PMID- 31114273
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - Genetic variants linked to T2DM risk in Kurdish populations.
PG  - 431-437
LID - 10.2147/DMSO.S189170 [doi]
AB  - Background: The polymorphisms of the C-C chemokine receptor type 5 (CCR5) and the 
      insulin receptor substrate 1 (IRS1) have been studied as candidates for the 
      susceptibility to develop type 2 diabetes mellitus (T2DM). CCR5 is a chemokine 
      receptor, and the polymorphisms in the promoter region of this receptor are being 
      studied as candidates for the susceptibility to develop T2DM. Also, IRS1 is a 
      critical factor in the signaling pathway for insulin, and mutations in this gene 
      have been reported, which contribute to the ability to develop T2DM. The aim of 
      the current study was to determine the relationship between CCR5 (59029A/G) and 
      IRS1 (rs10498210) polymorphisms with T2DM in Sanandajian patients. Methods: 
      Genomic DNA was isolated from 200 healthy individuals and 220 Kurdish T2DM 
      patients by salt extraction method and the polymorphisms were examined by 
      restriction fragment length polymorphism (RFLP) method and then the results were 
      analyzed using Chi-square test. Results: The frequency of AA genotype in 220 
      Kurdish patients for both genes CCR5 (OR=1.9, P=0.02) and IRS1 (OR [95% CI]=2.62, 
      P=0.02) were significantly more than controls. There was no significant 
      association between AG or GG genotypes in with T2DM. Conclusion: The presence of 
      AA homozygote alleles in both loci of IRS1 (rs10498210) and CCR5 (59029A/G) genes 
      increased the risk of T2DM.
FAU - Golsheh, Shadi
AU  - Golsheh S
AD  - Department of Biology, Kurdistan Science and Research Branch, Islamic Azad 
      University, Sanandaj, Iran.
FAU - Keshavarzi, Fatemeh
AU  - Keshavarzi F
AD  - Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20190405
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
RIN - Diabetes Metab Syndr Obes. 2019 Jul 08;12:1073. PMID: 31360072
PMC - PMC6497875
OTO - NOTNLM
OT  - CCR5 (59029A/G)
OT  - IRS1 (rs10498210)
OT  - Kurdish patients
OT  - type 2 diabetes
COIS- The authors report no conflicts of interest in this work.
EDAT- 2019/05/23 06:00
MHDA- 2019/05/23 06:01
PMCR- 2019/04/05
CRDT- 2019/05/23 06:00
PHST- 2018/09/29 00:00 [received]
PHST- 2019/03/05 00:00 [accepted]
PHST- 2019/05/23 06:00 [entrez]
PHST- 2019/05/23 06:00 [pubmed]
PHST- 2019/05/23 06:01 [medline]
PHST- 2019/04/05 00:00 [pmc-release]
AID - 189170 [pii]
AID - 10.2147/DMSO.S189170 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Apr 5;12:431-437. doi: 10.2147/DMSO.S189170. 
      eCollection 2019.