PMID- 31105585
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231011
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 10
DP  - 2019
TI  - Multifractal Desynchronization of the Cardiac Excitable Cell Network During 
      Atrial Fibrillation. II. Modeling.
PG  - 480
LID - 10.3389/fphys.2019.00480 [doi]
LID - 480
AB  - In a companion paper (I. Multifractal analysis of clinical data), we used a 
      wavelet-based multiscale analysis to reveal and quantify the multifractal 
      intermittent nature of the cardiac impulse energy in the low frequency range  less, similar 
      2Hz during atrial fibrillation (AF). It demarcated two distinct areas within the 
      coronary sinus (CS) with regionally stable multifractal spectra likely 
      corresponding to different anatomical substrates. The electrical activity also 
      showed no sign of the kind of temporal correlations typical of cascading 
      processes across scales, thereby indicating that the multifractal scaling is 
      carried by variations in the large amplitude oscillations of the recorded bipolar 
      electric potential. In the present study, to account for these observations, we 
      explore the role of the kinetics of gap junction channels (GJCs), in dynamically 
      creating a new kind of imbalance between depolarizing and repolarizing currents. 
      We propose a one-dimensional (1D) spatial model of a denervated myocardium, where 
      the coupling of cardiac cells fails to synchronize the network of cardiac cells 
      because of abnormal transjunctional capacitive charging of GJCs. We show that 
      this non-ohmic nonlinear conduction 1D modeling accounts quantitatively well for 
      the "multifractal random noise" dynamics of the electrical activity 
      experimentally recorded in the left atrial posterior wall area. We further 
      demonstrate that the multifractal properties of the numerical impulse energy are 
      robust to changes in the model parameters.
FAU - Attuel, Guillaume
AU  - Attuel G
AD  - Geometry and Statistics in Acquisition Data, Centre de Recherche INRIA, Talence, 
      France.
FAU - Gerasimova-Chechkina, Evgeniya
AU  - Gerasimova-Chechkina E
AD  - Laboratory of Physical Foundation of Strength, Institute of Continuous Media 
      Mechanics UB RAS, Perm, Russia.
FAU - Argoul, Francoise
AU  - Argoul F
AD  - Laboratoire Ondes et Matieres d'Aquitaine, Universite de Bordeaux, UMR 5798, 
      CNRS, Talence, France.
FAU - Yahia, Hussein
AU  - Yahia H
AD  - Geometry and Statistics in Acquisition Data, Centre de Recherche INRIA, Talence, 
      France.
FAU - Arneodo, Alain
AU  - Arneodo A
AD  - Laboratoire Ondes et Matieres d'Aquitaine, Universite de Bordeaux, UMR 5798, 
      CNRS, Talence, France.
LA  - eng
PT  - Journal Article
DEP - 20190424
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6492055
OTO - NOTNLM
OT  - atrial fibrillation
OT  - excitable cell network
OT  - intermittent dynamics
OT  - kinetics of gap junction channel
OT  - modeling
OT  - multifractal analysis
EDAT- 2019/05/21 06:00
MHDA- 2019/05/21 06:01
PMCR- 2019/04/24
CRDT- 2019/05/21 06:00
PHST- 2018/11/03 00:00 [received]
PHST- 2019/04/05 00:00 [accepted]
PHST- 2019/05/21 06:00 [entrez]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2019/05/21 06:01 [medline]
PHST- 2019/04/24 00:00 [pmc-release]
AID - 10.3389/fphys.2019.00480 [doi]
PST - epublish
SO  - Front Physiol. 2019 Apr 24;10:480. doi: 10.3389/fphys.2019.00480. eCollection 
      2019.