PMID- 31122714 OWN - NLM STAT- MEDLINE DCOM- 20200608 LR - 20200608 IS - 1365-229X (Electronic) IS - 0009-9260 (Linking) VI - 74 IP - 9 DP - 2019 Sep TI - Myocardial extracellular volume fraction measurements with MOLLI 5(3)3 by cardiovascular MRI for the discrimination of healthy volunteers from dilated and hypertrophic cardiomyopathy patients. PG - 732.e9-732.e16 LID - S0009-9260(19)30214-4 [pii] LID - 10.1016/j.crad.2019.04.019 [doi] AB - AIM: To investigate the diagnostic performance of myocardial native T1 time and the extracellular volume fraction (ECV) for differentiating dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) patients from healthy volunteers. MATERIALS AND METHODS: Forty healthy volunteers, 57 DCM patients, and 30 HCM patients were enrolled, all of whom underwent cardiovascular magnetic resonance imaging (CMRI), including late gadolinium enhancement (LGE) and native and post-contrast T1 mapping acquired with the modified Look-Locker inversion recovery (MOLLI) sequence on a 1.5 T MRI system. ECV were calculated by native and post-contrast T1 times. Multivariate binary logistic regression analyses and receiver operating characteristic (ROC) curve analyses were used to assess the concordance with the clinical diagnosis of DCM and HCM. RESULTS: DCM and HCM patients had significantly higher myocardial native T1 times and ECVs than healthy volunteers (p<0.001). Multivariate logistic regression analyses showed that ECV was an independent predictor of DCM and HCM diagnosis (OR=1.556, p<0.001 and OR=1.847, p=0.001, respectively). ROC curve analysis indicated that ECV provided greater distinction between DCM patients and healthy volunteers than native T1 time (AUC: 0.889 versus 0.780, p=0.021). At the optimal cut-off value, ECV identified DCM and HCM patients with 80.7% and 83.3% sensitivity, 87.5% and 70% specificity, 90.2% and 67.6% positive predictive value, and 76.1% and 84.8% negative predictive value, respectively. CONCLUSION: The increased ECV in DCM and HCM patients reflects myocardial extracellular matrix expansion. Myocardial ECV provides good diagnostic performance for identifying DCM and HCM patients from healthy volunteers. CI - Copyright (c) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. FAU - Cui, Y AU - Cui Y AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. FAU - Chen, Y AU - Chen Y AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. FAU - Cao, Y AU - Cao Y AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. FAU - Liu, J AU - Liu J AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. FAU - Song, J AU - Song J AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. FAU - Zhang, S AU - Zhang S AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. FAU - Kong, X AU - Kong X AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. FAU - Han, P AU - Han P AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. Electronic address: cjr.hanping@vip.163.com. FAU - Shi, H AU - Shi H AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. Electronic address: heshuishi@hust.edu.cn. LA - eng PT - Journal Article DEP - 20190520 PL - England TA - Clin Radiol JT - Clinical radiology JID - 1306016 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Cardiomyopathy, Dilated/*diagnostic imaging MH - Cardiomyopathy, Hypertrophic/*diagnostic imaging MH - Contrast Media MH - Diagnosis, Differential MH - Female MH - Gadolinium DTPA MH - *Healthy Volunteers MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Myocardium/*pathology MH - Sensitivity and Specificity EDAT- 2019/05/28 06:00 MHDA- 2020/06/09 06:00 CRDT- 2019/05/25 06:00 PHST- 2018/07/10 00:00 [received] PHST- 2019/04/18 00:00 [accepted] PHST- 2019/05/28 06:00 [pubmed] PHST- 2020/06/09 06:00 [medline] PHST- 2019/05/25 06:00 [entrez] AID - S0009-9260(19)30214-4 [pii] AID - 10.1016/j.crad.2019.04.019 [doi] PST - ppublish SO - Clin Radiol. 2019 Sep;74(9):732.e9-732.e16. doi: 10.1016/j.crad.2019.04.019. Epub 2019 May 20.