PMID- 31108510 OWN - NLM STAT- MEDLINE DCOM- 20200205 LR - 20230214 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 109 IP - 6 DP - 2019 Jun 1 TI - Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans. PG - 1683-1695 LID - 10.1093/ajcn/nqz001 [doi] AB - BACKGROUND: Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behavior is a matter of debate. OBJECTIVE: We evaluated the impact of consuming ITF-rich vegetables daily on gut microbiota, gastro-intestinal symptoms, and food-related behavior in healthy individuals. METHODS: A single group-design trial was conducted in 26 healthy individuals. During 2 wk, the participants were instructed to adhere to a controlled diet based on ITF-rich vegetables (providing a mean intake of 15 g ITF/d). Three test days were organized: before and after the nutritional intervention and 3 wk after returning to their usual diet. We assessed nutrient intake, food-related behavior, fecal microbiota composition, microbial fermentation, and gastrointestinal symptoms. RESULTS: The major microbial modifications during the intervention were an increased proportion of the Bifidobacterium genus, a decreased level of unclassified Clostridiales, and a tendency to decrease Oxalobacteraceae. These changes were reversed 3 wk after the intervention. The volunteers showed greater satiety, a reduced desire to eat sweet, salty, and fatty food, and a trend to increase hedonic attitudes towards some inulin-rich vegetables. Only flatulence episodes were reported during the dietary intervention, whereas intestinal discomfort, inversely associated with Clostridium cluster IV and Ruminococcus callidus, was improved at the end of the intervention. CONCLUSIONS: A higher consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber, which may in turn improve food-related behavior. Moreover, it leads to beneficial modifications of the gut microbiota composition and function. This trial is registered at clinicaltrial.gov as NCT03540550. CI - Copyright (c) American Society for Nutrition 2019. FAU - Hiel, Sophie AU - Hiel S AD - Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Brussels, Belgium. FAU - Bindels, Laure B AU - Bindels LB AD - Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Brussels, Belgium. FAU - Pachikian, Barbara D AU - Pachikian BD AD - Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Brussels, Belgium. FAU - Kalala, Gaetan AU - Kalala G AD - Gembloux Agro-Bio Tech, Universite de Liege, Gembloux, Belgium. FAU - Broers, Valerie AU - Broers V AD - Research Institute for Psychological Sciences, Universite catholique de Louvain, Louvain-La-Neuve, Belgium. FAU - Zamariola, Giorgia AU - Zamariola G AD - Research Institute for Psychological Sciences, Universite catholique de Louvain, Louvain-La-Neuve, Belgium. FAU - Chang, Betty P I AU - Chang BPI AD - Faculty of Psychological Science, and Education, Universite libre de Bruxelles, Belgium. FAU - Kambashi, Bienvenu AU - Kambashi B AD - Gembloux Agro-Bio Tech, Universite de Liege, Gembloux, Belgium. FAU - Rodriguez, Julie AU - Rodriguez J AD - Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Brussels, Belgium. FAU - Cani, Patrice D AU - Cani PD AD - Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Brussels, Belgium. AD - WELBIO-Walloon Excellence in Life Sciences and BIOtechnology, Universite catholique de Louvain, Brussels, Belgium. FAU - Neyrinck, Audrey M AU - Neyrinck AM AD - Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Brussels, Belgium. FAU - Thissen, Jean-Paul AU - Thissen JP AD - Endocrinology, Diabetology, and Nutrition Department, Institut de Recherche Experimentale et Clinique IREC, Universite catholique de Louvain, Brussels, Belgium. FAU - Luminet, Olivier AU - Luminet O AD - Research Institute for Psychological Sciences, Universite catholique de Louvain, Louvain-La-Neuve, Belgium. FAU - Bindelle, Jerome AU - Bindelle J AD - Gembloux Agro-Bio Tech, Universite de Liege, Gembloux, Belgium. FAU - Delzenne, Nathalie M AU - Delzenne NM AD - Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Brussels, Belgium. LA - eng SI - ClinicalTrials.gov/NCT03540550 PT - Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Dietary Fiber) RN - 0 (Prebiotics) RN - 9005-80-5 (Inulin) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Bacteria/classification/genetics/isolation & purification MH - Diet MH - Dietary Fiber/analysis/metabolism MH - Feces/microbiology MH - *Feeding Behavior MH - Female MH - *Gastrointestinal Microbiome MH - Healthy Volunteers MH - Humans MH - Inulin/analysis/*metabolism MH - Male MH - Middle Aged MH - Prebiotics/analysis MH - Vegetables/chemistry/*metabolism MH - Young Adult PMC - PMC6537941 OTO - NOTNLM OT - gut health OT - gut microbiota OT - healthy humans OT - inulin-rich vegetables OT - microbial fermentation OT - nutrition OT - nutritional behavior EDAT- 2019/05/21 06:00 MHDA- 2020/02/06 06:00 PMCR- 2019/04/24 CRDT- 2019/05/21 06:00 PHST- 2018/06/18 00:00 [received] PHST- 2019/01/02 00:00 [accepted] PHST- 2019/05/21 06:00 [pubmed] PHST- 2020/02/06 06:00 [medline] PHST- 2019/05/21 06:00 [entrez] PHST- 2019/04/24 00:00 [pmc-release] AID - S0002-9165(22)03211-7 [pii] AID - nqz001 [pii] AID - 10.1093/ajcn/nqz001 [doi] PST - ppublish SO - Am J Clin Nutr. 2019 Jun 1;109(6):1683-1695. doi: 10.1093/ajcn/nqz001.