PMID- 31102059
OWN - NLM
STAT- MEDLINE
DCOM- 20191223
LR  - 20191223
IS  - 1864-6433 (Electronic)
IS  - 0914-7187 (Linking)
VI  - 33
IP  - 8
DP  - 2019 Aug
TI  - Up-front F18-FDG PET/CT in suspected salivary gland carcinoma.
PG  - 554-563
LID - 10.1007/s12149-019-01362-9 [doi]
AB  - OBJECTIVE: To investigate whether a 18F-FDG PET/CT (PET/CT)-based diagnostic 
      strategy adds decisive new information compared to conventional imaging in the 
      evaluation of salivary gland tumours and the detection of cervical lymph node 
      metastases, distant metastases, and synchronous cancer in patients with salivary 
      gland carcinoma. METHODS: The study was a blinded prospective cohort study. Data 
      were collected consecutively through almost 3 years. All patients underwent 
      conventional imaging-magnetic resonance imaging (MRI) and chest X-ray (CXR)-in 
      addition to PET/CT prior to surgery. Final diagnosis was obtained by 
      histopathology. MRI/CXR and PET/CT were interpreted separately by experienced 
      radiologists and nuclear medicine physicians. Interpretation included evaluation 
      of tumour site, cervical lymph node metastases, distant metastases, and 
      synchronous cancer. RESULTS: Ninety-one patients were included in the study. 
      Thirty-three patients had primary salivary gland carcinoma and eight had cervical 
      lymph node metastases. With PET/CT, the sensitivity was 92% and specificity 29% 
      regarding tumour site. With MRI/CXR, the sensitivity and specificity were 90% and 
      26%, respectively. Regarding cervical lymph node metastases in patients with 
      salivary gland carcinoma, the sensitivity with PET/CT was 100% and with MRI/CXR 
      50%. PET/CT diagnosed distant metastases in five patients, while MRI/CXR detected 
      these in two patients. Finally, PET/CT diagnosed two synchronous cancers, whereas 
      MRI/CXR did not detect any synchronous cancers. CONCLUSIONS: Compared with 
      MRI/CXR PET/CT did not improve discrimination of benign from malignant salivary 
      gland lesions. However, PET/CT may be advantageous in primary staging and in the 
      detection of distant metastases and synchronous cancers.
FAU - Westergaard-Nielsen, Marie
AU  - Westergaard-Nielsen M
AUID- ORCID: 0000-0002-9348-7078
AD  - Department of ORL-Head and Neck Surgery and Audiology, Odense University 
      Hospital, J.B. Winslows Vej 4, 5000, Odense C, Denmark. 
      marie.westergaard.nielsen@rsyd.dk.
FAU - Rohde, Max
AU  - Rohde M
AD  - Department of ORL-Head and Neck Surgery and Audiology, Odense University 
      Hospital, J.B. Winslows Vej 4, 5000, Odense C, Denmark.
FAU - Godballe, Christian
AU  - Godballe C
AD  - Department of ORL-Head and Neck Surgery and Audiology, Odense University 
      Hospital, J.B. Winslows Vej 4, 5000, Odense C, Denmark.
FAU - Eriksen, Jesper G
AU  - Eriksen JG
AD  - Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, 
      Denmark.
FAU - Larsen, Stine Rosenkilde
AU  - Larsen SR
AD  - Department of Pathology, Odense University Hospital, Odense, Denmark.
FAU - Gerke, Oke
AU  - Gerke O
AD  - Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
FAU - Nguyen, Nina
AU  - Nguyen N
AD  - Department of Radiology, Odense University Hospital, Odense, Denmark.
FAU - Nielsen, Mie K
AU  - Nielsen MK
AD  - Department of Radiology, Odense University Hospital, Odense, Denmark.
FAU - Nielsen, Anne L
AU  - Nielsen AL
AD  - Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
FAU - Thomassen, Anders
AU  - Thomassen A
AD  - Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
FAU - Asmussen, Jon T
AU  - Asmussen JT
AD  - Department of Radiology, Odense University Hospital, Odense, Denmark.
FAU - Diaz, Anabel
AU  - Diaz A
AD  - Department of Radiology, Odense University Hospital, Odense, Denmark.
FAU - Hoilund-Carlsen, Poul Flemming
AU  - Hoilund-Carlsen PF
AD  - Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
FAU - Bjorndal, Kristine
AU  - Bjorndal K
AD  - Department of ORL-Head and Neck Surgery and Audiology, Odense University 
      Hospital, J.B. Winslows Vej 4, 5000, Odense C, Denmark.
LA  - eng
GR  - SDUSF-2016-13-(505)/Syddansk Universitet/
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190517
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - *Positron Emission Tomography Computed Tomography
MH  - Prospective Studies
MH  - Salivary Gland Neoplasms/*diagnostic imaging/pathology
MH  - Young Adult
OTO - NOTNLM
OT  - Diagnostic imaging
OT  - PET/CT
OT  - Salivary gland carcinoma
OT  - Salivary gland tumours
OT  - Staging
EDAT- 2019/05/19 06:00
MHDA- 2019/12/24 06:00
CRDT- 2019/05/19 06:00
PHST- 2019/03/25 00:00 [received]
PHST- 2019/04/30 00:00 [accepted]
PHST- 2019/05/19 06:00 [pubmed]
PHST- 2019/12/24 06:00 [medline]
PHST- 2019/05/19 06:00 [entrez]
AID - 10.1007/s12149-019-01362-9 [pii]
AID - 10.1007/s12149-019-01362-9 [doi]
PST - ppublish
SO  - Ann Nucl Med. 2019 Aug;33(8):554-563. doi: 10.1007/s12149-019-01362-9. Epub 2019 
      May 17.