PMID- 31108178
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20200330
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 94
DP  - 2019 Aug 30
TI  - Histamine H(3) receptor activation reduces the impairment in prepulse inhibition 
      (PPI) of the acoustic startle response and Akt phosphorylation induced by MK-801 
      (dizocilpine), antagonist at N-Methyl-d-Aspartate (NMDA) receptors.
PG  - 109653
LID - S0278-5846(18)30982-5 [pii]
LID - 10.1016/j.pnpbp.2019.109653 [doi]
AB  - We have investigated the effect of the local activation of histamine H(3) 
      receptors (H(3)Rs) in the rat prefrontal cortex (PFCx) on the impairment of 
      pre-pulse inhibition (PPI) of the startle response induced by the systemic 
      administration of MK-801, antagonist at glutamate N-Methyl-d-Aspartate (NMDA) 
      receptors, and the possible functional interaction between H(3)Rs and MK-801 on 
      PFCx dopaminergic transmission. Infusion of the H(3)R agonist RAMH (19.8 ng/1 mul) 
      into the PFCx reduced or prevented the inhibition by MK-801 (0.15 mg/kg, ip) of 
      PPI evoked by different auditory stimulus intensities (5, 10 and 15 dB), and the 
      RAMH effect was blocked by the H(3)R antagonist/inverse agonist ciproxifan 
      (30.6 ng/1 mul). MK-801 inhibited [(3)H]-dopamine uptake (-45.4 +/- 2.1%) and 
      release (-32.8 +/- 2.6%) in PFCx synaptosomes or slices, respectively, and 
      molecular modeling indicated that MK-801 binds to and blocks the rat and human 
      dopamine transporters. However, H(3)R activation had no effect on the inhibitory 
      action of MK-801 on dopamine uptake and release. In PFCx slices, MK-801 and the 
      activation of H(3)Rs or dopamine D(1) receptors (D(1)Rs) stimulated ERK-1/2 and 
      Akt phosphorylation. The co-activation of D(1)Rs and H(3)Rs prevented ERK-1/2 and 
      Akt phosphorylation, and H(3)R activation or D(1)R blockade prevented the effect 
      of MK-801. In ex vivo experiments, the intracortical infusion of the D(1)R 
      agonist SKF-81297 (37 ng/1 mul) or the H(3)R agonist RAMH increased Akt 
      phosphorylation, prevented by D(1)R/H(3)R co-activation. These results indicate 
      that MK-801 enhances dopaminergic transmission in the PFCx, and that H(3)R 
      activation counteracts the post-synaptic actions of dopamine.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Aquino-Miranda, Guillermo
AU  - Aquino-Miranda G
AD  - Doctorado en Ciencias Biologicas y de la Salud, Universidad Autonoma 
      Metropolitana Unidad Xochimilco, Ciudad de Mexico, Mexico; Departamento de 
      Fisiologia, Biofisica y Neurociencias, Centro de Investigacion y de Estudios 
      Avanzados (Cinvestav) del IPN, Av. IPN 2508, 07360 Ciudad de Mexico, Mexico.
FAU - Rivera-Ramirez, Nayeli
AU  - Rivera-Ramirez N
AD  - Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigacion y 
      de Estudios Avanzados (Cinvestav) del IPN, Av. IPN 2508, 07360 Ciudad de Mexico, 
      Mexico.
FAU - Marquez-Gomez, Ricardo
AU  - Marquez-Gomez R
AD  - Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigacion y 
      de Estudios Avanzados (Cinvestav) del IPN, Av. IPN 2508, 07360 Ciudad de Mexico, 
      Mexico.
FAU - Escamilla-Sanchez, Juan
AU  - Escamilla-Sanchez J
AD  - Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigacion y 
      de Estudios Avanzados (Cinvestav) del IPN, Av. IPN 2508, 07360 Ciudad de Mexico, 
      Mexico.
FAU - Gonzalez-Pantoja, Raul
AU  - Gonzalez-Pantoja R
AD  - Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigacion y 
      de Estudios Avanzados (Cinvestav) del IPN, Av. IPN 2508, 07360 Ciudad de Mexico, 
      Mexico.
FAU - Ramos-Languren, Laura-Elisa
AU  - Ramos-Languren LE
AD  - Coordinacion de Psicobiologia y Neurociencias, Facultad de Psicologia, UNAM, Av. 
      Universidad 3004, 04510 Ciudad de Mexico, Mexico.
FAU - Perez-Neri, Ivan
AU  - Perez-Neri I
AD  - Departamento de Neuroquimica, Instituto Nacional de Neurologia y Neurocirugia 
      SSa, Av. Insurgentes Sur 3877, 14269 Ciudad de Mexico, Mexico.
FAU - Bueno-Nava, Antonio
AU  - Bueno-Nava A
AD  - Division de Neurociencias, Instituto Nacional de Rehabilitacion, SSa, Calzada 
      Mexico-Xochimilco 289, 14389 Ciudad de Mexico, Mexico.
FAU - Rios, Camilo
AU  - Rios C
AD  - Departamento de Neuroquimica, Instituto Nacional de Neurologia y Neurocirugia 
      SSa, Av. Insurgentes Sur 3877, 14269 Ciudad de Mexico, Mexico; Laboratorio de 
      Neurofarmacologia Molecular, Departamento de Sistemas Biologicos, Universidad 
      Autonoma Metropolitana, Unidad Xochimilco, Calzada del Hueso 1100, 04960 Ciudad 
      de Mexico, Mexico.
FAU - Arias-Montano, Jose-Antonio
AU  - Arias-Montano JA
AD  - Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigacion y 
      de Estudios Avanzados (Cinvestav) del IPN, Av. IPN 2508, 07360 Ciudad de Mexico, 
      Mexico. Electronic address: jaarias@fisio.cinvestav.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190517
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Benzazepines)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Histamine Agonists)
RN  - 0 (Imidazoles)
RN  - 0 (Receptors, Histamine H3)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 10028-17-8 (Tritium)
RN  - 5EVQ7IRG99 (ciproxifan)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 71636-61-8 (SK&F 81297)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Benzazepines/administration & dosage/pharmacology
MH  - Dizocilpine Maleate/administration & dosage/*pharmacology
MH  - Dopamine/metabolism
MH  - Dopamine Plasma Membrane Transport Proteins/metabolism
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Histamine Agonists/administration & dosage/pharmacology
MH  - Imidazoles/administration & dosage/pharmacology
MH  - Male
MH  - Microinjections
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Molecular Docking Simulation
MH  - Phosphorylation/drug effects
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Prepulse Inhibition/*drug effects
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Rats
MH  - Receptors, Histamine H3/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors/metabolism
MH  - Reflex, Startle/*drug effects
MH  - Tritium/metabolism
OTO - NOTNLM
OT  - Dopamine
OT  - Histamine
OT  - Histamine H(3) receptor
OT  - MK-801
OT  - Prefrontal cortex
OT  - Schizophrenia
EDAT- 2019/05/21 06:00
MHDA- 2020/03/31 06:00
CRDT- 2019/05/21 06:00
PHST- 2018/12/19 00:00 [received]
PHST- 2019/05/14 00:00 [revised]
PHST- 2019/05/15 00:00 [accepted]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2019/05/21 06:00 [entrez]
AID - S0278-5846(18)30982-5 [pii]
AID - 10.1016/j.pnpbp.2019.109653 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109653. doi: 
      10.1016/j.pnpbp.2019.109653. Epub 2019 May 17.