PMID- 31126271 OWN - NLM STAT- MEDLINE DCOM- 20191211 LR - 20200225 IS - 1471-2466 (Electronic) IS - 1471-2466 (Linking) VI - 19 IP - 1 DP - 2019 May 24 TI - Factors affecting survival in patients with endobronchial malignant mass after flexible Bronchoscopic cryotherapy: a cohort study. PG - 101 LID - 10.1186/s12890-019-0854-2 [doi] LID - 101 AB - BACKGROUND: Malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly to diagnose MEM, however, the therapeutic role of cryotherapy impacts on survival has not be well addressed. METHODS: Cohort data on post-cryotherapy MEM patients in a university-affiliated hospital between 2007 and 2012 were evaluated. Factors that impact survival of these subjects were analyzed using multivariate regression analysis. RESULTS: During study period, 67 patients (47 males), with median age was 63 years (range, 50-77 and median performance status of 2 (inter-quartile range [IQR], 2-3). Twenty-five had primary lung squamous cell carcinoma, 14 primary had lung adenocarcinoma, seven had metastatic colon adenocarcinoma, four had sarcoma, four had non-small cell lung cancer, four had small cell lung cancer, three had large cell carcinoma, two had lymphoma, one had muco-epidermoid carcinoma, two had esophageal squamous cell carcinoma, and one had metastatic renal cell carcinoma. MEM were observed as follows: 15 at the trachea, 14 at the left main bronchus, 12 at the right main bronchus, 12 at the right upper lobe bronchus, five at the right intermediate bronchus, three at the right lower lobe bronchus, three at the left upper lobe bronchus, two at the left lower lobe bronchus, and one at the right middle lobe bronchus Post-cryotherapy complications included minor bleeding (n = 14) and need for multiple procedures (n = 12); outcomes were relief of symptoms (n = 56), improved performance status (n = 49) and ability to receive chemotherapy (n = 43). After controlling for other variables, performance status improved after cryotherapy (odds ratio [OR] 3.7; p = 0.03; 95% confidence interval [CI] 1.2~10.7) and ability to receive chemotherapy (OR 4.3; p = 0.02; 95% CI 1.4~13.7) remained significant survival factor. Patients who received chemotherapy and cryotherapy had better survival than patients who received only cryotherapy (median, 472 vs. 169 days; log-rank test, p = 0.02; HR 0.37; 95% CI 0.16-0.89). CONCLUSION: Cryotherapy could be useful management of MEM by flexible bronchoscopy. The performance status after cryotherapy improved and caused further chemotherapy possible for the study patients and thereby, improved survival. However, the mechanism in detail of cryotherapy improve survival should be explored in the future. FAU - Chung, Fu-Tsai AU - Chung FT AUID- ORCID: 0000-0001-9749-0111 AD - Department of Thoracic Medicine, Saint Paul's Hospital, Taoyuan, Taiwan. vikingchung@yahoo.com.tw. AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. vikingchung@yahoo.com.tw. AD - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan City, Taiwan. vikingchung@yahoo.com.tw. AD - Department of Thoracic Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. vikingchung@yahoo.com.tw. FAU - Chou, Chun-Liang AU - Chou CL AD - Department of Thoracic Medicine, Saint Paul's Hospital, Taoyuan, Taiwan. AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. AD - Department of Thoracic Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. FAU - Lo, Yu-Lun AU - Lo YL AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. FAU - Kuo, Chih-Hsi AU - Kuo CH AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. FAU - Wang, Tsai-Yu AU - Wang TY AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. FAU - Wang, Chun-Hwa AU - Wang CH AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. FAU - Huang, Hung-Yu AU - Huang HY AD - Department of Thoracic Medicine, Saint Paul's Hospital, Taoyuan, Taiwan. AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. FAU - Lin, Horng-Chyuan AU - Lin HC AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. FAU - Chang, Chih-Hao AU - Chang CH AD - Department of Thoracic Medicine, Saint Paul's Hospital, Taoyuan, Taiwan. AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. FAU - Lee, Chung-Shu AU - Lee CS AD - Department of Thoracic Medicine, Saint Paul's Hospital, Taoyuan, Taiwan. AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. FAU - Chen, Hao-Cheng AU - Chen HC AD - Department of Thoracic Medicine, Saint Paul's Hospital, Taoyuan, Taiwan. AD - Department of Thoracic Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei, Taiwan. FAU - Lin, Shu-Min AU - Lin SM AD - Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan. smlin100@gmail.com. LA - eng PT - Journal Article DEP - 20190524 PL - England TA - BMC Pulm Med JT - BMC pulmonary medicine JID - 100968563 SB - IM MH - Aged MH - Bronchoscopy MH - *Cryotherapy MH - Drug Therapy MH - Female MH - Humans MH - Logistic Models MH - Lung Neoplasms/*mortality/*pathology/*therapy MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Survival Rate MH - Taiwan PMC - PMC6533732 OTO - NOTNLM OT - Chemotherapy OT - Cohort OT - Cryotherapy OT - Malignant endobronchial mass OT - Survival COIS- The authors declare that they have no competing interests. EDAT- 2019/05/28 06:00 MHDA- 2019/12/18 06:00 PMCR- 2019/05/24 CRDT- 2019/05/26 06:00 PHST- 2018/06/19 00:00 [received] PHST- 2019/04/26 00:00 [accepted] PHST- 2019/05/26 06:00 [entrez] PHST- 2019/05/28 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/05/24 00:00 [pmc-release] AID - 10.1186/s12890-019-0854-2 [pii] AID - 854 [pii] AID - 10.1186/s12890-019-0854-2 [doi] PST - epublish SO - BMC Pulm Med. 2019 May 24;19(1):101. doi: 10.1186/s12890-019-0854-2.