PMID- 31103383 OWN - NLM STAT- MEDLINE DCOM- 20201119 LR - 20201119 IS - 1557-3117 (Electronic) IS - 1053-2498 (Linking) VI - 38 IP - 8 DP - 2019 Aug TI - Predictors of survival in patients with not-operated chronic thromboembolic pulmonary hypertension. PG - 833-842 LID - S1053-2498(19)31474-3 [pii] LID - 10.1016/j.healun.2019.04.006 [doi] AB - BACKGROUND: Treatment options for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) have recently evolved with the availability of balloon pulmonary angioplasty (BPA) and pulmonary vasodilators. Our aim was to analyze the prognostic variables associated with long-term outcome in a cohort of patients with not-operated CTEPH. METHODS: From January 2006 to December 2016, 343 newly diagnosed consecutive patients with not-operated CTEPH were diagnosed and followed up in the French Reference Center for Pulmonary Hypertension. Overall long-term survival and prognostic factors according to the diagnosis period (early period, 2006-2012, vs recent period, since 2013, i.e., one year before availability of BPA) were analyzed. RESULTS: In the overall population, baseline New York Heart Association functional class, right atrial pressure, 6-minute walk distance (6MWD), and diagnosis period were independent predictors of survival. The 1- and 3-year survival rates of patients diagnosed in the recent period (n = 170) were 91.6% and 85.0%, compared with 89.0% and 74.3% in patients diagnosed in the early period (n = 173), respectively (p = 0.030). Multivariate analysis from patients diagnosed in the recent period found that baseline 6MWD (per 20 m increase in distance) (hazard ratio [HR], 0.879; 95% confidence interval [CI], 0.832-0.928, p < 0.001) and BPA (HR, 0.307; 95% CI, 0.099-0.957; p = 0.042) were independently associated with survival. CONCLUSIONS: Survival of not-operated patients with CTEPH has significantly improved in the recent management era. New treatment options, including BPA, might have the potential to improve the prognosis of patients with inoperable CTEPH. CI - Copyright (c) 2019 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. FAU - Taniguchi, Yu AU - Taniguchi Y AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Jais, Xavier AU - Jais X AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. Electronic address: xavier.jais@aphp.fr. FAU - Jevnikar, Mitja AU - Jevnikar M AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Boucly, Athenais AU - Boucly A AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Weatherald, Jason AU - Weatherald J AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; University of Calgary, Department of Medicine, Division of Respirology, Calgary, Canada; Libin Cardiovascular Institute of Alberta, Calgary, Canada. FAU - Brenot, Philippe AU - Brenot P AD - Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France; Service de Radiologie, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Planche, Olivier AU - Planche O AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France; AP-HP, Service de Radiologie, Hopital Bicetre, Le Kremlin-Bicetre, France. FAU - Parent, Florence AU - Parent F AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Savale, Laurent AU - Savale L AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Fadel, Elie AU - Fadel E AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France; Service de Chirurgie Thoracique, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Montani, David AU - Montani D AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Humbert, Marc AU - Humbert M AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Sitbon, Olivier AU - Sitbon O AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. FAU - Simonneau, Gerald AU - Simonneau G AD - Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin-Bicetre, France; AP-HP, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire, Hopital Bicetre, Le Kremlin-Bicetre, France; Inserm UMR-S 999, Hopital Marie Lannelongue, Le Plessis Robinson, France. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20190427 PL - United States TA - J Heart Lung Transplant JT - The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation JID - 9102703 SB - IM CIN - J Heart Lung Transplant. 2019 Aug;38(8):843-844. PMID: 31352999 MH - Aged MH - Aged, 80 and over MH - Angioplasty, Balloon MH - Chronic Disease MH - Female MH - Humans MH - Hypertension, Pulmonary/complications/*mortality/therapy MH - Male MH - Middle Aged MH - Prognosis MH - Pulmonary Embolism/complications/*mortality/therapy MH - Retrospective Studies MH - Survival Rate MH - Time Factors MH - Treatment Outcome OTO - NOTNLM OT - balloon pulmonary angioplasty OT - chronic thromboembolic pulmonary hypertension OT - medical therapy OT - prognosis OT - pulmonary endarterectomy OT - pulmonary vasodilators EDAT- 2019/05/20 06:00 MHDA- 2020/11/20 06:00 CRDT- 2019/05/20 06:00 PHST- 2018/11/26 00:00 [received] PHST- 2019/04/03 00:00 [revised] PHST- 2019/04/24 00:00 [accepted] PHST- 2019/05/20 06:00 [pubmed] PHST- 2020/11/20 06:00 [medline] PHST- 2019/05/20 06:00 [entrez] AID - S1053-2498(19)31474-3 [pii] AID - 10.1016/j.healun.2019.04.006 [doi] PST - ppublish SO - J Heart Lung Transplant. 2019 Aug;38(8):833-842. doi: 10.1016/j.healun.2019.04.006. Epub 2019 Apr 27.