PMID- 31108393
OWN - NLM
STAT- MEDLINE
DCOM- 20191107
LR  - 20191107
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 129
DP  - 2019 Aug
TI  - Selected persistent organic pollutants associated with the risk of primary 
      ovarian insufficiency in women.
PG  - 51-58
LID - S0160-4120(19)30038-8 [pii]
LID - 10.1016/j.envint.2019.05.023 [doi]
AB  - Although some persistent organic pollutants (POPs) may not be currently in 
      production, many of these chemicals still exist ubiquitously in the environment 
      and continue to represent significant environmental health concern. One of the 
      important concerns of POPs exposure may lead to the adverse reproductive 
      consequences including primary ovarian insufficiency (POI), but the limited 
      evidence has been reported so far. Our case-control study was performed to 
      explore the association between serum levels of selected POPs and risk for POI in 
      a Chinese female population, including 157 cases and 217 healthy controls. Serum 
      concentrations of polychlorinated biphenyls (PCBs), organochlorine pesticides 
      (OCPs), polybrominated diphenyl ethers (PBDEs) and serum levels of reproductive 
      hormones [follicle-stimulating hormone (FSH), luteinizing hormone (LH), 
      anti-Mullerian hormone (AMH) and estradiol] were measured. The medians of 
      dioxin-like PCBs (DL-PCBs) and p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) 
      were significantly higher in case sera than in controls. Higher concentrations of 
      DL-PCBs and p,p'-DDT were significantly associated with elevated risk of POI. A 
      dose-response relationship was observed between the sum of DL-PCBs (Sigma(6) DL-PCBs) 
      and the risk of POI (p for trend = 0.003), with odds ratios for the second and 
      third tertiles, compared with the first, of 1.31- (95% CIs: 0.67-2.57) and 
      3.15-fold (95% CIs: 1.63-6.10), respectively. Similar results were observed for 
      the sum of p,p'-DDT and its metabolites (Sigma(2) p,p'-DDTs). In control women, FSH 
      levels were negatively associated with PCBs exposure, while LH had a positive 
      association with OCPs. In patients with POI, exposure to PCBs was correlated with 
      higher levels of LH, whereas exposure to OCPs was associated with lower levels of 
      AMH. To the best of our knowledge, this study for the first provided evidence 
      that exposure to PCBs and DDT could be the potential risk factors for POI in 
      women.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Pan, Wuye
AU  - Pan W
AD  - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of 
      Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
FAU - Ye, Xiaoqing
AU  - Ye X
AD  - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of 
      Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; 
      College of Medical Technology, Zhejiang Chinese Medical University, Hangzhou 
      310053, China.
FAU - Yin, Shanshan
AU  - Yin S
AD  - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of 
      Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
FAU - Ma, Xiaochen
AU  - Ma X
AD  - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of 
      Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
FAU - Li, Chunming
AU  - Li C
AD  - Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's 
      Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
FAU - Zhou, Jianhong
AU  - Zhou J
AD  - Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's 
      Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China. 
      Electronic address: zhoujh1117@zju.edu.cn.
FAU - Liu, Weiping
AU  - Liu W
AD  - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of 
      Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
FAU - Liu, Jing
AU  - Liu J
AD  - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of 
      Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. 
      Electronic address: jliue@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190517
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Gonadal Steroid Hormones/*blood
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Primary Ovarian Insufficiency/chemically induced/*epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - Organochlorine pesticides
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
OT  - Primary ovarian insufficiency
OT  - Reproductive health
OT  - Women
EDAT- 2019/05/21 06:00
MHDA- 2019/11/08 06:00
CRDT- 2019/05/21 06:00
PHST- 2019/01/04 00:00 [received]
PHST- 2019/05/09 00:00 [revised]
PHST- 2019/05/09 00:00 [accepted]
PHST- 2019/05/21 06:00 [pubmed]
PHST- 2019/11/08 06:00 [medline]
PHST- 2019/05/21 06:00 [entrez]
AID - S0160-4120(19)30038-8 [pii]
AID - 10.1016/j.envint.2019.05.023 [doi]
PST - ppublish
SO  - Environ Int. 2019 Aug;129:51-58. doi: 10.1016/j.envint.2019.05.023. Epub 2019 May 
      17.