PMID- 31106289
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2474-7882 (Electronic)
IS  - 2474-7882 (Linking)
VI  - 2
IP  - 4
DP  - 2018 Dec
TI  - Obesity in relation to serum persistent organic pollutant concentrations in 
      CHAMACOS women.
PG  - e032
LID - e032 [pii]
LID - 10.1097/EE9.0000000000000032 [doi]
AB  - BACKGROUND: Environmental exposure to endocrine-disrupting chemicals (EDCs), 
      including persistent organic pollutants (POPs), has been hypothesized to increase 
      risk of obesity. Using data from the Center for Health Assessment of Mothers and 
      Children of Salinas (CHAMACOS) study, we examined the longitudinal relationship 
      between serum concentrations of a POPs mixture and several obesity measures. 
      METHODS: Concentrations of 17 POPs were measured in serum collected in 2009-2011 
      from 468 CHAMACOS women. Anthropometry measurements and personal interviews were 
      completed at up to three study visits between 2009 and 2014. We assessed the 
      relationship of serum POPs concentrations with adiposity measures longitudinally 
      using generalized estimating equation (GEE) models. We implemented Bayesian 
      Kernel Machine Regression (BKMR) to elucidate the effects of joint exposure to 
      the POPs mixture. RESULTS: In GEE models, positive associations with BMI were 
      found for dichlorodiphenyltrichloroethane (Q4 vs Q1: adjusted-beta = 3.2 kg/m(2); 
      95%CI 1.5,4.9), beta-hexachlorocyclohexane (Q4 vs Q1: adjusted-beta = 3.6 kg/m(2); 
      95%CI 2.0,5.2), and PBDE-47 (Q4 vs Q1: adjusted-beta = 1.9 kg/m(2); 95%CI 0.3,3.5), 
      while PBDE-153 was inversely associated (Q4 vs Q1: adjusted-beta = -2.8 kg/m(2); 
      95%CI -4.4,-1.2). BKMR results, while largely consistent with single pollutant 
      models, revealed the shape and direction of the exposure-response relationships, 
      as well as interactions among pollutants within the mixture, that could not be 
      discovered by single-pollutant models. CONCLUSION: In summary, we found 
      significant associations of serum POPs with several adiposity measures using both 
      conventional regressions and BKMR. Our results provide support for the chemical 
      obesogen hypothesis, that exposure to EDCs may alter risk for later obesity.
FAU - Warner, Marcella
AU  - Warner M
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California, Berkeley, California, USA.
FAU - Rauch, Stephen
AU  - Rauch S
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California, Berkeley, California, USA.
FAU - Coker, Eric S
AU  - Coker ES
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California, Berkeley, California, USA.
FAU - Harley, Kim
AU  - Harley K
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California, Berkeley, California, USA.
FAU - Kogut, Katherine
AU  - Kogut K
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California, Berkeley, California, USA.
FAU - Sjodin, Andreas
AU  - Sjodin A
AD  - Division of Laboratory Sciences, National Center for Environmental Health, 
      Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
FAU - Eskenazi, Brenda
AU  - Eskenazi B
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California, Berkeley, California, USA.
LA  - eng
GR  - R24 ES028529/ES/NIEHS NIH HHS/United States
GR  - P30 ES012072/ES/NIEHS NIH HHS/United States
GR  - R01 ES020360/ES/NIEHS NIH HHS/United States
GR  - R01 ES017054/ES/NIEHS NIH HHS/United States
GR  - R01 ES014565/ES/NIEHS NIH HHS/United States
GR  - P01 ES009605/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Environ Epidemiol
JT  - Environmental epidemiology (Philadelphia, Pa.)
JID - 101719527
PMC - PMC6521959
MID - NIHMS1509136
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2019/05/21 06:00
MHDA- 2019/05/21 06:01
PMCR- 2020/11/12
CRDT- 2019/05/21 06:00
PHST- 2019/05/21 06:00 [entrez]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2019/05/21 06:01 [medline]
PHST- 2020/11/12 00:00 [pmc-release]
AID - e032 [pii]
AID - 10.1097/EE9.0000000000000032 [doi]
PST - ppublish
SO  - Environ Epidemiol. 2018 Dec;2(4):e032. doi: 10.1097/EE9.0000000000000032.