PMID- 31106003
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 9
IP  - 4
DP  - 2019
TI  - Long non-coding RNA LINC01133 mediates nasopharyngeal carcinoma tumorigenesis by 
      binding to YBX1.
PG  - 779-790
AB  - Recently, long non-coding RNAs (lncRNAs) have been reported as the vital 
      regulators of various cancers including nasopharyngeal carcinoma (NPC). An 
      increasing number of studies have suggested that lncRNA LINC01133 is dysregulated 
      and involved in human carcinogenesis. However, the roles of LINC01133 in NPC 
      remain largely unknown. In this work, we demonstrated that LINC01133 was 
      significantly downregulated in NPC tissues and cell lines. Loss and gain of 
      function experiments provided evidence that LINC01133 inhibited NPC cell 
      proliferation, invasion and migration both in vitro and in vivo. Besides, 
      Fluorescence in situ hybridization (FISH) assay was performed to determine the 
      localization of LINC01133 and LINC01133 was observed mainly distributed in the 
      nucleus. Importantly, RNA pull-down and RIP assays showed that LINC01133 directly 
      combined with YBX1, and YBX1 can partly reverse the repression of NPC cell 
      proliferation, migration, and invasion caused by LINC01133. Collectively, our 
      exploration indicate that LINC01133 inhibits the malignant-biological behavior of 
      NPC cells by binding to YBX1, thereby suggesting a novel biomarker for the NPC 
      prognosis and treatment.
FAU - Zhang, Wenjun
AU  - Zhang W
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Du, Mingyu
AU  - Du M
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Wang, Tingting
AU  - Wang T
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Chen, Wei
AU  - Chen W
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Wu, Jing
AU  - Wu J
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Li, Qian
AU  - Li Q
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Tian, Xiaokang
AU  - Tian X
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
AD  - Xuzhou Medical University 209 Tong-Shan Road, Xuzhou, Jiangsu, China.
FAU - Qian, Luxi
AU  - Qian L
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Peng, Fanyu
AU  - Peng F
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Fei, Qian
AU  - Fei Q
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Chen, Jie
AU  - Chen J
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
AD  - Xuzhou Medical University 209 Tong-Shan Road, Xuzhou, Jiangsu, China.
FAU - He, Xia
AU  - He X
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
FAU - Yin, Li
AU  - Yin L
AD  - The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer 
      Hospital, Jiangsu Institute of Cancer Research 42 Bai Zi Ting Road, Nanjing, 
      Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20190401
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC6511644
OTO - NOTNLM
OT  - EMT
OT  - LINC01133
OT  - YBX1
OT  - nasopharyngeal carcinoma
COIS- None.
EDAT- 2019/05/21 06:00
MHDA- 2019/05/21 06:01
PMCR- 2019/04/01
CRDT- 2019/05/21 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2019/03/07 00:00 [accepted]
PHST- 2019/05/21 06:00 [entrez]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2019/05/21 06:01 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2019 Apr 1;9(4):779-790. eCollection 2019.