PMID- 31111486
OWN - NLM
STAT- MEDLINE
DCOM- 20200630
LR  - 20200630
IS  - 1469-1809 (Electronic)
IS  - 0003-4800 (Linking)
VI  - 83
IP  - 6
DP  - 2019 Nov
TI  - Association between the BHMT gene rs3733890 polymorphism and the efficacy of oral 
      folate therapy in patients with hyperhomocysteinemia.
PG  - 434-444
LID - 10.1111/ahg.12326 [doi]
AB  - Oral folate is currently the most common treatment for hyperhomocysteinemia 
      (HHcy), which seriously threatens human health, but its efficacy is 
      unsatisfactory. Betaine-homocysteine methyltransferase (BHMT) is a key enzyme 
      that regulates Hcy metabolism. We investigated the association between the BHMT 
      rs3733890 and the efficacy of oral folate therapy for HHcy in the Chinese Han 
      population and analysed the effects of gene-environmental interactions on the 
      efficacy. Blood samples were collected from 1071 eligible patients at baseline, 
      and these individuals received subsequent folate treatment for 90 days. A total 
      of 638 patients included in the final analysis were grouped into the treatment 
      success group or the treatment failure group based on posttreatment Hcy levels. 
      Hcy concentrations were measured by fluorescence polarization immunoassay. 
      Time-of-flight mass spectrometry (MassArray system) was used to assess the 
      genotype of BHMT rs3733890. Stratified analyses based on additive models and 
      generalized multifactor dimensionality reduction were used to explore 
      gene-environmental interactions. The genotype distribution presented distinct 
      differences in the two groups. The mutant genotype and allele had significantly 
      increased risk of treatment failure (p < 0.05). Furthermore, synergistic effects 
      of the BHMT rs3733890 polymorphism with environmental risk factors (smoking, 
      drinking, past history) on the efficacy of therapy were also found. However, 
      future, large well-designed studies, as well as mechanistic studies, are still 
      needed to validate our findings.
CI  - (c) 2019 John Wiley & Sons Ltd/University College London.
FAU - Ren, Bingnan
AU  - Ren B
AUID- ORCID: 0000-0003-2651-1637
AD  - Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Tian, Dandan
AU  - Tian D
AD  - People's Hospital of Henan Province, Zhengzhou, Henan, China.
FAU - Wang, Lianke
AU  - Wang L
AD  - Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Han, Han
AU  - Han H
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Wang, Wenhua
AU  - Wang W
AD  - Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Tian, Huizi
AU  - Tian H
AD  - Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Yue, Limin
AU  - Yue L
AD  - Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Zhang, Weidong
AU  - Zhang W
AD  - Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
LA  - eng
GR  - 132102310431/Natural Science Foundation of Henan Province/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190520
PL  - England
TA  - Ann Hum Genet
JT  - Annals of human genetics
JID - 0416661
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 2.1.1.5 (BHMT protein, human)
RN  - EC 2.1.1.5 (Betaine-Homocysteine S-Methyltransferase)
SB  - IM
MH  - Administration, Oral
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Betaine-Homocysteine S-Methyltransferase/*genetics
MH  - Comorbidity
MH  - Environment
MH  - Female
MH  - Folic Acid/administration & dosage/*therapeutic use
MH  - Humans
MH  - Hyperhomocysteinemia/*drug therapy/*genetics
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Treatment Outcome
EDAT- 2019/05/22 06:00
MHDA- 2020/07/01 06:00
CRDT- 2019/05/22 06:00
PHST- 2018/12/02 00:00 [received]
PHST- 2019/04/14 00:00 [revised]
PHST- 2019/04/26 00:00 [accepted]
PHST- 2019/05/22 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2019/05/22 06:00 [entrez]
AID - 10.1111/ahg.12326 [doi]
PST - ppublish
SO  - Ann Hum Genet. 2019 Nov;83(6):434-444. doi: 10.1111/ahg.12326. Epub 2019 May 20.