PMID- 31102776
OWN - NLM
STAT- MEDLINE
DCOM- 20200825
LR  - 20200825
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 27
IP  - 8
DP  - 2019 Aug
TI  - The ratio adipsin/MCP-1 is strongly associated with structural changes and 
      CRP/MCP-1 with symptoms in obese knee osteoarthritis subjects: data from the 
      Osteoarthritis Initiative.
PG  - 1163-1173
LID - S1063-4584(19)30978-1 [pii]
LID - 10.1016/j.joca.2019.04.016 [doi]
AB  - OBJECTIVE: There is a need to identify reliable biomarkers that can predict knee 
      osteoarthritis (OA) progression. We investigated a panel of adipokines and some 
      related inflammatory factors alone and their ratios for their associative value 
      at assessing cartilage volume loss over time and symptoms in obese [High body 
      mass index (BMI)] and non-obese (Low BMI) OA subjects. DESIGN: Human OA serum was 
      from the Osteoarthritis Initiative Progression subcohort. Baseline levels of 
      adiponectin (high and low molecular weight forms), adipsin, chemerin, leptin, 
      visfatin, C-reactive protein (CRP), interleukin-8 (IL-8) and monocyte 
      chemoattractant protein-1 (MCP-1) were evaluated with specific assays. Cartilage 
      volume was assessed at baseline and 48 months by quantitative magnetic resonance 
      imaging (MRI), and symptoms using baseline Western Ontario and McMaster 
      Universities Osteoarthritis Index (WOMAC) scores. Data were analysed by linear 
      regression with confounding factors at baseline, followed by multiple comparison 
      adjustment. RESULTS: The levels of the nine biomarkers and their ratios (36) were 
      studied. Among High BMI subjects, only the ratio adipsin/MCP-1 was associated 
      with cartilage volume loss over time in the lateral compartment [beta, -2.95; 95% 
      confidence interval (CI), -4.42, -1.49; P = 0.010], whereas MCP-1 was associated 
      with WOMAC pain (-1.74; -2.75, -0.73; P = 0.030) and the ratio CRP/MCP-1 with 
      WOMAC pain (0.76; 0.37, 1.14; P = 0.023), function (2.43; 1.20, 3.67; P = 0.020) 
      and total (3.29; 1.58, 5.00; P = 0.027). No associations were found for 
      biomarkers or ratios in Low BMI OA. CONCLUSION: In this study, the ratio 
      adipsin/MCP-1 was found to be associated with the knee structural changes and 
      that of CRP/MCP-1 with symptoms in obese OA subjects. Our data further underline 
      the relevance of ratios as biomarkers to a stronger association to OA progression 
      and symptoms.
CI  - Copyright (c) 2019 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Martel-Pelletier, J
AU  - Martel-Pelletier J
AD  - Osteoarthritis Research Unit, University of Montreal Hospital Research Centre 
      (CRCHUM), Montreal, Quebec, Canada. Electronic address: jm@martelpelletier.ca.
FAU - Tardif, G
AU  - Tardif G
AD  - Osteoarthritis Research Unit, University of Montreal Hospital Research Centre 
      (CRCHUM), Montreal, Quebec, Canada. Electronic address: tardifgi@yahoo.com.
FAU - Rousseau Trepanier, J
AU  - Rousseau Trepanier J
AD  - Osteoarthritis Research Unit, University of Montreal Hospital Research Centre 
      (CRCHUM), Montreal, Quebec, Canada. Electronic address: jtrepanier@arthrolab.com.
FAU - Abram, F
AU  - Abram F
AD  - Medical Imaging Research & Development, ArthroLab Inc., Montreal, Quebec, Canada. 
      Electronic address: fabram@arthrovision.biz.
FAU - Dorais, M
AU  - Dorais M
AD  - StatSciences Inc., Notre-Dame-de-l'Ile-Perrot, Quebec, Canada. Electronic 
      address: marc.dorais.statsciences@gmail.com.
FAU - Raynauld, J-P
AU  - Raynauld JP
AD  - Osteoarthritis Research Unit, University of Montreal Hospital Research Centre 
      (CRCHUM), Montreal, Quebec, Canada. Electronic address: jp.raynauld@videotron.ca.
FAU - Pelletier, J-P
AU  - Pelletier JP
AD  - Osteoarthritis Research Unit, University of Montreal Hospital Research Centre 
      (CRCHUM), Montreal, Quebec, Canada. Electronic address: dr@jppelletier.ca.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190516
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.21.46 (Complement Factor D)
SB  - IM
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - C-Reactive Protein/*analysis
MH  - Cartilage, Articular/*diagnostic imaging
MH  - Chemokine CCL2/*blood
MH  - Complement Factor D/*analysis
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Obesity/epidemiology
MH  - Osteoarthritis, Knee/*diagnostic imaging/epidemiology
MH  - Pain Measurement
OTO - NOTNLM
OT  - Adipokines
OT  - Biomarkers
OT  - Inflammatory factors
OT  - Magnetic resonance imaging
OT  - Osteoarthritis
EDAT- 2019/05/19 06:00
MHDA- 2020/08/26 06:00
CRDT- 2019/05/19 06:00
PHST- 2018/10/09 00:00 [received]
PHST- 2019/04/18 00:00 [revised]
PHST- 2019/04/27 00:00 [accepted]
PHST- 2019/05/19 06:00 [pubmed]
PHST- 2020/08/26 06:00 [medline]
PHST- 2019/05/19 06:00 [entrez]
AID - S1063-4584(19)30978-1 [pii]
AID - 10.1016/j.joca.2019.04.016 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2019 Aug;27(8):1163-1173. doi: 
      10.1016/j.joca.2019.04.016. Epub 2019 May 16.