PMID- 31123860
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 267
IP  - 12
DP  - 2020 Dec
TI  - The effect of transcranial direct current stimulation on upper limb motor 
      performance in Parkinson's disease: a systematic review.
PG  - 3479-3488
LID - 10.1007/s00415-019-09385-y [doi]
AB  - BACKGROUND AND PURPOSE: Parkinson's disease (PD) reduces independence and quality 
      of life through deterioration of upper limb motor function. Transcranial direct 
      current stimulation (tDCS) may offer an alternative, adjunctive therapy for PD. 
      However, the efficacy of tDCS for upper limb motor rehabilitation in PD is 
      unknown. In this systematic review, evidence is compiled regarding the effects of 
      tDCS on upper limb motor function in PD. METHODS: Studies of tDCS applied to PD 
      patients that assessed upper limb motor function, conducted between January 2000 
      and November 2018, were screened for inclusion via a systematic search of 
      Medline, Cochrane, PsycINFO, EMBASE, CINAHL, and Web of Science. RESULTS: Ten out 
      of 606 studies were included and their findings synthesized into five categories 
      regarding the effects of tDCS on: (1) Unified Parkinson's Disease Rating Scale 
      motor section (UPDRS III), (2) upper limb motor tasks, (3) manual dexterity, (4) 
      reaction time, and (5) neurophysiology. CONCLUSIONS: When applied to the primary 
      motor cortex, tDCS may improve UPDRS III and the speed and force of movement. 
      Considerable variation was found in tDCS parameters and further study is needed 
      to clarify the long-term effects of tDCS on both simple and complex motor tasks 
      and to compile relevant neurophysiological evidence.
FAU - Simpson, Michael William
AU  - Simpson MW
AUID- ORCID: 0000-0002-9086-4384
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung 
      Hom, Hong Kong.
FAU - Mak, Margaret
AU  - Mak M
AUID- ORCID: 0000-0002-2461-9962
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung 
      Hom, Hong Kong. Margaret.Mak@polyu.edu.hk.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20190523
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Humans
MH  - *Motor Cortex
MH  - *Parkinson Disease/therapy
MH  - Quality of Life
MH  - *Transcranial Direct Current Stimulation
MH  - Upper Extremity
OTO - NOTNLM
OT  - Motor function
OT  - Parkinson's disease
OT  - Upper limb
OT  - tDCS
EDAT- 2019/05/28 06:00
MHDA- 2021/06/22 06:00
CRDT- 2019/05/25 06:00
PHST- 2019/02/19 00:00 [received]
PHST- 2019/05/16 00:00 [accepted]
PHST- 2019/05/14 00:00 [revised]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/05/25 06:00 [entrez]
AID - 10.1007/s00415-019-09385-y [pii]
AID - 10.1007/s00415-019-09385-y [doi]
PST - ppublish
SO  - J Neurol. 2020 Dec;267(12):3479-3488. doi: 10.1007/s00415-019-09385-y. Epub 2019 
      May 23.