PMID- 31111082
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2352-3409 (Electronic)
IS  - 2352-3409 (Linking)
VI  - 24
DP  - 2019 Jun
TI  - Data on the negative regulation of invadopodia activity by MLCK.
PG  - 103939
LID - 10.1016/j.dib.2019.103939 [doi]
LID - 103939
AB  - Actomyosin contractility can promote extracellular matrix (ECM) degradation by 
      invadopodia in cancer cells. However, we previously found that inhibiting myosin 
      light chain kinase (MLCK) with siRNA did not change force generation by the head 
      and neck squamous cell carcinoma (HNSCC) cell line SCC-61. We provide data here 
      that this targeted method of MLCK knockdown (KD) resulted in a significant 
      increase in the amount of ECM degradation, number of actively degrading 
      invadopodia, and the number of total invadopodia formed. These data are related 
      to the research article entitled "Matrix rigidity differentially regulates 
      invadopodia activity through ROCK1 and ROCK2" Jerrell and Parekh, 2016.
FAU - Jerrell, Rachel J
AU  - Jerrell RJ
AD  - Department of Otolaryngology, Vanderbilt University Medical Center, US.
FAU - Parekh, Aron
AU  - Parekh A
AD  - Department of Otolaryngology, Vanderbilt University Medical Center, US.
AD  - Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, US.
AD  - Department of Biomedical Engineering, Vanderbilt University, US.
LA  - eng
GR  - K25 CA143412/CA/NCI NIH HHS/United States
GR  - UL1 TR000445/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20190424
PL  - Netherlands
TA  - Data Brief
JT  - Data in brief
JID - 101654995
PMC - PMC6510963
OTO - NOTNLM
OT  - Cancer
OT  - Contractility
OT  - Invadopodia
OT  - Invasion
OT  - MLCK
EDAT- 2019/05/22 06:00
MHDA- 2019/05/22 06:01
PMCR- 2019/04/24
CRDT- 2019/05/22 06:00
PHST- 2019/03/18 00:00 [received]
PHST- 2019/04/10 00:00 [revised]
PHST- 2019/04/15 00:00 [accepted]
PHST- 2019/05/22 06:00 [entrez]
PHST- 2019/05/22 06:00 [pubmed]
PHST- 2019/05/22 06:01 [medline]
PHST- 2019/04/24 00:00 [pmc-release]
AID - S2352-3409(19)30290-2 [pii]
AID - 103939 [pii]
AID - 10.1016/j.dib.2019.103939 [doi]
PST - epublish
SO  - Data Brief. 2019 Apr 24;24:103939. doi: 10.1016/j.dib.2019.103939. eCollection 
      2019 Jun.