PMID- 31128861
OWN - NLM
STAT- MEDLINE
DCOM- 20200213
LR  - 20200213
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 40
IP  - 5
DP  - 2019 Sep-Oct
TI  - Aberrant expressed long non-coding RNAs in laryngeal squamous-cell carcinoma.
PG  - 615-625
LID - S0196-0709(19)30050-X [pii]
LID - 10.1016/j.amjoto.2019.05.002 [doi]
AB  - PURPOSE: Laryngeal squamous-cell carcinoma (LSCC) is the second most common 
      malignant tumor of head and neck squamous cell carcinoma. The study was aimed to 
      identify key long non-coding RNAs (lncRNAs) biomarkers for LSCC. METHODS: 
      Differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) between LSCC and 
      adjacent tissues were obtained based on The Cancer Genome Atlas. DElncRNA-DEmRNAs 
      co-expression and DElncRNA-nearby-target DEmRNA interaction networks were 
      constructed. Receiver operating characteristic and survival analysis were 
      performed. A published dataset were as used to validate the result of 
      bioinformatics analysis. RESULTS: We obtained 1103 DEmRNAs and 306 DElncRNAs 
      between LSCC and adjacent tissues. A total of 338 DElncRNA-DEmRNA co-expression 
      pairs and 229 DElncRNA-nearby-target DEmRNA pairs were obtained. Ten DElncRNAs 
      and six DEmRNAs has great diagnostic value for LSCC. HOXB9 has potential 
      prognostic value for LSCC. The results of GSE84957 validation were generally 
      consistent with our results. CONCLUSION: Our study provided clues for 
      understanding the mechanism and developing potential biomarkers for LSCC.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Li, Hu
AU  - Li H
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong, China.
FAU - Wang, Fu-Ling
AU  - Wang FL
AD  - Department of Obstetrics, Maternal and Child Health Hospital of RenCheng 
      District, Jining, Jining, Shandong, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong, China.
FAU - Fei, Yong-Hua
AU  - Fei YH
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong, China.
FAU - Wang, Ya-Ting
AU  - Wang YT
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong, China.
FAU - Zhang, Jing-E
AU  - Zhang JE
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong, China.
FAU - Bi, Hui-Yun
AU  - Bi HY
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong, China.
FAU - Zhang, Mei
AU  - Zhang M
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong, China. Electronic address: zhangmei_doctor@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190509
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Computational Biology
MH  - Databases, Factual
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Gene Regulatory Networks
MH  - Genome, Human
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/mortality
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
MH  - RNA, Messenger/*genetics
MH  - Reproducibility of Results
MH  - Squamous Cell Carcinoma of Head and Neck/*genetics/mortality/pathology
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma (LSCC)
OT  - Long non-coding RNAs (lncRNAs)
OT  - The Cancer Genome Atlas (TCGA)
OT  - mRNA
EDAT- 2019/05/28 06:00
MHDA- 2020/02/14 06:00
CRDT- 2019/05/27 06:00
PHST- 2019/01/23 00:00 [received]
PHST- 2019/05/08 00:00 [accepted]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2020/02/14 06:00 [medline]
PHST- 2019/05/27 06:00 [entrez]
AID - S0196-0709(19)30050-X [pii]
AID - 10.1016/j.amjoto.2019.05.002 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2019 Sep-Oct;40(5):615-625. doi: 10.1016/j.amjoto.2019.05.002. 
      Epub 2019 May 9.