PMID- 31105240
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2313-7673 (Electronic)
IS  - 2313-7673 (Linking)
VI  - 3
IP  - 3
DP  - 2018 Jul 23
TI  - Biomechanical Modeling of Human Skin Tissue Surrogates.
LID - 10.3390/biomimetics3030018 [doi]
LID - 18
AB  - Surrogates, which precisely simulate nonlinear mechanical properties of the human 
      skin at different body sites, would be indispensable for biomechanical testing 
      applications, such as estimating the accurate load response of skin implants and 
      prosthetics to study the biomechanics of static and dynamic loading conditions on 
      the skin, dermatological and sports injuries, and estimating the dynamic load 
      response of lethal and nonlethal ballistics. To date, human skin surrogates have 
      been developed mainly with materials, such as gelatin and polydimethylsiloxane 
      (PDMS), based on assumption of simplified mechanical properties, such as an 
      average elastic modulus (estimated through indentation tests), and Poisson's 
      ratio. In addition, pigskin and cowhides, which have widely varying mechanical 
      properties, have been used to simulate human skin. In the current work, a novel 
      elastomer-based material system is developed, which precisely mimics the 
      nonlinear stress-stretch behavior, elastic modulus at high and low strains, and 
      fracture strengths of the natural human skin at different body sites. The 
      manufacturing and fabrication process of these skin surrogates are discussed, and 
      mechanical testing results are presented.
FAU - Chanda, Arnab
AU  - Chanda A
AD  - Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, 
      USA. arc165@pitt.edu.
AD  - Department of Aerospace Engineering and Mechanics, University of Alabama, 
      Tuscaloosa, AL 35401, USA. arc165@pitt.edu.
LA  - eng
PT  - Journal Article
DEP - 20180723
PL  - Switzerland
TA  - Biomimetics (Basel)
JT  - Biomimetics (Basel, Switzerland)
JID - 101719189
PMC - PMC6352690
OTO - NOTNLM
OT  - anisotropy
OT  - hyperelastic
OT  - skin
OT  - surrogate
OT  - tissue
COIS- The author declares no conflict of interest.
EDAT- 2019/05/21 06:00
MHDA- 2019/05/21 06:01
PMCR- 2018/07/23
CRDT- 2019/05/21 06:00
PHST- 2018/06/12 00:00 [received]
PHST- 2018/07/16 00:00 [revised]
PHST- 2018/07/19 00:00 [accepted]
PHST- 2019/05/21 06:00 [entrez]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2019/05/21 06:01 [medline]
PHST- 2018/07/23 00:00 [pmc-release]
AID - biomimetics3030018 [pii]
AID - biomimetics-03-00018 [pii]
AID - 10.3390/biomimetics3030018 [doi]
PST - epublish
SO  - Biomimetics (Basel). 2018 Jul 23;3(3):18. doi: 10.3390/biomimetics3030018.