PMID- 31118638
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 15
DP  - 2019
TI  - Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine 
      transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish 
      population.
PG  - 989-1000
LID - 10.2147/NDT.S194924 [doi]
AB  - Background: Excitatory amino acid transporter 2 encoded by SLC1A2 is responsible 
      for approximately 90% of glutamate uptake. Glycine transporter 1, encoded by 
      SLC6A9, is responsible for maintaining a low concentration of the 
      N-methyl-D-aspartate receptor (NMDAR) co-agonist - glycine in the synaptic cleft, 
      suggesting its participation in the development of the NMDARs hypofunction 
      described in schizophrenia. Aim: The aim of this study was to evaluate whether 
      the functional polymorphism-181 A/C (rs4354668) of the SLC1A2 and the rs2486001 
      (IVS3+411 G/A) in the SLC6A9 are involved in schizophrenia development and its 
      clinical picture in the Polish population. Methods: The study group consisted of 
      393 unrelated Caucasian patients (157 [39.9%] females and 236 [60.1%] males; mean 
      age 41+/-12) diagnosed with schizophrenia according to the DSM-5, and 462 healthy 
      controls. The results of the Positive and Negative Syndrome Scale (PANSS) were 
      presented in the five-dimensional model. Polymorphisms of SLC1A2 and SLC6A9 were 
      genotyped with the use of PCR-RFLP assay. Results: There were no statistically 
      significant differences in the frequency of genotypes and alleles between the 
      patients and controls for SLC1A2 and SLC6A9 polymorphisms in either the entire 
      sample or after stratification according to gender. In the haplotype analysis, 
      men with CA haplotype had more than 1.5 higher risk to develop schizophrenia than 
      women (OR=1.63 [95% CI=1.17-2.27, p<0.05]). The influence of gender, genotypes of 
      both analyzed polymorphisms and gender x genotype interactions on individual 
      dimensions of the PANSS scale has not been observed. Also, there was no 
      association of either polymorphism with suicide attempts. Conclusion: The results 
      of the present study did not indicate an association of polymorphism-181 A/C 
      (rs4354668) in SLC1A2 and rs2486001 in SLC6A9 with onset of schizophrenia and its 
      psychopathology in a Polish population.
FAU - Merk, Wojciech
AU  - Merk W
AUID- ORCID: 0000-0001-7080-1063
AD  - Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, 
      Medical University of Silesia, Katowice, Poland.
FAU - Kucia, Krzysztof
AU  - Kucia K
AUID- ORCID: 0000-0001-5618-2833
AD  - Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, 
      Medical University of Silesia, Katowice, Poland.
FAU - Medrala, Tomasz
AU  - Medrala T
AUID- ORCID: 0000-0001-6880-6471
AD  - Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, 
      Medical University of Silesia, Katowice, Poland.
FAU - Kowalczyk, Malgorzata
AU  - Kowalczyk M
AD  - Department of Medical Genetics, School of Pharmacy with the Division of 
      Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, 
      Poland.
FAU - Owczarek, Aleksander
AU  - Owczarek A
AD  - Division of Statistics, Department of Instrumental Analysis, School of Pharmacy 
      with the Division of Laboratory Medicine in Sosnowiec, Medical University of 
      Silesia, Katowice, Poland.
AD  - Department of Instrumental Analysis, School of Pharmacy with the Division of 
      Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, 
      Poland.
FAU - Kowalski, Jan
AU  - Kowalski J
AD  - Department of Medical Genetics, School of Pharmacy with the Division of 
      Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20190424
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC6499478
OTO - NOTNLM
OT  - PANSS
OT  - excitatory amino acid transporter 2
OT  - glutamate system
OT  - glycine transporter 1
OT  - polymorphism
OT  - schizophrenia
COIS- The authors report no conflicts of interest in this work.  
EDAT- 2019/05/24 06:00
MHDA- 2019/05/24 06:01
PMCR- 2019/04/24
CRDT- 2019/05/24 06:00
PHST- 2018/11/16 00:00 [received]
PHST- 2019/02/14 00:00 [accepted]
PHST- 2019/05/24 06:00 [entrez]
PHST- 2019/05/24 06:00 [pubmed]
PHST- 2019/05/24 06:01 [medline]
PHST- 2019/04/24 00:00 [pmc-release]
AID - 194924 [pii]
AID - 10.2147/NDT.S194924 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2019 Apr 24;15:989-1000. doi: 10.2147/NDT.S194924. 
      eCollection 2019.