PMID- 31124320
OWN - NLM
STAT- MEDLINE
DCOM- 20200618
LR  - 20210109
IS  - 2324-9269 (Electronic)
IS  - 2324-9269 (Linking)
VI  - 7
IP  - 7
DP  - 2019 Jul
TI  - Association study between matrix metalloproteinase-3 gene (MMP3) polymorphisms 
      and ankylosing spondylitis susceptibility.
PG  - e00752
LID - 10.1002/mgg3.752 [doi]
LID - e00752
AB  - BACKGROUND: Ankylosing spondylitis (AS) is the second most common cause of 
      inflammatory arthritis worldwide affecting the axial skeleton. Single nucleotide 
      polymorphisms (SNPs) of matrix metalloproteinase-3 (MMP3) in the development of 
      AS has few been investigated in Chinese population. METHODS: A total of 362 
      patients with AS and 362 healthy controls were enrolled in the study. Five SNPs 
      in MMP3 genotypes were identified by Agena MassARRAY. Chi-squared tests and 
      genetic model were used to evaluate associations. RESULTS: rs522616 had a 
      significant risk of AS development compared to those with the TT genotype 
      (p = 0.008). By multiple logistic regression models analysis, in codominant 
      model, rs522616 CT genotypes also had a 1.44-fold risk (95% CI = 1.06-1.96, 
      p = 0.008) for AS development compared to those with TT genotypes. In recessive 
      model, the CC genotypes was a significantly reduced AS risk for individuals with 
      TT/CT genotype (OR = 0.64; 95% CI = 0.41-0.99, p = 0.040). CONCLUSION: The 
      present study suggests that MMP3 rs522616 polymorphism is associated with AS 
      susceptibility and MMP3 might be a potential diagnostic biomarker for AS. Further 
      independent studies with larger cohorts are warranted to validate our findings in 
      different populations.
CI  - (c) 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley 
      Periodicals, Inc.
FAU - Zhu, Yong
AU  - Zhu Y
AUID- ORCID: 0000-0002-8840-686X
AD  - The Second Affiliated Hospital of Inner, Mongolia Medical University, Hohhot, 
      China.
FAU - Li, Shunan
AU  - Li S
AD  - The Hohhot First Hospital, Hohhot, China.
FAU - Huang, Zhi
AU  - Huang Z
AD  - The Second Affiliated Hospital of Inner, Mongolia Medical University, Hohhot, 
      China.
FAU - Xing, Wenhua
AU  - Xing W
AD  - The Second Affiliated Hospital of Inner, Mongolia Medical University, Hohhot, 
      China.
FAU - Li, Feng
AU  - Li F
AD  - The Second Affiliated Hospital of Inner, Mongolia Medical University, Hohhot, 
      China.
FAU - Da, Yifeng
AU  - Da Y
AD  - Inner Mongolia Medical University, Hohhot, China.
FAU - Xue, Jianmin
AU  - Xue J
AD  - Inner Mongolia Medical University, Hohhot, China.
FAU - Li, Manglai
AU  - Li M
AD  - Inner Mongolia Medical University, Hohhot, China.
FAU - Sun, Ke
AU  - Sun K
AD  - Inner Mongolia Medical University, Hohhot, China.
FAU - Jia, Haiyu
AU  - Jia H
AD  - The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
FAU - Yang, Xuejun
AU  - Yang X
AUID- ORCID: 0000-0003-2713-7237
AD  - The Second Affiliated Hospital of Inner, Mongolia Medical University, Hohhot, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190523
PL  - United States
TA  - Mol Genet Genomic Med
JT  - Molecular genetics & genomic medicine
JID - 101603758
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - China
MH  - Humans
MH  - Matrix Metalloproteinase 3/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Spondylitis, Ankylosing/*genetics
PMC - PMC6625098
OTO - NOTNLM
OT  - Ankylosing spondylitis (AS)
OT  - Chinese population
OT  - Single nucleotide polymorphisms (SNPs)
OT  - matrix metalloproteinase3 (MMP3)
COIS- The authors have declared that they have no conflict of interest.
EDAT- 2019/05/28 06:00
MHDA- 2020/06/19 06:00
PMCR- 2019/05/23
CRDT- 2019/05/25 06:00
PHST- 2019/02/16 00:00 [received]
PHST- 2019/04/22 00:00 [revised]
PHST- 2019/04/27 00:00 [accepted]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2020/06/19 06:00 [medline]
PHST- 2019/05/25 06:00 [entrez]
PHST- 2019/05/23 00:00 [pmc-release]
AID - MGG3752 [pii]
AID - 10.1002/mgg3.752 [doi]
PST - ppublish
SO  - Mol Genet Genomic Med. 2019 Jul;7(7):e00752. doi: 10.1002/mgg3.752. Epub 2019 May 
      23.