PMID- 31107231
OWN - NLM
STAT- MEDLINE
DCOM- 20200107
LR  - 20240229
IS  - 1080-6059 (Electronic)
IS  - 1080-6040 (Print)
IS  - 1080-6040 (Linking)
VI  - 25
IP  - 6
DP  - 2019 Jun
TI  - Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect 
      Nonhuman Primates Against Lethal Nipah Virus Disease.
PG  - 1144-1152
LID - 10.3201/eid2506.181620 [doi]
AB  - Nipah virus (NiV) is a zoonotic pathogen that causes high case-fatality rates 
      (CFRs) in humans. Two NiV strains have caused outbreaks: the Malaysia strain 
      (NiV(M)), discovered in 1998-1999 in Malaysia and Singapore ( approximately 40% CFR); and the 
      Bangladesh strain (NiV(B)), discovered in Bangladesh and India in 2001 ( approximately 80% 
      CFR). Recently, NiV(B) in African green monkeys resulted in a more severe and 
      lethal disease than NiV(M). No NiV vaccines or treatments are licensed for human 
      use. We assessed replication-restricted single-injection recombinant vesicular 
      stomatitis vaccine NiV vaccine vectors expressing the NiV glycoproteins against 
      NiV(B) challenge in African green monkeys. All vaccinated animals survived to the 
      study endpoint without signs of NiV disease; all showed development of NiV F Ig, 
      NiV G IgG, or both, as well as neutralizing antibody titers. These data show 
      protective efficacy against a stringent and relevant NiV(B) model of human 
      infection.
FAU - Mire, Chad E
AU  - Mire CE
FAU - Geisbert, Joan B
AU  - Geisbert JB
FAU - Agans, Krystle N
AU  - Agans KN
FAU - Versteeg, Krista M
AU  - Versteeg KM
FAU - Deer, Daniel J
AU  - Deer DJ
FAU - Satterfield, Benjamin A
AU  - Satterfield BA
FAU - Fenton, Karla A
AU  - Fenton KA
FAU - Geisbert, Thomas W
AU  - Geisbert TW
LA  - eng
GR  - U01 AI082121/AI/NIAID NIH HHS/United States
GR  - UC7 AI094660/AI/NIAID NIH HHS/United States
PT  - Clinical Trial, Veterinary
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Emerg Infect Dis
JT  - Emerging infectious diseases
JID - 9508155
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - *Chlorocebus aethiops
MH  - *Henipavirus Infections/mortality/prevention & control/veterinary/virology
MH  - Immunity, Humoral
MH  - Monkey Diseases/pathology/virology
MH  - *Nipah Virus
MH  - *Vesiculovirus/immunology
MH  - Viral Load
MH  - *Viral Vaccines/immunology
MH  - *Zoonoses
PMC - PMC6537706
OTO - NOTNLM
OT  - Henipavirus
OT  - Nipah virus
OT  - nonhuman primates
OT  - vaccines
OT  - vesicular stomatitis virus
OT  - viruses
OT  - zoonoses
EDAT- 2019/05/21 06:00
MHDA- 2020/01/07 06:00
PMCR- 2019/06/01
CRDT- 2019/05/21 06:00
PHST- 2019/05/21 06:00 [entrez]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 18-1620 [pii]
AID - 10.3201/eid2506.181620 [doi]
PST - ppublish
SO  - Emerg Infect Dis. 2019 Jun;25(6):1144-1152. doi: 10.3201/eid2506.181620.