PMID- 31105581
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 10
DP  - 2019
TI  - BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and 
      Response to Injury.
PG  - 455
LID - 10.3389/fphys.2019.00455 [doi]
LID - 455
AB  - The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal 
      development and modulating synaptic activity have been extensively studied and 
      well established. Equally important roles for this growth factor have been 
      uncovered in the cardiovascular system, through the examination of gene targeted 
      animals to define critical actions in development, and to the unexpected roles of 
      BDNF in modulating the response of the heart and vasculature to injury. Here we 
      review the compartmentally distinct realm of cardiac myocytes, vascular smooth 
      muscle cells, endothelial cells, and hematopoietic cells, focusing upon the 
      actions of BDNF to modulate contractility, migration, neoangiogenesis, apoptosis 
      and survival. These studies indicate that BDNF is an important growth factor 
      which directs the response of the cardiovascular system to acute and chronic 
      injury.
FAU - Kermani, Pouneh
AU  - Kermani P
AD  - Department of Medicine, Weill Cornell Medical College, New York, NY, United 
      States.
FAU - Hempstead, Barbara
AU  - Hempstead B
AD  - Department of Medicine, Weill Cornell Medical College, New York, NY, United 
      States.
AD  - Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, 
      United States.
LA  - eng
GR  - P01 HL046403/HL/NHLBI NIH HHS/United States
GR  - R01 NS030687/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20190426
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6498408
OTO - NOTNLM
OT  - BDNF
OT  - TrkB
OT  - cardiovascular system
OT  - myocardial infarction
OT  - myocyte
OT  - vascular injury
EDAT- 2019/05/21 06:00
MHDA- 2019/05/21 06:01
PMCR- 2019/04/26
CRDT- 2019/05/21 06:00
PHST- 2018/07/27 00:00 [received]
PHST- 2019/04/01 00:00 [accepted]
PHST- 2019/05/21 06:00 [entrez]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2019/05/21 06:01 [medline]
PHST- 2019/04/26 00:00 [pmc-release]
AID - 10.3389/fphys.2019.00455 [doi]
PST - epublish
SO  - Front Physiol. 2019 Apr 26;10:455. doi: 10.3389/fphys.2019.00455. eCollection 
      2019.