PMID- 31111002
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 15
IP  - 2
DP  - 2019 Apr
TI  - Effects of treadmill exercise on the anxiety-like behavior through modulation of 
      GSK3beta/beta-catenin signaling in the maternal separation rat pup.
PG  - 206-212
LID - 10.12965/jer.1938094.047 [doi]
AB  - Maternal separation causes depression and anxiety. Exercise ameliorates maternal 
      separation-induced depression. In this study, we investigated the effect of 
      treadmill exercise on anxiety-like behavior in relation with glycogen synthase 
      kinase 3 beta (GSK3beta)/beta-catenin pathway using maternal separation rat pups. For 
      this study, elevated plus maze test, immunohistochemistry for serotonin 
      (5-hydroxytryptamine, 5-HT), tryptophan hydroxylase (TPH), and western blot for 
      total GSK3beta (t-GSK3beta), phosphorylated GSK3beta (p-GSK3beta), total beta-catenin 
      (t-beta-catenin), and phosphorylated beta-catenin (p-beta-catenin) were conducted. The rat 
      pups in the exercise groups were scheduled to run on a treadmill for 30 min once 
      a day for 10 days, starting on postnatal day 21. For the rat pups in the 
      fluoxetine-treated group, fluoxetine was orally administrated once a day for 10 
      consecutive days, starting on postnatal day 21. Anxiety-like behavior was 
      appeared in the rat pups by maternal separation. Maternal separation suppressed 
      5-HT and TPH expression in the dorsal raphe. Maternal separation suppressed 
      phosphorylation of GSK3beta and increased phosphorylation of beta-catenin in the 
      hippocampus. However, treadmill exercise and fluoxetine treatment alleviated 
      anxiety and increased 5-HT and TPH expression in the dorsal raphe. Treadmill 
      exercise and fluoxetine treatment also enhanced GSK3beta phosphorylation and 
      suppressed beta-catenin phosphorylation in the hippocampus. In this study, 
      alleviating effect of treadmill exercise on maternal separation-induced anxiety 
      appeared through enhancing 5-HT expression and GSK3beta phosphorylation, and then 
      inhibiting beta-catenin phosphorylation. These results showed that treadmill 
      exercise relieves anxiety through GSK3beta/beta-catenin pathway. Treadmill exercise 
      showed similar ameliorating effect on anxiety-like behavior as fluoxetine.
FAU - Wang, Lin Ru
AU  - Wang LR
AD  - Department of Sport & Health Care, College of Art & Culture, Sangmyung 
      University, Seoul, Korea.
FAU - Kim, Sang-Hoon
AU  - Kim SH
AD  - Department of Sport & Health Care, College of Art & Culture, Sangmyung 
      University, Seoul, Korea.
FAU - Baek, Seung-Soo
AU  - Baek SS
AUID- ORCID: 0000-0002-1340-2098
AD  - Department of Sport & Health Care, College of Art & Culture, Sangmyung 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20190426
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC6509449
OTO - NOTNLM
OT  - Anxiety
OT  - Exercise
OT  - Glycogen synthase kinase 3beta
OT  - Maternal separation
OT  - Serotonin
OT  - beta-Catenin
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2019/05/22 06:00
MHDA- 2019/05/22 06:01
PMCR- 2019/04/26
CRDT- 2019/05/22 06:00
PHST- 2019/01/12 00:00 [received]
PHST- 2019/02/26 00:00 [accepted]
PHST- 2019/05/22 06:00 [entrez]
PHST- 2019/05/22 06:00 [pubmed]
PHST- 2019/05/22 06:01 [medline]
PHST- 2019/04/26 00:00 [pmc-release]
AID - jer-15-2-206 [pii]
AID - 10.12965/jer.1938094.047 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2019 Apr 26;15(2):206-212. doi: 10.12965/jer.1938094.047. 
      eCollection 2019 Apr.