PMID- 31107560
OWN - NLM
STAT- MEDLINE
DCOM- 20200114
LR  - 20200114
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 60
IP  - 4
DP  - 2019 Oct
TI  - Assessing the modulation of cutaneous sensory fiber excitability using a fast 
      perception threshold tracking technique.
PG  - 367-375
LID - 10.1002/mus.26520 [doi]
AB  - INTRODUCTION: Topical application of lidocaine-and-prilocaine (LP) cream 
      attenuates the functionality of small cutaneous nerve fibers. The aim of this 
      human study was to measure the underlying excitability modulation of small 
      cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) 
      technique. METHODS: Small sensory fibers were selectively blocked by 120-minute 
      topical application of LP and confirmed by quantitative sensory testing. 
      Excitability changes of small (activated by a specially designed pin electrode) 
      and large (patch electrode) nerve fibers were assessed as the strength-duration 
      relation and threshold electrotonus. RESULTS: The excitability assessed by the 
      strength-duration relation and threshold electrotonus was significantly modulated 
      for the small afferents (P < 0.05, Wilcoxon's test) but not the large afferents. 
      DISCUSSION: This novel PTT technique was able to assess inhibition of membrane 
      properties of small cutaneous fibers, suggesting the usefulness of the technique 
      as a diagnostic method for assessing impairment of small fibers, as seen in many 
      types of polyneuropathies.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Nielson Hoberg, Tatiana
AU  - Nielson Hoberg T
AD  - Department of Health Science and Technology, Center for Sensory-Motor Interaction 
      (SMI), Aalborg University, Fredrik Bajers Vej 7 D3, 9220 Aalborg O, Denmark.
FAU - Frahm, Steffen
AU  - Frahm S
AD  - Center for Neuroplasticity and Pain, SMI, Department of Health Science and 
      Technology, Aalborg University, Aalborg, Denmark.
FAU - Hennings, Kristian
AU  - Hennings K
AD  - Department of Health Science and Technology, Center for Sensory-Motor Interaction 
      (SMI), Aalborg University, Fredrik Bajers Vej 7 D3, 9220 Aalborg O, Denmark.
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
AD  - Department of Health Science and Technology, Center for Sensory-Motor Interaction 
      (SMI), Aalborg University, Fredrik Bajers Vej 7 D3, 9220 Aalborg O, Denmark.
AD  - Center for Neuroplasticity and Pain, SMI, Department of Health Science and 
      Technology, Aalborg University, Aalborg, Denmark.
FAU - Dahl Morch, Carsten
AU  - Dahl Morch C
AUID- ORCID: 0000-0001-6693-2028
AD  - Department of Health Science and Technology, Center for Sensory-Motor Interaction 
      (SMI), Aalborg University, Fredrik Bajers Vej 7 D3, 9220 Aalborg O, Denmark.
AD  - Center for Neuroplasticity and Pain, SMI, Department of Health Science and 
      Technology, Aalborg University, Aalborg, Denmark.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20190605
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Anesthetics, Local)
RN  - 0 (Lidocaine, Prilocaine Drug Combination)
SB  - IM
CIN - Muscle Nerve. 2019 Oct;60(4):345-346. PMID: 31348532
MH  - Administration, Cutaneous
MH  - Adult
MH  - Anesthetics, Local/*pharmacology
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Electric Stimulation
MH  - Electrodiagnosis
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Lidocaine, Prilocaine Drug Combination/*pharmacology
MH  - Male
MH  - Nerve Fibers, Myelinated/*drug effects/physiology
MH  - Nerve Fibers, Unmyelinated/drug effects/physiology
MH  - Sensory Thresholds/*drug effects/physiology
MH  - Small Fiber Neuropathy/*diagnosis
MH  - Young Adult
OTO - NOTNLM
OT  - cutaneous analgesia
OT  - nerve fiber excitability
OT  - perception thresholds
OT  - pin electrode
OT  - quantitative sensory testing
OT  - small fiber neuropathy
OT  - threshold tracking
EDAT- 2019/05/21 06:00
MHDA- 2020/01/15 06:00
CRDT- 2019/05/21 06:00
PHST- 2018/10/17 00:00 [received]
PHST- 2019/05/14 00:00 [revised]
PHST- 2019/05/14 00:00 [accepted]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2020/01/15 06:00 [medline]
PHST- 2019/05/21 06:00 [entrez]
AID - 10.1002/mus.26520 [doi]
PST - ppublish
SO  - Muscle Nerve. 2019 Oct;60(4):367-375. doi: 10.1002/mus.26520. Epub 2019 Jun 5.