PMID- 31105266
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20210109
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 20
IP  - 8
DP  - 2019 Nov
TI  - Relationship between human leukocyte antigen alleles and risk of Kaposi's sarcoma 
      in Cameroon.
PG  - 684-689
LID - 10.1038/s41435-019-0077-9 [doi]
AB  - Several studies published to date report associations between human leukocyte 
      antigen (HLA) alleles and different types of Kaposi's Sarcoma (KS). However, 
      there is little concordance between the HLA alleles identified and the 
      populations studied. To test whether HLA alleles associate with KS in a 
      Cameroonian case-control study, we performed high-resolution HLA typing in KSHV 
      seropositive individuals. Among HIV-positive individuals, carriers of HLA-B*14:01 
      were at a significantly higher risk of AIDS-KS (p = 0.033). For HIV-negative 
      patients, a gene-wise comparison of allele frequencies identified the HLA-B 
      (p = 0.008) and -DQA1 (p = 0.002) loci as possible risk factors for endemic KS. 
      Our study provides additional understanding of genetic determinants of KS and 
      their implications in disease pathogenesis. Further validation of these findings 
      is needed to define the functional relevance of these associations.
FAU - Cornejo Castro, Elena M
AU  - Cornejo Castro EM
AUID- ORCID: 0000-0003-1480-1397
AD  - Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National 
      Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, 
      USA.
FAU - Morrison, Brian J
AU  - Morrison BJ
AD  - Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National 
      Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, 
      USA.
FAU - Marshall, Vickie A
AU  - Marshall VA
AD  - Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National 
      Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, 
      USA.
FAU - Labo, Nazzarena
AU  - Labo N
AD  - Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National 
      Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, 
      USA.
FAU - Miley, Wendell J
AU  - Miley WJ
AD  - Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National 
      Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, 
      USA.
FAU - Clements, Nathan
AU  - Clements N
AD  - Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National 
      Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, 
      USA.
FAU - Nelson, George
AU  - Nelson G
AD  - CCR Collaborative Bioinformatics Resource (CCBR), Center for Cancer Research, 
      NCI, Bethesda, MD, USA.
AD  - Advanced Biomedical Computational Science, Frederick National Laboratory for 
      Cancer Research, Frederick, MD, USA.
FAU - Ndom, Paul
AU  - Ndom P
AD  - SOCHIMO, Yaounde, Cameroon.
FAU - Stolka, Kristen
AU  - Stolka K
AD  - RTI International, Research Triangle Park, Triangle Park, NC, USA.
FAU - Hemingway-Foday, Jennifer J
AU  - Hemingway-Foday JJ
AD  - RTI International, Research Triangle Park, Triangle Park, NC, USA.
FAU - Abassora, Mahamat
AU  - Abassora M
AD  - SOCHIMO, Yaounde, Cameroon.
FAU - Gao, Xiaojiang
AU  - Gao X
AD  - Basic Science Program, Frederick National Laboratory for Cancer Research, 
      Frederick, MD, USA.
FAU - Smith, Jennifer S
AU  - Smith JS
AD  - University of California San Diego, San Diego, CA, USA.
FAU - Carrington, Mary
AU  - Carrington M
AUID- ORCID: 0000-0002-2692-2180
AD  - Basic Science Program, Frederick National Laboratory for Cancer Research, 
      Frederick, MD, USA.
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
FAU - Whitby, Denise
AU  - Whitby D
AD  - Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National 
      Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, 
      USA. whitbyd@mail.nih.gov.
LA  - eng
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - U01 AI069927/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20190520
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Cameroon
MH  - Case-Control Studies
MH  - Female
MH  - HIV Infections/complications
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Sarcoma, Kaposi/etiology/*genetics
PMC - PMC6864225
MID - NIHMS1044196
COIS- Conflict of interest The authors declare that they have no conflict of interest.
EDAT- 2019/05/21 06:00
MHDA- 2020/02/11 06:00
PMCR- 2019/11/29
CRDT- 2019/05/21 06:00
PHST- 2019/02/08 00:00 [received]
PHST- 2019/04/28 00:00 [accepted]
PHST- 2019/04/24 00:00 [revised]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/05/21 06:00 [entrez]
PHST- 2019/11/29 00:00 [pmc-release]
AID - 10.1038/s41435-019-0077-9 [pii]
AID - 10.1038/s41435-019-0077-9 [doi]
PST - ppublish
SO  - Genes Immun. 2019 Nov;20(8):684-689. doi: 10.1038/s41435-019-0077-9. Epub 2019 
      May 20.