PMID- 31108257
OWN - NLM
STAT- MEDLINE
DCOM- 20200811
LR  - 20200811
IS  - 1878-7568 (Electronic)
IS  - 1742-7061 (Linking)
VI  - 94
DP  - 2019 Aug
TI  - Role of dendritic cells in the host response to biomaterials and their signaling 
      pathways.
PG  - 132-144
LID - S1742-7061(19)30365-4 [pii]
LID - 10.1016/j.actbio.2019.05.038 [doi]
AB  - Strategies to enhance, inhibit, or qualitatively modulate immune responses are 
      important for diverse biomedical applications such as vaccine adjuvant, drug 
      delivery, immunotherapy, cell transplant, tissue engineering, and regenerative 
      medicine. However, the clinical efficiency of these biomaterial systems is 
      affected by the limited understanding of their interaction with complex host 
      microenvironments, for example, excessive foreign body reaction and 
      immunotoxicity. Biomaterials and biomedical devices implanted in the body may 
      induce a highly complicated and orchestrated series of host responses. As 
      macrophages are among the first cells to infiltrate and respond to implanted 
      biomaterials, the macrophage-mediated host response to biomaterials has been well 
      studied. Dendritic cells (DCs) are the most potent antigen-presenting cells that 
      activate naive T cells and bridge innate and adaptive immunity. The potential 
      interaction of DCs with biomaterials appears to be critical for exerting the 
      function of biomaterials and has become an important, developing area of 
      investigation. Herein, we summarize the effects of the physicochemical properties 
      of biomaterials on the immune function of DCs together with their receptors and 
      signaling pathways. This review might provide a complete understanding of the 
      interaction of DCs with biomaterials and serve as a reference for the design and 
      selection of biomaterials with particular effects on targeted cells. STATEMENT OF 
      SIGNIFICANCE: Biomaterials implanted in the body are increasingly applied in 
      clinical practice. The performance of these implanted biomaterials is largely 
      dependent on their interaction with the host immune system. As antigen-presenting 
      cells, dendritic cells (DCs) directly interact with biomaterials through pattern 
      recognition receptors (PRRs) recognizing "biomaterial-associated molecular 
      patterns" and generate a battery of immune responses. In this review, the 
      physicochemical properties of biomaterials that regulate the immune function of 
      DCs together with their receptors and signaling pathways of biomaterial-DC 
      interactions are summarized and discussed. We believe that knowledge of the 
      interplay of DC and biomaterials may spur clinical translation by guiding the 
      design and selection of biomaterials with particular effects on targeted cell for 
      tissue engineering, vaccine delivery, and cancer therapy.
CI  - Copyright (c) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Zhu, Fu-Jun
AU  - Zhu FJ
AD  - Trauma Research Center, Fourth Medical Center of the Chinese PLA General 
      Hospital, Beijing 100048, People's Republic of China; Department of Burns, 
      Plastic and Wound Repair Surgery, The No. 924th Hospital of the Joint Logistic 
      Support Force of the Chinese PLA, Guilin 541002, People's Republic of China.
FAU - Tong, Ya-Lin
AU  - Tong YL
AD  - Department of Burns, Plastic and Wound Repair Surgery, The No. 924th Hospital of 
      the Joint Logistic Support Force of the Chinese PLA, Guilin 541002, People's 
      Republic of China.
FAU - Sheng, Zhi-Yong
AU  - Sheng ZY
AD  - Trauma Research Center, Fourth Medical Center of the Chinese PLA General 
      Hospital, Beijing 100048, People's Republic of China. Electronic address: 
      shengzhy@cae.cn.
FAU - Yao, Yong-Ming
AU  - Yao YM
AD  - Trauma Research Center, Fourth Medical Center of the Chinese PLA General 
      Hospital, Beijing 100048, People's Republic of China. Electronic address: 
      c_ff@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190517
PL  - England
TA  - Acta Biomater
JT  - Acta biomaterialia
JID - 101233144
RN  - 0 (Biocompatible Materials)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Biocompatible Materials/*chemistry
MH  - Bone Marrow Cells/cytology
MH  - Cell Transplantation
MH  - Dendritic Cells/*cytology
MH  - Foreign-Body Reaction/metabolism
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Macrophages/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Phenotype
MH  - Regenerative Medicine
MH  - *Signal Transduction
MH  - Surface Properties
MH  - Tissue Engineering
OTO - NOTNLM
OT  - Biomaterials
OT  - Dendritic cells
OT  - Immune function
OT  - Receptors
OT  - Signaling pathway
EDAT- 2019/05/21 06:00
MHDA- 2020/08/12 06:00
CRDT- 2019/05/21 06:00
PHST- 2019/01/09 00:00 [received]
PHST- 2019/05/09 00:00 [revised]
PHST- 2019/05/15 00:00 [accepted]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2020/08/12 06:00 [medline]
PHST- 2019/05/21 06:00 [entrez]
AID - S1742-7061(19)30365-4 [pii]
AID - 10.1016/j.actbio.2019.05.038 [doi]
PST - ppublish
SO  - Acta Biomater. 2019 Aug;94:132-144. doi: 10.1016/j.actbio.2019.05.038. Epub 2019 
      May 17.