PMID- 31108379
OWN - NLM
STAT- MEDLINE
DCOM- 20200331
LR  - 20200331
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 253
DP  - 2019 Jun 15
TI  - Efficacy of cognitive behavioural therapy with medication for patients with 
      obsessive-compulsive disorder: A multicentre randomised controlled trial in 
      China.
PG  - 184-192
LID - S0165-0327(18)33272-5 [pii]
LID - 10.1016/j.jad.2019.04.090 [doi]
AB  - BACKGROUND: Meta-analyses support the efficacy of cognitive behavioural therapy 
      (CBT) for obsessive-compulsive disorder (OCD) in Western cultures. However, there 
      are no adequately powered multicentre studies in China. This study aimed to 
      compare the effectiveness of treatment with CBT combined with medication and 
      medication alone in OCD patients in China. METHODS: OCD patients (N = 167) were 
      recruited from outpatient clinics at three large tertiary psychiatric hospitals 
      and one general hospital in China. Participants were randomly allocated to 
      receive either CBT combined with medication (n = 92) or medication alone (n = 75) 
      for a 24-week treatment period. Participants' symptoms and social functioning 
      were assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Hamilton 
      Anxiety Rating Scale (HAM-A), Global Assessment of Functioning (GAF) and Clinical 
      Global Impression Scale for Severity (CGI-S) at 0, 4, 8, 12 and 24 weeks, and the 
      effectiveness of the two treatments compared using linear mixed-effects models. 
      RESULTS: At 24 weeks, both groups showed large within-group effects in all 
      measures. Significantly more patients receiving combined therapy than medication 
      alone had a decrease in symptom severity of at least 35% (based on Y-BOCS total 
      score). The CGI-S and GAF scores decreased in both groups, and significant 
      differences were found between the groups. LIMITATIONS: Study limitations 
      included lack of consideration of medication types and dosages, and the absence 
      of a CBT-only arm. CONCLUSIONS: CBT combined with medication may be effective in 
      alleviating symptoms and social functioning impairment associated with OCD, and 
      is more effective than medication alone in China, particularly for the treatment 
      of compulsive behaviours.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Meng, Fan-Qiang
AU  - Meng FQ
AD  - The Department of Clinical Psychology & National Clinical Research Center for 
      Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding 
      Hospital, Capital Medical University, and Center of Schizophrenia, Beijing 
      Institute for Brain Disorders, No. 5 Ankang Hutong Deshengmen, WaiXicheng 
      District, 100088 Beijing, People's Republic of China; Advanced Innovation Center 
      for Human Brain Protection, Capital Medical University, No. 5 Ankang Hutong 
      Deshengmen, WaiXicheng District, 100088 Beijing, People's Republic of China.
FAU - Han, Hai-Ying
AU  - Han HY
AD  - The Department of Clinical Psychology & National Clinical Research Center for 
      Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding 
      Hospital, Capital Medical University, and Center of Schizophrenia, Beijing 
      Institute for Brain Disorders, No. 5 Ankang Hutong Deshengmen, WaiXicheng 
      District, 100088 Beijing, People's Republic of China; Advanced Innovation Center 
      for Human Brain Protection, Capital Medical University, No. 5 Ankang Hutong 
      Deshengmen, WaiXicheng District, 100088 Beijing, People's Republic of China.
FAU - Luo, Jia
AU  - Luo J
AD  - The Department of Clinical Psychology & National Clinical Research Center for 
      Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding 
      Hospital, Capital Medical University, and Center of Schizophrenia, Beijing 
      Institute for Brain Disorders, No. 5 Ankang Hutong Deshengmen, WaiXicheng 
      District, 100088 Beijing, People's Republic of China; Advanced Innovation Center 
      for Human Brain Protection, Capital Medical University, No. 5 Ankang Hutong 
      Deshengmen, WaiXicheng District, 100088 Beijing, People's Republic of China.
FAU - Liu, Jing
AU  - Liu J
AD  - The Department of Clinical Psychology & National Clinical Research Center for 
      Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding 
      Hospital, Capital Medical University, and Center of Schizophrenia, Beijing 
      Institute for Brain Disorders, No. 5 Ankang Hutong Deshengmen, WaiXicheng 
      District, 100088 Beijing, People's Republic of China; Advanced Innovation Center 
      for Human Brain Protection, Capital Medical University, No. 5 Ankang Hutong 
      Deshengmen, WaiXicheng District, 100088 Beijing, People's Republic of China.
FAU - Liu, Zhao-Rui
AU  - Liu ZR
AD  - Peking University Sixth Hospital (Institute of Mental Health), National Clinical 
      Research Center for Mental Disorders and Key Laboratory of Mental Health, 
      Ministry of Health (Peking University), Beijing 100191, People's Republic of 
      China.
FAU - Tang, Yi
AU  - Tang Y
AD  - Peking University Sixth Hospital (Institute of Mental Health), National Clinical 
      Research Center for Mental Disorders and Key Laboratory of Mental Health, 
      Ministry of Health (Peking University), Beijing 100191, People's Republic of 
      China.
FAU - Hou, Xuan
AU  - Hou X
AD  - Peking University Sixth Hospital (Institute of Mental Health), National Clinical 
      Research Center for Mental Disorders and Key Laboratory of Mental Health, 
      Ministry of Health (Peking University), Beijing 100191, People's Republic of 
      China.
FAU - Wei, Jing
AU  - Wei J
AD  - Department of Psychological Medicine, Peking Union Medical College Hospital, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 
      100730, People's Republic of China.
FAU - Shi, Li-Li
AU  - Shi LL
AD  - Department of Psychological Medicine, Peking Union Medical College Hospital, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 
      100730, People's Republic of China.
FAU - Tang, Mou-Ni
AU  - Tang MN
AD  - Department of Pediatrics, The Affiliated Brain Hospital of Guangzhou Medical 
      University (Guangzhou Huiai Hospital), Guangzhou 510370, People's Republic of 
      China.
FAU - Yan, Yong-Ping
AU  - Yan YP
AD  - Department of Epidemiology, Faculty of Preventive Medicine, The Fourth Military 
      Medical University, Xi'an, People's Republic of China.
FAU - Huang, Yue-Qin
AU  - Huang YQ
AD  - Peking University Sixth Hospital (Institute of Mental Health), National Clinical 
      Research Center for Mental Disorders and Key Laboratory of Mental Health, 
      Ministry of Health (Peking University), Beijing 100191, People's Republic of 
      China. Electronic address: huangyq@bjmu.edu.cn.
FAU - Sun, Jing
AU  - Sun J
AD  - School of Medicine, Griffith University, Queensland, Q4222 Australia. Electronic 
      address: j.sun@griffith.edu.au.
FAU - Li, Zhan-Jiang
AU  - Li ZJ
AD  - The Department of Clinical Psychology & National Clinical Research Center for 
      Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding 
      Hospital, Capital Medical University, and Center of Schizophrenia, Beijing 
      Institute for Brain Disorders, No. 5 Ankang Hutong Deshengmen, WaiXicheng 
      District, 100088 Beijing, People's Republic of China; Advanced Innovation Center 
      for Human Brain Protection, Capital Medical University, No. 5 Ankang Hutong 
      Deshengmen, WaiXicheng District, 100088 Beijing, People's Republic of China. 
      Electronic address: lizhj8@ccmu.edu.cn.
LA  - eng
SI  - ChiCTR/ChiCTR-TRC-10001123
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20190422
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - China
MH  - Cognitive Behavioral Therapy/*methods
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obsessive-Compulsive Disorder/psychology/*therapy
MH  - Severity of Illness Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Clinical Global Impression Scale for Severity
OT  - Cognitive behaviour therapy
OT  - Global assessment of functioning
OT  - Hamilton Anxiety Rating Scale
OT  - Obsessive compulsive disorders
OT  - Yale-Brown Obsessive-Compulsive Scale
EDAT- 2019/05/21 06:00
MHDA- 2020/04/01 06:00
CRDT- 2019/05/21 06:00
PHST- 2019/01/02 00:00 [received]
PHST- 2019/04/11 00:00 [revised]
PHST- 2019/04/21 00:00 [accepted]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2020/04/01 06:00 [medline]
PHST- 2019/05/21 06:00 [entrez]
AID - S0165-0327(18)33272-5 [pii]
AID - 10.1016/j.jad.2019.04.090 [doi]
PST - ppublish
SO  - J Affect Disord. 2019 Jun 15;253:184-192. doi: 10.1016/j.jad.2019.04.090. Epub 
      2019 Apr 22.