PMID- 31119398
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20240324
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 59
IP  - 4
DP  - 2020 Jun
TI  - Correlations between urinary concentrations and dietary intakes of flavonols in 
      the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
PG  - 1481-1492
LID - 10.1007/s00394-019-02005-5 [doi]
AB  - PURPOSE: In this study, we aimed to study the correlation between acute and 
      habitual intakes of flavonols, their main food sources and their 24-h urinary 
      concentrations in an European population. METHODS: A 24-h dietary recall (24-HDR) 
      and 24-h urine samples were collected on the same day from a convenience 
      subsample of 475 men and women from four countries (France, Italy, Greece and 
      Germany) of the European Prospective Investigation into Cancer and Nutrition 
      (EPIC) study. A standardized 24-HDR software and a country/centre-specific 
      validated dietary questionnaire (DQ) were used to collect acute and habitual 
      dietary data, respectively. The intake of dietary flavonols was estimated using 
      the Phenol-Explorer database. Urinary flavonols (quercetin, isorhamnetin, and 
      kaempferol) were analysed using tandem mass spectrometry with a previous 
      enzymatic hydrolysis. RESULTS: Weak partial Spearman correlations between both 
      dietary acute and habitual intake and urinary concentrations of quercetin (both 
      R(partial) ~ 0.3) and total flavonols (both R(partial) ~ 0.2) were observed. No 
      significant correlations were found for kaempferol and isorhamentin. Regarding 
      flavonol-rich foods, weak correlations were found between urinary concentrations 
      of quercetin and total flavonols and the acute intake of onions and garlics, 
      fruits, tea, and herbal tea (all R(partial) ~ 0.2). For habitual intake, 
      statistically significant correlations were only found between urinary quercetin 
      concentration and herbal tea (R(partial) = 0.345) and between urinary total 
      flavonol concentration and tea, and herbal tea consumption (R(partial) ~ 0.2). 
      CONCLUSIONS: Our results suggest that urinary quercetin level can be used as 
      potential concentration biomarkers of both acute and habitual quercetin intake, 
      while urinary concentrations of flavonols are unlikely to be useful biomarkers of 
      individual flavonol-rich foods.
FAU - Garro-Aguilar, Yaiza
AU  - Garro-Aguilar Y
AUID- ORCID: 0000-0002-6236-6804
AD  - Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan 
      Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 
      Av Gran Via 199-203, L'Hospitalet de Llobregat, 08908, Barcelona, Spain.
FAU - Cayssials, Valerie
AU  - Cayssials V
AD  - Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan 
      Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 
      Av Gran Via 199-203, L'Hospitalet de Llobregat, 08908, Barcelona, Spain.
FAU - Achaintre, David
AU  - Achaintre D
AD  - International Agency for Research on Cancer (IARC-WHO), Lyon, France.
FAU - Boeing, Heiner
AU  - Boeing H
AD  - Department of Epidemiology, German Institute of Human Nutrition 
      Potsdam-Rehbruecke, Nuthetal, Germany.
FAU - Mancini, Francesca Romana
AU  - Mancini FR
AD  - CESP, Fac. de medecine-Univ. Paris-Sud, Fac. de medecine-UVSQ, INSERM, Universite 
      Paris-Saclay, Villejuif, France.
AD  - Institut Gustave Roussy, Villejuif, France.
FAU - Mahamat-Saleh, Yahya
AU  - Mahamat-Saleh Y
AD  - CESP, Fac. de medecine-Univ. Paris-Sud, Fac. de medecine-UVSQ, INSERM, Universite 
      Paris-Saclay, Villejuif, France.
AD  - Institut Gustave Roussy, Villejuif, France.
FAU - Boutron-Ruault, Marie-Christine
AU  - Boutron-Ruault MC
AD  - CESP, Fac. de medecine-Univ. Paris-Sud, Fac. de medecine-UVSQ, INSERM, Universite 
      Paris-Saclay, Villejuif, France.
AD  - Institut Gustave Roussy, Villejuif, France.
FAU - Kuhn, Tilman
AU  - Kuhn T
AD  - Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, 
      Germany.
FAU - Katzke, Verena
AU  - Katzke V
AD  - Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, 
      Germany.
FAU - Trichopoulou, Antonia
AU  - Trichopoulou A
AD  - Hellenic Health Foundation, Athens, Greece.
FAU - Karakatsani, Anna
AU  - Karakatsani A
AD  - Hellenic Health Foundation, Athens, Greece.
AD  - 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian 
      University of Athens, "ATTIKON" University Hospital, Haidari, Greece.
FAU - Thriskos, Paschalis
AU  - Thriskos P
AD  - Hellenic Health Foundation, Athens, Greece.
FAU - Masala, Giovanna
AU  - Masala G
AD  - Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer 
      Research, Prevention and Clinical Network-ISPRO, Florence, Italy.
FAU - Grioni, Sara
AU  - Grioni S
AD  - Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 
      Milan, Italy.
FAU - Santucci de Magistris, Maria
AU  - Santucci de Magistris M
AD  - AOU Federico II, Naples, Italy.
FAU - Tumino, Rosario
AU  - Tumino R
AD  - Cancer Regsitry and Histopathology Department, "M.P Arezzzo" Hospital, ASP 
      Ragusa, Italy.
FAU - Ricceri, Fulvio
AU  - Ricceri F
AD  - Department of Clinical and Biological Sciences, University of Turin, Turin, 
      Italy.
AD  - Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco, TO, Italy.
FAU - Huybrechts, Inge
AU  - Huybrechts I
AD  - International Agency for Research on Cancer (IARC-WHO), Lyon, France.
FAU - Agudo, Antonio
AU  - Agudo A
AD  - Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan 
      Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 
      Av Gran Via 199-203, L'Hospitalet de Llobregat, 08908, Barcelona, Spain.
FAU - Scalbert, Augustin
AU  - Scalbert A
AD  - International Agency for Research on Cancer (IARC-WHO), Lyon, France.
FAU - Zamora-Ros, Raul
AU  - Zamora-Ros R
AD  - Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan 
      Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 
      Av Gran Via 199-203, L'Hospitalet de Llobregat, 08908, Barcelona, Spain. 
      rzamora@idibell.cat.
LA  - eng
GR  - 001/WHO_/World Health Organization/International
PT  - Journal Article
DEP - 20190522
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Biomarkers)
RN  - 0 (Flavonols)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/urine
MH  - Diet/*methods
MH  - Europe
MH  - Female
MH  - Flavonols/*administration & dosage/*urine
MH  - Health Surveys/*methods/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
OTO - NOTNLM
OT  - Biomarker
OT  - EPIC
OT  - Flavonols
OT  - Quercetin
OT  - Urine
EDAT- 2019/05/24 06:00
MHDA- 2021/03/30 06:00
CRDT- 2019/05/24 06:00
PHST- 2019/01/31 00:00 [received]
PHST- 2019/05/16 00:00 [accepted]
PHST- 2019/05/24 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2019/05/24 06:00 [entrez]
AID - 10.1007/s00394-019-02005-5 [pii]
AID - 10.1007/s00394-019-02005-5 [doi]
PST - ppublish
SO  - Eur J Nutr. 2020 Jun;59(4):1481-1492. doi: 10.1007/s00394-019-02005-5. Epub 2019 
      May 22.