PMID- 31109008
OWN - NLM
STAT- MEDLINE
DCOM- 20200131
LR  - 20200309
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 9
IP  - 5
DP  - 2019 May 17
TI  - Clinical Value of Circulating Microribonucleic Acids miR-1 and miR-21 in 
      Evaluating the Diagnosis of Acute Heart Failure in Asymptomatic Type 2 Diabetic 
      Patients.
LID - 10.3390/biom9050193 [doi]
LID - 193
AB  - To investigate whether the circulating miR-1 (microRNA-1) and miR-21 expression 
      might be used in the diagnosis of heart failure (HF) and silent coronary artery 
      disease (SCAD) in asymptomatic type 2 diabetes mellitus (T2DM) patients and to 
      explore the relationship of these miRs with N-terminal pro-brain natriuretic 
      peptide (NT-proBNP) and galectin-3. One hundred thirty-five consecutive patients 
      with T2DM and 45 matched control subjects were enrolled in the study. This study 
      consisted of the following four groups: control group (mean age: 60.23 +/- 6.27 
      years, female/male (F/M): 23/22); diabetic group (DM) (mean age: 61.50 +/- 5.08, 
      F/M: 23/22); DM + SCAD group (mean age: 61.61 +/- 6.02, F/M: 20/25); and DM + acute 
      HF group (mean age: 62.07 +/- 5.26 years, F/M: 20/25). miR-1 was downregulated in 
      the DM, CAD + DM and HF + DM groups by 0.54, 0.54, and 0.12 fold as compared with 
      controls, respectively. The miR-1 levels were significantly lower in HF + DM than 
      DM with 0.22 fold changes (p < 0.001); and in patients with CAD + DM group with 
      0.22 fold changes (p < 0.001). Similarly, miR-21 was overexpressed in patients 
      with DM, CAD + DM, and HF + DM with 1.30, 1.79 and 2.21 fold changes as compared 
      with controls, respectively. An interesting finding is that the miR-21 expression 
      was significantly higher in the HF + DM group as compared with the CAD + DM 
      group; miR-1 was negatively correlated with NT-proBNP (r = -0.891, p < 0.001) and 
      galectin-3 (r = -0.886, p < 0.001) in the HF + DM group; and miR-21 showed a 
      strongly positive correlation with (r = 0.734, p < 0.001) and galectin-3 (r = 
      0.764. p < 0.001) in the HF + DM group. These results suggest that the 
      circulating decreased miR-1 and increased miR-21 expression are associated with 
      NT-proBNP and galectin-3 levels in acute HF + DM. Especially the miR-21 
      expression might be useful in predicting the onset of acute HF in asymptomatic 
      T2DM patients. The miR-21 expression is more valuable than the miR-1 expression 
      in predicting cardiovascular events of acute HF and the combined analysis of 
      miR-21 expression, galectin-3, and NT-proBNP can increase the predictive value of 
      miR-21 expression.
FAU - Al-Hayali, Mutaa Abdalmutaleb
AU  - Al-Hayali MA
AD  - Department of Biochemistry, Yildiz Technical University, Istanbul 34220, Turkey. 
      alhayalimuttaa@yahoo.com.
AD  - Department of Physiology, Biochemistry and Pharmacology College of Veterinary 
      Medicine, Mosul University, Mosul 09334, Iraq. alhayalimuttaa@yahoo.com.
FAU - Sozer, Volkan
AU  - Sozer V
AUID- ORCID: 0000-0002-2286-2416
AD  - Department of Biochemistry, Yildiz Technical University, Istanbul 34220, Turkey. 
      volkansozer2000@yahoo.com.
FAU - Durmus, Sinem
AU  - Durmus S
AUID- ORCID: 0000-0002-9272-9098
AD  - Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, Istanbul 34098, Turkey. durmus.sinem@gmail.com.
FAU - Erdenen, Fusun
AU  - Erdenen F
AUID- ORCID: 0000-0003-1633-6409
AD  - Istanbul Training and research Hospital, Department of Internal Medicine, 
      Istanbul 34098, Turkey. fusunozerdenen@hotmail.com.
FAU - Altunoglu, Esma
AU  - Altunoglu E
AD  - Istanbul Training and research Hospital, Department of Internal Medicine, 
      Istanbul 34098, Turkey. esmaaltunoglu@yahoo.com.
FAU - Gelisgen, Remise
AU  - Gelisgen R
AD  - Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, Istanbul 34098, Turkey. remisagelisgen@hotmail.com.
FAU - Atukeren, Pinar
AU  - Atukeren P
AD  - Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, Istanbul 34098, Turkey. p_atukeren@yahoo.com.
FAU - Atak, Palmet Gun
AU  - Atak PG
AD  - Department of Biochemistry, Faculty of Medicine, Istanbul Bilim University, 
      Istanbul 34394, Turkey. palmetgun@gmail.com.
FAU - Uzun, Hafize
AU  - Uzun H
AUID- ORCID: 0000-0002-1347-8498
AD  - Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, Istanbul 34098, Turkey. huzun59@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190517
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Biomarkers)
RN  - 0 (Cell-Free Nucleic Acids)
RN  - 0 (MIRN1 microRNA, human)
RN  - 0 (MIRN21 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Aged
MH  - Asymptomatic Diseases
MH  - Biomarkers/blood
MH  - Cell-Free Nucleic Acids/*blood
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Heart Failure/*blood/complications/epidemiology
MH  - Humans
MH  - Male
MH  - MicroRNAs/*blood
MH  - Middle Aged
PMC - PMC6571732
OTO - NOTNLM
OT  - NT-proBNP
OT  - acute heart failure
OT  - asymptomatic type 2 diabetes mellitus
OT  - galectin-3
OT  - miRNA-1
OT  - miRNA-21
OT  - silent coronary artery disease
COIS- The authors declare no conflicts of interest.
EDAT- 2019/05/22 06:00
MHDA- 2020/02/01 06:00
PMCR- 2019/05/01
CRDT- 2019/05/22 06:00
PHST- 2019/04/25 00:00 [received]
PHST- 2019/05/10 00:00 [revised]
PHST- 2019/05/15 00:00 [accepted]
PHST- 2019/05/22 06:00 [entrez]
PHST- 2019/05/22 06:00 [pubmed]
PHST- 2020/02/01 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - biom9050193 [pii]
AID - biomolecules-09-00193 [pii]
AID - 10.3390/biom9050193 [doi]
PST - epublish
SO  - Biomolecules. 2019 May 17;9(5):193. doi: 10.3390/biom9050193.