PMID- 31118685
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1178-6930 (Print)
IS  - 1178-6930 (Electronic)
IS  - 1178-6930 (Linking)
VI  - 12
DP  - 2019
TI  - Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis 
      via regulating AMPK/mTOR pathway.
PG  - 3339-3347
LID - 10.2147/OTT.S199369 [doi]
AB  - Objective: In the present study, we aimed to investigate the potential role of 
      fatty acid synthase (FASN) in the development and progression of colorectal 
      cancer (CRC). Materials and methods: FASN levels were analyzed in human CRC 
      tissues and adjacent normal tissues by Western blots and immunohistochemistry. 
      Potential roles of FASN in regulating CRC cell proliferation and migration were 
      examined by genetic manipulation in vitro. The molecular signaling was determined 
      to understand the mechanisms of observed FASN effects. Results: FASN level was 
      upregulated in CRC tissues and high expression of FASN was significantly 
      associated with lymph node metastasis, TNM (Tumor, Node, Metastases) stage and 
      poor prognosis in patients with CRC. Knockdown of FASN attenuated CRC cell 
      proliferation and migration in vitro while FASN overexpression possessed the 
      opposite effects. FASN regulated AMP-activated protein kinase (AMPK)/mechanistic 
      target of rapamycin (mTOR) pathway in CRC cells. Conclusion: FASN enhanced CRC 
      cell proliferation and metastasis potentially through AMPK/mTOR pathway, 
      indicating that FASN/AMPK/mTOR signaling axis may serve as a potential target for 
      the treatment of CRC.
FAU - Lu, Ting
AU  - Lu T
AD  - Department of Gastroenterology, the First Affiliated Hospital of Soochow 
      University, Suzhou 215006, People's Republic of China.
FAU - Sun, Liang
AU  - Sun L
AD  - Department of General Surgery, the First Affiliated Hospital of Soochow 
      University, Suzhou 215006, People's Republic of China.
FAU - Wang, Zhiyi
AU  - Wang Z
AD  - Department of Gastroenterology, the First Affiliated Hospital of Soochow 
      University, Suzhou 215006, People's Republic of China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Gastroenterology, the First Affiliated Hospital of Soochow 
      University, Suzhou 215006, People's Republic of China.
FAU - He, Zhilong
AU  - He Z
AD  - Department of Gastroenterology, the First Affiliated Hospital of Soochow 
      University, Suzhou 215006, People's Republic of China.
FAU - Xu, Chunfang
AU  - Xu C
AD  - Department of Gastroenterology, the First Affiliated Hospital of Soochow 
      University, Suzhou 215006, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20190502
PL  - New Zealand
TA  - Onco Targets Ther
JT  - OncoTargets and therapy
JID - 101514322
PMC - PMC6504633
OTO - NOTNLM
OT  - AMPK/mTOR pathway
OT  - FASN
OT  - colorectal cancer
OT  - metastasis
OT  - proliferation
COIS- The authors report no conflicts of interest in this work. 
EDAT- 2019/05/24 06:00
MHDA- 2019/05/24 06:01
PMCR- 2019/05/02
CRDT- 2019/05/24 06:00
PHST- 2018/12/24 00:00 [received]
PHST- 2019/03/25 00:00 [accepted]
PHST- 2019/05/24 06:00 [entrez]
PHST- 2019/05/24 06:00 [pubmed]
PHST- 2019/05/24 06:01 [medline]
PHST- 2019/05/02 00:00 [pmc-release]
AID - 199369 [pii]
AID - 10.2147/OTT.S199369 [doi]
PST - epublish
SO  - Onco Targets Ther. 2019 May 2;12:3339-3347. doi: 10.2147/OTT.S199369. eCollection 
      2019.