PMID- 31116257
OWN - NLM
STAT- MEDLINE
DCOM- 20190710
LR  - 20230106
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 52
IP  - 6
DP  - 2019
TI  - Evaluation of the effects of Uncaria rhynchophylla alkaloid extract on 
      LPS-induced preeclampsia symptoms and inflammation in a pregnant rat model.
PG  - e8273
LID - S0100-879X2019000600602 [pii]
LID - 10.1590/1414-431X20198273 [doi]
LID - e8273
AB  - Excessive pro-inflammatory cytokines result in adverse pregnancy outcomes, 
      including preeclampsia-like phenotypes, and fetal growth restriction. 
      Anti-inflammation might be an effective therapy. The aim of this research was to 
      investigate whether Uncaria rhynchophylla alkaloid extract (URE), a highly safe 
      anti-inflammation constituent of the herb, can inhibit inflammation and improve 
      clinical characteristics of preeclampsia in a lipopolysaccharide (LPS)-induced 
      preeclampsia rat model. The rat model was established by daily administration of 
      LPS (1 mug/kg body weight per day) from gestational day (GD) 14 to 19. Different 
      doses of URE (35, 70, and 140 mg/kg body weight per day) were administered from 
      GD 14 to GD 19. The effects of URE on proteinuria, maternal hypertension, 
      pregnancy outcomes, as well as pro-inflammatory cytokines levels in serum and 
      placenta were measured. High-dose URE (HURE) treatment decreased LPS-induced mean 
      24-h proteinuria and systolic blood pressure, and increased fetal weight, 
      placental weight, and the number of live pups (P<0.05). Moreover, increased serum 
      and placental levels of interleukin (IL)-6, IL-1beta, tumor necrosis factor-alpha, and 
      interferon-gamma in the LPS-treated group were obviously inhibited after HURE 
      administration (P<0.01). URE improved preeclampsia symptoms and mitigated 
      inflammatory responses in the LPS-induced preeclampsia rat model, which suggests 
      that the anti-inflammation effect of URE might be an alternative therapy for 
      preeclampsia.
FAU - Wu, Liang-Zhi
AU  - Wu LZ
AUID- ORCID: 0000-0002-4427-7453
AD  - Department of Obstetrics and Gynecology, 1st Affiliated Hospital of Jinan 
      University, Guangzhou, Guangdong, China.
AD  - Department of Obstetrics and Gynecology, Guangdong Second Provincial General 
      Hospital, Guangzhou, Guangdong, China.
FAU - Xiao, Xiao-Min
AU  - Xiao XM
AUID- ORCID: 0000-0003-0340-9103
AD  - Department of Obstetrics and Gynecology, 1st Affiliated Hospital of Jinan 
      University, Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20190516
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Cytokines/blood/drug effects
MH  - Disease Models, Animal
MH  - Female
MH  - Inflammation/*prevention & control
MH  - Lipopolysaccharides
MH  - Plant Extracts/*administration & dosage
MH  - Pre-Eclampsia/chemically induced/*prevention & control
MH  - Pregnancy
MH  - Rats
MH  - Uncaria/*chemistry
PMC - PMC6526749
EDAT- 2019/05/23 06:00
MHDA- 2019/07/11 06:00
PMCR- 2019/05/16
CRDT- 2019/05/23 06:00
PHST- 2018/11/19 00:00 [received]
PHST- 2019/03/07 00:00 [accepted]
PHST- 2019/05/23 06:00 [entrez]
PHST- 2019/05/23 06:00 [pubmed]
PHST- 2019/07/11 06:00 [medline]
PHST- 2019/05/16 00:00 [pmc-release]
AID - S0100-879X2019000600602 [pii]
AID - 10.1590/1414-431X20198273 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2019;52(6):e8273. doi: 10.1590/1414-431X20198273. Epub 2019 
      May 16.