PMID- 31102521 OWN - NLM STAT- MEDLINE DCOM- 20201214 LR - 20201214 IS - 1532-2092 (Electronic) IS - 1099-5129 (Linking) VI - 21 IP - 9 DP - 2019 Sep 1 TI - Agreement between gadolinium-enhanced cardiac magnetic resonance and electro-anatomical maps in patients with non-ischaemic dilated cardiomyopathy and ventricular arrhythmias. PG - 1392-1399 LID - 10.1093/europace/euz127 [doi] AB - AIMS: We sought to investigate the overlap between late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) and electro-anatomical maps (EAM) of patients with non-ischaemic dilated cardiomyopathy (NIDCM) and how it relates with the outcomes after catheter ablation of ventricular arrhythmias (VA). METHODS AND RESULTS: We identified 50 patients with NIDCM who received CMR and ablation for VA. Late gadolinium enhancement was detected in 16 (32%) patients, mostly in those presenting with sustained ventricular tachycardia (VT): 15 patients. Low-voltage areas (<1.5 mV) were observed in 23 (46%) cases; in 7 (14%) cases without evidence of LGE. Using a threshold of 1.5 mV, a good and partially good agreement between the bipolar EAM and LGE-CMR was observed in only 4 (8%) and 9 (18%) patients, respectively. With further adjustments of EAM to match the LGE, we defined new cut-off limits of median 1.5 and 5 mV for bipolar and unipolar maps, respectively. Most VT exits (12 out of 16 patients) were found in areas with LGE. VT exits were found in segments without LGE in two patients with VT recurrence as well as in two patients without recurrence, P = 0.77. In patients with VT recurrence, the LGE volume was significantly larger than in those without recurrence: 12% +/- 5.8% vs. 6.9% +/- 3.4%; P = 0.049. CONCLUSIONS: In NIDCM, the agreement between LGE and bipolar EAM was fairly poor but can be improved with adjustment of the thresholds for EAM according to the amount of LGE. The outcomes were related to the volume of LGE. CI - Published on behalf of the European Society of Cardiology. All rights reserved. (c) The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. FAU - Torri, Federica AU - Torri F AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. FAU - Czimbalmos, Csilla AU - Czimbalmos C AD - Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Bertagnolli, Livio AU - Bertagnolli L AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. FAU - Oebel, Sabrina AU - Oebel S AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. FAU - Bollmann, Andreas AU - Bollmann A AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. FAU - Paetsch, Ingo AU - Paetsch I AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. FAU - Jahnke, Cosima AU - Jahnke C AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. FAU - Arya, Arash AU - Arya A AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. FAU - Merkely, Bela AU - Merkely B AD - Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Hindricks, Gerhard AU - Hindricks G AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. FAU - Dinov, Borislav AU - Dinov B AD - Department of Electrophysiology, HELIOS Heart Center-University of Leipzig, Strumpellstrasse 39, Leipzig, Germany. AD - Leipzig Heart Institute (LHI), Leipzig, Germany. LA - eng PT - Journal Article PL - England TA - Europace JT - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology JID - 100883649 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adult MH - Aged MH - Cardiomyopathy, Dilated/*diagnostic imaging/physiopathology MH - Catheter Ablation MH - Contrast Media MH - Electrophysiologic Techniques, Cardiac/*methods MH - Female MH - Gadolinium MH - Humans MH - Magnetic Resonance Imaging/methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Tachycardia, Ventricular/*diagnostic imaging/physiopathology/surgery MH - Treatment Outcome MH - Ventricular Premature Complexes/*diagnostic imaging/physiopathology/surgery OTO - NOTNLM OT - Ablation OT - Cardiac magnetic resonance OT - Late gadolinium enhancement OT - Low-voltage areas OT - Ventricular tachycardia EDAT- 2019/05/19 06:00 MHDA- 2020/12/15 06:00 CRDT- 2019/05/19 06:00 PHST- 2018/09/16 00:00 [received] PHST- 2019/04/11 00:00 [accepted] PHST- 2019/05/19 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2019/05/19 06:00 [entrez] AID - 5491591 [pii] AID - 10.1093/europace/euz127 [doi] PST - ppublish SO - Europace. 2019 Sep 1;21(9):1392-1399. doi: 10.1093/europace/euz127.