PMID- 31119516
OWN - NLM
STAT- MEDLINE
DCOM- 20200110
LR  - 20200225
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 51
IP  - 7
DP  - 2019 Jul
TI  - Association of serum IL-18 with protein-energy wasting in end-stage renal disease 
      patients on haemodialysis.
PG  - 1271-1278
LID - 10.1007/s11255-019-02167-5 [doi]
AB  - PURPOSE: Protein-energy wasting (PEW) is highly prevalent in end-stage renal 
      disease (ESRD) patients with inflammation who are on haemodialysis treatment. 
      Interleukin-18 (IL-18) is an important pro-inflammatory cytokine that is 
      significantly elevated in ESRD patients. However, the relationship between PEW 
      and IL-18 is unclear. We therefore performed a cross-sectional study on 100 ESRD 
      patients undergoing haemodialysis to clarify this. METHODS: PEW was defined 
      according to the diagnostic criteria of the International Society of Renal 
      Nutrition and Metabolism. Inflammation was assessed based on the serum levels of 
      C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) 
      and IL-18. We analysed the association between PEW and IL-18 by using logistic 
      analysis and linear regression after adjustment for basic characteristics, 
      comorbidities and laboratory findings. RESULTS: Among the 100 haemodialysis 
      patients who were recruited, 56 had PEW. Even though there was no difference 
      between the PEW group and non-PEW group with regard to disease causes, age, 
      gender, cholesterol, ferritin, and haemoglobin, the levels of inflammation 
      indicators such as CRP, IL-6, TNF-alpha and IL-1beta were significantly higher in the 
      PEW group. Moreover, IL-18 was found to contribute to PEW, but was negatively 
      correlated with pre-albumin after adjustment for possible confounding factors. 
      CONCLUSIONS: Thus, the findings indicate that IL-18 is associated with PEW in 
      ESRD patients on haemodialysis, which suggests that IL-18 may be involved in the 
      pathogenesis of PEW in this setting.
FAU - Bi, Xiao
AU  - Bi X
AD  - Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, 
      Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China.
FAU - Chu, Mingzi
AU  - Chu M
AD  - Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, 
      Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China.
FAU - Ai, Honglan
AU  - Ai H
AD  - Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, 
      Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China.
FAU - Hu, Chun
AU  - Hu C
AD  - Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, 
      Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China. 
      spring_115@hotmail.com.
FAU - Ding, Wei
AU  - Ding W
AD  - Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, 
      Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China. 
      gump1015@163.com.
LA  - eng
GR  - YG2017MS07/School of Medicine, Shanghai Jiao Tong University/
GR  - 17PJD021/Shanghai Science and Technology Development Foundation/
GR  - jyyq09201701/shanghai ninth people's hospital/
PT  - Journal Article
DEP - 20190522
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Biomarkers/blood
MH  - China/epidemiology
MH  - Correlation of Data
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Inflammation/blood
MH  - Interleukin-18/*blood
MH  - *Kidney Failure, Chronic/blood/complications/diagnosis/therapy
MH  - Male
MH  - Middle Aged
MH  - Nutrition Assessment
MH  - *Protein-Energy Malnutrition/blood/diagnosis/etiology
MH  - *Renal Dialysis/adverse effects/methods
MH  - Serum Albumin/*analysis
OTO - NOTNLM
OT  - IL-18
OT  - Pre-albumin
OT  - Protein-energy wasting
EDAT- 2019/05/24 06:00
MHDA- 2020/01/11 06:00
CRDT- 2019/05/24 06:00
PHST- 2018/12/24 00:00 [received]
PHST- 2019/05/02 00:00 [accepted]
PHST- 2019/05/24 06:00 [pubmed]
PHST- 2020/01/11 06:00 [medline]
PHST- 2019/05/24 06:00 [entrez]
AID - 10.1007/s11255-019-02167-5 [pii]
AID - 10.1007/s11255-019-02167-5 [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2019 Jul;51(7):1271-1278. doi: 10.1007/s11255-019-02167-5. Epub 
      2019 May 22.