PMID- 31115387
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2303-9027 (Print)
IS  - 2226-7190 (Electronic)
IS  - 2226-7190 (Linking)
VI  - 8
IP  - 4
DP  - 2019 Jul-Aug
TI  - Adverse events with lumen-apposing metal stents in endoscopic gallbladder 
      drainage: A systematic review and meta-analysis.
PG  - 241-248
LID - 10.4103/eus.eus_63_18 [doi]
AB  - BACKGROUND: Lumen-apposing metal stents (LAMS) are rapidly being used in 
      endoscopic interventional drainage procedures and have started to replace the 
      self-expanding metal stents (SEMSs). Its use in gallbladder drainage (GBD) is 
      limited by lack of good-quality studies, and data are scarce on its safety. 
      METHODS: We conducted a comprehensive search of multiple electronic databases and 
      conference proceedings including PubMed, Embase, and Web of Science databases 
      (from inception through July 2018) to identify studies that reported on the use 
      of LAMS in GBD. The outcomes measured were the pooled rates of all adverse events 
      (AEs), pooled rates of early AEs and pooled rates of delayed AEs. RESULTS: A 
      total of 8 studies (393 patients) were included. The pooled rate of all AEs was 
      12.7% (95% CI 8.4-18.7, I(2)= 7.7) compared to 17.5% (95% CI 10.2-28.2, I(2)= 
      65.1) with other SEMS, P = 0.39. The rate of early AEs with LAMS in endoscopic 
      ultrasound-GBD (EUS-GBD) was 6.5% (95% CI 4.2-10, I(2)= 1.2), and the rate of 
      delayed AEs was 8.3% (95% CI 5.8-11.9, I(2) = 4.8). The rate of recurrent 
      cholecystitis and/or cholangitis was 4.6% (95% CI 2.6-9.5, I(2)= 0) and the 
      pooled rate of death was 5% (95% CI 2.6-9.5, I(2) = 36.4). CONCLUSION: We report 
      an overall AE rate of 13% with LAMS in EUS-GBD. Early AE risk appears to be 6.5% 
      and delayed AE risk appears to be 8%. Our results are analyzed out of 
      good-quality studies, with minimal to zero heterogeneity.
FAU - Mohan, Babu P
AU  - Mohan BP
AD  - Inpatient Medicine, Banner University Medical Center/ University of Arizona, 
      Tucson, Arizona, USA.
FAU - Asokkumar, Ravishankar
AU  - Asokkumar R
AD  - Division of Gastroenterology and Hepatology, Singapore General Hospital, 
      Singapore.
FAU - Shakhatreh, Mohammed
AU  - Shakhatreh M
AD  - Department of Hospital Medicine, Rapides Regional Medical Center, Alexandria, 
      Louisiana, USA.
FAU - Garg, Rajat
AU  - Garg R
AD  - Department of Hospital Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, 
      USA.
FAU - Ponnada, Suresh
AU  - Ponnada S
AD  - Department of Hospital Medicine, Carilion Roanoke Memorial Hospital, Roanoke, 
      Virginia, USA.
FAU - Navaneethan, Udayakumar
AU  - Navaneethan U
AD  - Center for Interventional Endoscopy, Florida Hospital, Orlando, Florida, USA.
FAU - Adler, Douglas G
AU  - Adler DG
AD  - Division of Gastroenterology and Hepatology, University of Utah School of 
      Medicine, Salt Lake City, Utah, USA.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Endosc Ultrasound
JT  - Endoscopic ultrasound
JID - 101622292
PMC - PMC6714485
OTO - NOTNLM
OT  - Adverse events
OT  - gallbladder drainage
OT  - lumen-apposing metal stents
OT  - self-expanding metal stents
COIS- None
EDAT- 2019/05/23 06:00
MHDA- 2019/05/23 06:01
PMCR- 2019/07/01
CRDT- 2019/05/23 06:00
PHST- 2019/05/23 06:00 [pubmed]
PHST- 2019/05/23 06:01 [medline]
PHST- 2019/05/23 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 257857 [pii]
AID - EUS-8-241 [pii]
AID - 10.4103/eus.eus_63_18 [doi]
PST - ppublish
SO  - Endosc Ultrasound. 2019 Jul-Aug;8(4):241-248. doi: 10.4103/eus.eus_63_18.