PMID- 31123651
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 11
IP  - 3
DP  - 2019 Mar 11
TI  - The Role of Cardiac Magnetic Resonance Imaging in Severe Anorexia Nervosa.
PG  - e4229
LID - 10.7759/cureus.4229 [doi]
LID - e4229
AB  - Objective Anorexia nervosa (AN) patients are at an increased risk of developing 
      cardiac complications including bradyarrhythmias, systolic dysfunction, 
      pericardial effusions, and sudden cardiac death. Although previous 
      echocardiographic studies in AN patients have demonstrated a reduction in overall 
      left ventricular (LV) mass, systolic dysfunction, and silent pericardial 
      effusions, little is known about the role of cardiac magnetic resonance imaging 
      (CMR) in assessing this patient population. The objective of this study was to 
      assess cardiac indices and the presence of myocardial fibrosis in AN patients. 
      Methods Between 2014 and 2015, a cross-sectional pilot study of 16 female 
      patients who met the Diagnostic and Statistics Manual of Mental Disorders, fifth 
      edition (DSM-5) criteria for AN was conducted at a single tertiary care center. 
      Baseline characteristics including age, weight, food restriction behavior, 
      over-exercise, self-induced vomiting, and laxative abuse were collected in the 
      study population. Electrocardiography, transthoracic echocardiography (TTE), and 
      CMR were performed. Results The mean age was 17 years (range: 13-22 years). There 
      were no conduction abnormalities as the average PR interval was 152 ms (range: 
      130-190 ms) and QTc was 413 ms (range: 360-450 ms). Using TTE, the left 
      ventricular ejection fraction (LVEF) was 54 +/- 4% with a lower LV mass/body 
      surface area (BSA) of 56 +/- 7g/m(2 )in AN patients as compared to controls. Using 
      CMR, both the mean LVEF of 52 +/- 9% and LV mass/BSA of 45 +/- 4g/m(2 )were lower in 
      AN patients as compared to controls. Using CMR, both right ventricular ejection 
      fraction (RVEF) of 50 +/- 10% and a right ventricular (RV) mass/BSA of 18 +/- 
      3g/m(2 )were smaller in AN patients as compared to controls. There was no 
      evidence of late gadolinium enhancement (LGE) in the study population. 
      Conclusions Young patients with AN have lower cardiac mass and volumes with no 
      evidence of myocardial fibrosis.
FAU - Chu, Karen
AU  - Chu K
AD  - Internal Medicine, University of Manitoba, Winnipeg, CAN.
FAU - Asselin, Chantal Y
AU  - Asselin CY
AD  - Cardiology, University of Manitoba, Winnipeg, CAN.
FAU - Buffo, Ilan
AU  - Buffo I
AD  - Pediatrics, University of Manitoba, Winnipeg, CAN.
FAU - Lane, Margo
AU  - Lane M
AD  - Psychiatry, University of Manitoba, Winnipeg, CAN.
FAU - Ludwig, Louis
AU  - Ludwig L
AD  - Psychiatry, University of Manitoba, Winnipeg, CAN.
FAU - Jassal, Davinder S
AU  - Jassal DS
AD  - Internal Medicine, University of Manitoba, Winnipeg, CAN.
FAU - Schantz, Daryl
AU  - Schantz D
AD  - Pediatrics, University of Manitoba, Winnipeg, CAN.
LA  - eng
PT  - Journal Article
DEP - 20190311
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC6510561
OTO - NOTNLM
OT  - anorexia nervosa
OT  - cardiac magnetic resonance imaging
OT  - cardiovascular remodelling
OT  - transthoracic echocardiography
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/05/28 06:00
MHDA- 2019/05/28 06:01
PMCR- 2019/03/11
CRDT- 2019/05/25 06:00
PHST- 2019/05/25 06:00 [entrez]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2019/05/28 06:01 [medline]
PHST- 2019/03/11 00:00 [pmc-release]
AID - 10.7759/cureus.4229 [doi]
PST - epublish
SO  - Cureus. 2019 Mar 11;11(3):e4229. doi: 10.7759/cureus.4229.