PMID- 31112049
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20191104
IS  - 2169-141X (Electronic)
IS  - 2169-1401 (Linking)
VI  - 47
IP  - 1
DP  - 2019 Dec
TI  - Synthesis, identification and application of the novel metal-organic framework 
      Fe(3)O(4)@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of 
      antibacterial activity.
PG  - 2024-2030
LID - 10.1080/21691401.2019.1617729 [doi]
AB  - Today, metal-organic frameworks (MOFs) for the release of drugs have been studied 
      extensively. In this research, we have investigated the novel magnetic framework 
      including Fe(3)O(4)@PAA@ZIF-8 for the delivery of ciprofloxacin (CIP) antibiotic. 
      Moreover, the antibacterial activity of Fe(3)O(4)@PAA@ZIF-8 and 
      Fe(3)O(4)@PAA@ZIF-8@CIP screened against Staphylococcus aureus ( S. aureus) and 
      Escherichia coli ( E. coli) bacteria. The structure of the nano carrier, as well 
      as the encapsulation of the drug in the framework was confirmed by the 
      Fourier-transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy 
      (UV-Vis), Energy-dispersive X-ray spectroscopy (EDX), X-ray crystallography 
      (XRD), Scanning electron microscope (SEM) and Brunauer-Emmett-Teller (BET) 
      analysis. The results of this study showed that 93% of the CIP was loaded on the 
      synthesized framework. Drug release was done at pH: 7.4 and pH: 5 within 2 d, 
      resulting about 73% release of the drug.
FAU - Esfahanian, Maryam
AU  - Esfahanian M
AD  - a Department of Chemistry, Islamic Azad University , Qom , Iran.
FAU - Ghasemzadeh, Mohammad Ali
AU  - Ghasemzadeh MA
AD  - a Department of Chemistry, Islamic Azad University , Qom , Iran.
FAU - Razavian, Seyyed Mohammad Hossein
AU  - Razavian SMH
AD  - b Department of Microbiology, Islamic Azad University , Qom , Iran.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Artif Cells Nanomed Biotechnol
JT  - Artificial cells, nanomedicine, and biotechnology
JID - 101594777
RN  - 0 (Acrylic Resins)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Metal-Organic Frameworks)
RN  - 4Q93RCW27E (carbopol 940)
RN  - 5E8K9I0O4U (Ciprofloxacin)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Acrylic Resins/*chemistry
MH  - Anti-Bacterial Agents/chemistry/pharmacology
MH  - Chemistry Techniques, Synthetic
MH  - Ciprofloxacin/*chemistry/*pharmacology
MH  - Drug Carriers/chemical synthesis/chemistry
MH  - Drug Liberation
MH  - Escherichia coli/drug effects
MH  - Ferrosoferric Oxide/*chemistry
MH  - Kinetics
MH  - Metal-Organic Frameworks/*chemical synthesis/*chemistry
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Staphylococcus aureus/drug effects
OTO - NOTNLM
OT  - Ciprofloxacin
OT  - FeO@PAA@ZIF-8
OT  - MOFs
OT  - antibacterial activity
OT  - drug delivery
OT  - zeolite imidazole
EDAT- 2019/05/22 06:00
MHDA- 2019/11/05 06:00
CRDT- 2019/05/22 06:00
PHST- 2019/05/22 06:00 [entrez]
PHST- 2019/05/22 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
AID - 10.1080/21691401.2019.1617729 [doi]
PST - ppublish
SO  - Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2024-2030. doi: 
      10.1080/21691401.2019.1617729.