PMID- 31101774
OWN - NLM
STAT- MEDLINE
DCOM- 20190823
LR  - 20190823
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 288
DP  - 2019 Mar
TI  - [FIBROTIC MARKERS IN INFANTS WITH PYELONEPHRITIS].
PG  - 44-48
AB  - Goal of the study - estimation of the transforming growth factor ss1 and monocyte 
      chemoattractant protein-1 (MCP-1) in infants with pyelonephritis. It was found 
      that pyelonephritis against the background of vesicoureteral reflux is 
      accompanied by the high activity of the inflammatory process and increase of 
      serum monocyte chemoattractant protein-1 levels (2.5 times higher than in 
      children with primary pyelonephritis). A significant relationship between the 
      content of monocytic chemoattractant protein-1 and C-reactive protein (rxy=0,66, 
      small er, Cyrillic<0,01) in young children with pyelonephritis against the background of reflux 
      was established. Pyelonephritis against the background of vesicoureteral reflux 
      in young children is accompanied by an increase in the content of serum 
      transforming growth factor beta1 (TGF-beta1) which is 2,8 times higher, in comparison 
      with patients with primary pyelonephritis. The profibrotic marker increased as 
      the disease activity increased. In children of early age with pielonefritis on 
      the background of vesicoureteral reflux and the presence of genotype C-509capital ES, Cyrillic and 
      T+869capital TE, Cyrillic (65,02+/-6,74%) transforming growth factor beta1 (TGF beta1) gene the probability 
      of developing the disease is 4.48 times higher, compared to genotype of 
      T-509capital TE, Cyrillic+869capital ES, Cyrillic and 3.03 times higher compared to genotype S-509capital TE, Cyrillic and T+869capital ES, Cyrillic.
FAU - Tokarchuk, N
AU  - Tokarchuk N
AD  - Vinnytsya National Medical University N. Pirogov, Ukraine.
FAU - Vyzhga, Y
AU  - Vyzhga Y
AD  - Vinnytsya National Medical University N. Pirogov, Ukraine.
FAU - Tokarchuk, V
AU  - Tokarchuk V
AD  - Vinnytsya National Medical University N. Pirogov, Ukraine.
FAU - Garibeh, E
AU  - Garibeh E
AD  - Vinnytsya National Medical University N. Pirogov, Ukraine.
LA  - rus
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 9007-41-4 (C-Reactive Protein)
MH  - Biomarkers
MH  - C-Reactive Protein
MH  - *Chemokine CCL2/genetics
MH  - Child
MH  - Child, Preschool
MH  - Genotype
MH  - Humans
MH  - Infant
MH  - *Pyelonephritis/diagnosis/genetics
MH  - *Transforming Growth Factor beta1/genetics
MH  - *Vesico-Ureteral Reflux
EDAT- 2019/05/19 06:00
MHDA- 2019/08/24 06:00
CRDT- 2019/05/19 06:00
PHST- 2019/05/19 06:00 [entrez]
PHST- 2019/05/19 06:00 [pubmed]
PHST- 2019/08/24 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2019 Mar;(288):44-48.