PMID- 31114431
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1426-3912 (Print)
IS  - 1644-4124 (Electronic)
IS  - 1426-3912 (Linking)
VI  - 44
IP  - 1
DP  - 2019
TI  - Anti-inflammatory activity of elicited soybean (Glycine max) extract on Balb/C 
      mice (Mus musculus) with high-fat and -fructose diet.
PG  - 7-14
LID - 10.5114/ceji.2019.84010 [doi]
AB  - Obesity causes adipocyte hypertrophy, which leads to cell death. Consequently, 
      macrophages and lymphocytes infiltrate into the adipose tissue and elevate 
      pro-inflammatory cytokine production through TLR activation. This study aimed to 
      determine the efficacy of soybean extract, which was elicited by Saccharomyces 
      cerevisiae and light, as an anti-inflammatory agent in mice with a high-fat and 
      -fructose diet (HFFD). The elicited soybean extract (ESE) was administered orally 
      to mice for four weeks after being given an HFFD for 20 weeks. Three different 
      doses were used: (1) low-dose (78 mg/kg BW); (2) normal dose (104 mg/kg BW); and 
      (3) high dose (130 mg/kg BW). HFFD mice model treated with simvastatin 2.8 mg/kg 
      BW considered as drug control. After 24 weeks, the lymphocytes were isolated and 
      the relative number of CD4(+)TLR3(+) T, CD4(+)TLR4(+) T, CD4(+)TNF-alpha (+) T, and 
      CD4(+)IFN-gamma (+) T cells were analysed using flow cytometry. The results showed 
      that the HFFD mouse model had an increased number of CD4(+)TLR3(+) T, 
      CD4(+)TLR4(+) T, CD4(+)TNF-alpha (+) T, and CD4(+)IFN-gamma (+) T cells. ESE 
      administration decreased the relative number of CD4(+)TLR3(+) T, CD4(+)TLR4(+) T, 
      CD4(+)TNF-alpha (+) T, and CD4(+)IFN-gamma (+) T cells. The normal dose of ESE is the 
      most effective dose in suppressing inflammation compared to positive controls. 
      ESE 104 mg/kg BW can be considered as an alternative herbal medicine that may 
      suppress inflammation in HFFD mice.
FAU - Nur'aini, Farida D
AU  - Nur'aini FD
AD  - Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya 
      University, East Java, Indonesia.
FAU - Rahayu, Sri
AU  - Rahayu S
AD  - Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya 
      University, East Java, Indonesia.
FAU - Rifa'i, Muhaimin
AU  - Rifa'i M
AD  - Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya 
      University, East Java, Indonesia.
AD  - Biosystem, Brawijaya University, East Java, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20190415
PL  - Poland
TA  - Cent Eur J Immunol
JT  - Central-European journal of immunology
JID - 9702239
PMC - PMC6526585
OTO - NOTNLM
OT  - anti-inflammatory
OT  - elicited soybean extract
OT  - high fat-fructose diet
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/23 06:00
MHDA- 2019/05/23 06:01
PMCR- 2019/01/01
CRDT- 2019/05/23 06:00
PHST- 2017/03/08 00:00 [received]
PHST- 2017/06/08 00:00 [accepted]
PHST- 2019/05/23 06:00 [entrez]
PHST- 2019/05/23 06:00 [pubmed]
PHST- 2019/05/23 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 84010 [pii]
AID - 10.5114/ceji.2019.84010 [doi]
PST - ppublish
SO  - Cent Eur J Immunol. 2019;44(1):7-14. doi: 10.5114/ceji.2019.84010. Epub 2019 Apr 
      15.