PMID- 31111184
OWN - NLM
STAT- MEDLINE
DCOM- 20201001
LR  - 20201001
IS  - 1433-7347 (Electronic)
IS  - 0942-2056 (Linking)
VI  - 28
IP  - 5
DP  - 2020 May
TI  - Minimal clinically important differences and substantial clinical benefits for 
      Knee Society Scores.
PG  - 1473-1478
LID - 10.1007/s00167-019-05543-x [doi]
AB  - PURPOSE: There is a paucity of literature defining the minimal clinically 
      important difference (MCID) for the Knee Society Scores (KSS) after total knee 
      arthroplasty (TKA), and no data on the substantial clinical benefit (SCB) for KSS 
      have been reported. The purpose of this study was to determine MCID and SCB for 
      the KSS in patients with primary TKA. METHODS: The median age of patients was 
      71.6 (range 50-88) years, and 60.3% were females 507 patients with TKA were 
      prospectively enrolled. Patients completed the KSS before surgery and at second 
      postoperative year. The MCID values of the KSS were estimated using anchor-based 
      method, distribution-based method and receiver operating characteristic (ROC) 
      curve analysis with calculation of the area under curve (AUC). SCB was estimated 
      using ROC. RESULTS: The MCID for KSS-knee score was 7.2 points by the 
      anchor-based method, 7.2 by the distribution-based method, and using a ROC 
      analysis the cutoff point was 8.9 points with an AUC of 0.75. For KSS-function 
      score, the MCID values were 9.7, 6.3, and 10.3 (AUC 0.71), respectively. SCB 
      values were 39.7 points (AUC 0.74) for the KSS-knee score, and 38.6 (AUC 0.76) 
      for the KSS-function score. Logistic regression showed age and Charlson index to 
      negatively affect the changes in KSS. CONCLUSION: Different methods for MCID 
      calculation lead to different results. With the use of ROC curve analysis, 
      patients with an improvement of at least 9 points for KSS-knee and 10 points for 
      KSS-function scores experience a clinically important change, whereas those who 
      have at least an improvement of 40 points for KSS-knee and 39 points for 
      KSS-function scores experience a substantial clinical benefit. These findings can 
      ensure clinical improvement from the patient's perspective and also aid in 
      interpreting results from clinical studies. LEVEL OF EVIDENCE: III.
FAU - Lizaur-Utrilla, Alejandro
AU  - Lizaur-Utrilla A
AUID- ORCID: 0000-0003-4798-2702
AD  - Department of Orthopaedic Surgery, Elda University Hospital, Ctra Elda-Sax s/n, 
      03600, Elda, Alicante, Spain. lizaur1@telefonica.net.
AD  - Department of Traumatology and Orthopaedia, Miguel Hernandez University, Elche, 
      Alicante, Spain. lizaur1@telefonica.net.
FAU - Gonzalez-Parreno, Santiago
AU  - Gonzalez-Parreno S
AD  - Department of Orthopaedic Surgery, Elda University Hospital, Ctra Elda-Sax s/n, 
      03600, Elda, Alicante, Spain.
FAU - Martinez-Mendez, Daniel
AU  - Martinez-Mendez D
AD  - Department of Orthopaedic Surgery, Elda University Hospital, Ctra Elda-Sax s/n, 
      03600, Elda, Alicante, Spain.
FAU - Miralles-Munoz, Francisco A
AU  - Miralles-Munoz FA
AD  - Department of Orthopaedic Surgery, Elda University Hospital, Ctra Elda-Sax s/n, 
      03600, Elda, Alicante, Spain.
FAU - Lopez-Prats, Fernando A
AU  - Lopez-Prats FA
AD  - Department of Traumatology and Orthopaedia, Miguel Hernandez University, Elche, 
      Alicante, Spain.
LA  - eng
PT  - Journal Article
DEP - 20190520
PL  - Germany
TA  - Knee Surg Sports Traumatol Arthrosc
JT  - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
JID - 9314730
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthroplasty, Replacement, Knee/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Osteoarthritis, Knee/*surgery
MH  - Prognosis
MH  - ROC Curve
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Functional outcome
OT  - Knee Society Scores
OT  - MCID
OT  - Minimal clinically important difference
OT  - Patient-related outcome
OT  - Total knee arthroplasty
EDAT- 2019/05/22 06:00
MHDA- 2020/10/02 06:00
CRDT- 2019/05/22 06:00
PHST- 2019/01/16 00:00 [received]
PHST- 2019/05/14 00:00 [accepted]
PHST- 2019/05/22 06:00 [pubmed]
PHST- 2020/10/02 06:00 [medline]
PHST- 2019/05/22 06:00 [entrez]
AID - 10.1007/s00167-019-05543-x [pii]
AID - 10.1007/s00167-019-05543-x [doi]
PST - ppublish
SO  - Knee Surg Sports Traumatol Arthrosc. 2020 May;28(5):1473-1478. doi: 
      10.1007/s00167-019-05543-x. Epub 2019 May 20.