PMID- 31103548
OWN - NLM
STAT- MEDLINE
DCOM- 20200302
LR  - 20200302
IS  - 2451-9030 (Electronic)
IS  - 2451-9022 (Linking)
VI  - 4
IP  - 7
DP  - 2019 Jul
TI  - Functional Connectivity Between Extrastriate Body Area and Default Mode Network 
      Predicts Depersonalization Symptoms in Major Depression: Findings From an A 
      Priori Specified Multinetwork Comparison.
PG  - 627-635
LID - S2451-9022(19)30076-X [pii]
LID - 10.1016/j.bpsc.2019.03.007 [doi]
AB  - BACKGROUND: Depersonalization/derealization disorder is a dissociative disorder 
      characterized by feelings of unreality and detachment from the self and 
      surroundings. Depersonalization/derealization disorder is classified as a primary 
      disorder, but depersonalization symptoms are frequently observed in mood and 
      anxiety disorders. In the context of major depressive disorder (MDD), 
      depersonalization symptoms are associated with greater depressive severity as 
      indexed by treatment resistance, inpatient visits, and duration of depressive 
      episodes. In the current investigation, we tested four network-based, 
      neural-functional hypotheses of depersonalization in MDD. These hypotheses were 
      framed in terms of functional relationships between 1) extrastriate body area and 
      default mode network (DMN); 2) hippocampus and DMN; 3) medial prefrontal cortex 
      and ventral striatum; and 4) posterior and anterior insular cortex. METHODS: We 
      conducted functional magnetic resonance imaging during resting state on 28 female 
      patients with MDD and 27 control subjects with no history of a psychiatric 
      disorder. Functional connectivity between seed and target regions as specified by 
      our network-level hypotheses was computed and correlated with scores on the 
      Cambridge Depersonalization Scale. We used a conservative, unbiased bootstrapping 
      procedure to test the significance of neural-behavioral correlations observed 
      under each of the four models tested. RESULTS: Of the four neural-functional 
      models of depersonalization symptoms tested, only the model proposing that 
      reduced connectivity between the extrastriate body area and DMN predicts higher 
      levels of depersonalization symptoms in MDD was confirmed. CONCLUSIONS: Our 
      results indicate that depersonalization/derealization disorder symptoms in 
      patients with depression are related to reduced functional connectivity between 
      brain regions that are proposed to support processing of body-related 
      (extrastriate body area) and autobiographical (DMN) information.
CI  - Copyright (c) 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Paul, Elisabeth R
AU  - Paul ER
AD  - Center for Social and Affective Neuroscience, Department of Clinical and 
      Experimental Medicine, Linkoping University, Linkoping, Sweden.
FAU - Farmer, Madison
AU  - Farmer M
AD  - Department of Industrial and Organizational Psychology, Roosevelt University, 
      Chicago, Illinois.
FAU - Kampe, Robin
AU  - Kampe R
AD  - Center for Social and Affective Neuroscience, Department of Clinical and 
      Experimental Medicine, Linkoping University, Linkoping, Sweden.
FAU - Cremers, Henk R
AU  - Cremers HR
AD  - Department of Clinical Psychology, University of Amsterdam, Amsterdam, The 
      Netherlands.
FAU - Hamilton, J Paul
AU  - Hamilton JP
AD  - Center for Social and Affective Neuroscience, Department of Clinical and 
      Experimental Medicine, Linkoping University, Linkoping, Sweden. Electronic 
      address: paul.hamilton@liu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190329
PL  - United States
TA  - Biol Psychiatry Cogn Neurosci Neuroimaging
JT  - Biological psychiatry. Cognitive neuroscience and neuroimaging
JID - 101671285
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - Cerebral Cortex/physiopathology
MH  - Corpus Striatum/physiopathology
MH  - Depressive Disorder, Major/complications/*physiopathology
MH  - Dissociative Disorders/complications/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Neural Pathways/physiopathology
MH  - Prefrontal Cortex/physiopathology
MH  - Sense of Coherence
OTO - NOTNLM
OT  - Default mode network
OT  - Depersonalization/derealization disorder
OT  - Extrastriate body area
OT  - Functional connectivity
OT  - Major depressive disorder
EDAT- 2019/05/20 06:00
MHDA- 2020/03/03 06:00
CRDT- 2019/05/20 06:00
PHST- 2018/12/12 00:00 [received]
PHST- 2019/03/13 00:00 [revised]
PHST- 2019/03/13 00:00 [accepted]
PHST- 2019/05/20 06:00 [pubmed]
PHST- 2020/03/03 06:00 [medline]
PHST- 2019/05/20 06:00 [entrez]
AID - S2451-9022(19)30076-X [pii]
AID - 10.1016/j.bpsc.2019.03.007 [doi]
PST - ppublish
SO  - Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jul;4(7):627-635. doi: 
      10.1016/j.bpsc.2019.03.007. Epub 2019 Mar 29.