT group than in 
      the controls (P<0.05). Significant differences were not observed among the 
      patients in the HIE + NT group (mild to severe) or between the HIE + TH group and 
      the HIE + NT group at any time point (P>0.05). The peak serum bilirubin 
      concentrations recorded at 96 h of age showed a good correlation with the results 
      of the Bayley Scales of Infant and Toddler Development, third edition (BSID-III) 
      (P=0.02). Conclusion: Bilirubin potentially exerts a neuroprotective effect 
      during the first week of life, and low temperature does not affect the possible 
      antioxidant function of bilirubin during TH following HIE.
CI  - (c) 2019 The Author(s).
FAU - Zou, Liangyan
AU  - Zou L
AD  - Department of Neonatology, Children's Hospital of Fudan University, Shanghai 
      201102, China.
FAU - Yuan, Hao
AU  - Yuan H
AD  - Department of Neonatology, Children's Hospital of Fudan University, Shanghai 
      201102, China.
FAU - Liu, Qing
AU  - Liu Q
AD  - Department of Neonatology, Children's Hospital of Fudan University, Shanghai 
      201102, China.
FAU - Lu, Chunmei
AU  - Lu C
AD  - Department of Neonatology, Children's Hospital of Fudan University, Shanghai 
      201102, China.
FAU - Wang, Laishuan
AU  - Wang L
AUID- ORCID: 0000-0002-4126-0701
AD  - Department of Neonatology, Children's Hospital of Fudan University, Shanghai 
      201102, China laishuanwang@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190604
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Neuroprotective Agents)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Asian People
MH  - Bilirubin/*blood
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Humans
MH  - Hypothermia, Induced/*methods
MH  - Hypoxia-Ischemia, Brain/blood/ethnology/*therapy
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Neuroprotective Agents/*blood
PMC - PMC6549084
OTO - NOTNLM
OT  - Bayley Scales
OT  - Therapeutic hypothermia
OT  - bilirubin
OT  - hypoxic-ischemic encephalopathy
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/05/19 06:00
MHDA- 2020/08/04 06:00
PMCR- 2019/06/04
CRDT- 2019/05/19 06:00
PHST- 2018/11/02 00:00 [received]
PHST- 2019/04/21 00:00 [revised]
PHST- 2019/05/07 00:00 [accepted]
PHST- 2019/05/19 06:00 [pubmed]
PHST- 2020/08/04 06:00 [medline]
PHST- 2019/05/19 06:00 [entrez]
PHST- 2019/06/04 00:00 [pmc-release]
AID - BSR20182332 [pii]
AID - 10.1042/BSR20182332 [doi]
PST - epublish
SO  - Biosci Rep. 2019 Jun 4;39(6):BSR20182332. doi: 10.1042/BSR20182332. Print 2019 
      Jun 28.