PMID- 31112373
OWN - NLM
STAT- MEDLINE
DCOM- 20200803
LR  - 20210109
IS  - 2045-7634 (Electronic)
IS  - 2045-7634 (Linking)
VI  - 8
IP  - 8
DP  - 2019 Jul
TI  - Nomograms for predicting long-term overall survival and cancer-specific survival 
      in lip squamous cell carcinoma: A population-based study.
PG  - 4032-4042
LID - 10.1002/cam4.2260 [doi]
AB  - BACKGROUND: The goal of this study was to establish and validate two nomograms 
      for predicting the long-term overall survival (OS) and cancer-specific survival 
      (CSS) in lip squamous cell carcinoma (LSCC). METHODS: This study selected 4175 
      patients who were diagnosed with LSCC between 2004 and 2015 in the SEER 
      (Surveillance, Epidemiology, and End Results) database. The patients were 
      allocated randomly to a training cohort and validation cohort. Variables were 
      selected using a backward stepwise method in a Cox regression model. Based on the 
      predictive model with the identified prognostic factors, nomograms were 
      established to predict the 3-, 5-, and 8-year survival OS and CSS rates of LSCC 
      patients. The accuracy of the nomograms was evaluated based on the consistency 
      index (C-index), while their prediction accuracy was evaluated using calibration 
      plots. Decision curve analyses (DCAs) were used to evaluate the performance of 
      our survival model. RESULTS: The multivariate analyses demonstrated that age at 
      diagnosis, marital status, sex, race, American Joint Committee on Cancer stage, 
      surgery status, and radiotherapy status were risk factors for both OS and CSS. 
      The C-index, area under the time-dependent receiver operating characteristic 
      curve, and calibration plots demonstrated the good performance of the nomograms. 
      DCAs of both nomograms further showed that they exhibited good 3-, 5-, and 8-year 
      net benefits. CONCLUSIONS: We have developed and validated LSCC prognosis 
      nomograms for OS and CSS for the first time. These nomograms can be valuable 
      tools for clinical practice when clinicians are helping patients to understand 
      their survival risk for the next 3, 5, and 8 years.
CI  - (c) 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
FAU - Hu, Chuan-Yu
AU  - Hu CY
AD  - Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
AD  - Stomatology Center, Tongji Hospital, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, China.
FAU - Pan, Zhen-Yu
AU  - Pan ZY
AD  - Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      Shaanxi, China.
AD  - Department of Pharmacy, The Affiliated Children Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Yang, Jin
AU  - Yang J
AD  - Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      Shaanxi, China.
FAU - Chu, Xiu-Hong
AU  - Chu XH
AD  - Department of Nursing, Yeda Hospital, Yantai, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      Shaanxi, China.
AD  - Department of Orthopaedics, Baoji Municipal Central Hospital, Baoji, China.
FAU - Tao, Xue-Jin
AU  - Tao XJ
AD  - Stomatology Center, Tongji Hospital, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, China.
FAU - Chen, Wei-Min
AU  - Chen WM
AD  - Stomatology Center, Tongji Hospital, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, China.
FAU - Li, Yuan-Jie
AU  - Li YJ
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
FAU - Lyu, Jun
AU  - Lyu J
AUID- ORCID: 0000-0002-2237-8771
AD  - Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      Shaanxi, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190521
PL  - United States
TA  - Cancer Med
JT  - Cancer medicine
JID - 101595310
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*epidemiology/mortality/pathology
MH  - Female
MH  - Humans
MH  - Lip Neoplasms/*epidemiology/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - ROC Curve
MH  - SEER Program
PMC - PMC6639254
OTO - NOTNLM
OT  - SEER
OT  - cancer-specific survival
OT  - lip squamous cell carcinoma
OT  - nomogram
OT  - overall survival
COIS- The author reports no conflict of interest in this work.
EDAT- 2019/05/22 06:00
MHDA- 2020/08/04 06:00
PMCR- 2019/05/21
CRDT- 2019/05/22 06:00
PHST- 2019/01/24 00:00 [received]
PHST- 2019/03/30 00:00 [revised]
PHST- 2019/05/06 00:00 [accepted]
PHST- 2019/05/22 06:00 [pubmed]
PHST- 2020/08/04 06:00 [medline]
PHST- 2019/05/22 06:00 [entrez]
PHST- 2019/05/21 00:00 [pmc-release]
AID - CAM42260 [pii]
AID - 10.1002/cam4.2260 [doi]
PST - ppublish
SO  - Cancer Med. 2019 Jul;8(8):4032-4042. doi: 10.1002/cam4.2260. Epub 2019 May 21.