PMID- 31129564
OWN - NLM
STAT- MEDLINE
DCOM- 20200331
LR  - 20200331
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 104
IP  - 11
DP  - 2019 Nov
TI  - Association between early life (prenatal and postnatal) antibiotic administration 
      and coeliac disease: a systematic review.
PG  - 1083-1089
LID - 10.1136/archdischild-2019-317174 [doi]
AB  - OBJECTIVE: Whether prenatal or postnatal exposure to antibiotics is associated 
      with an increased risk of coeliac disease (CD) is unclear. We systematically 
      reviewed studies on the association between early life antibiotic exposure and 
      the risk of CD or CD autoimmunity. DESIGN: Systematic review of observational 
      studies. DATA SOURCES: The PubMed and Embase databases were searched up to 
      December 2018, with no language restrictions. Additional references were obtained 
      from reviewed articles. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Cohort, 
      cross-sectional and case-control studies that assessed the association between 
      prenatal and/or postnatal antibiotic exposure and the odds of developing CD (as 
      defined by authors of the original studies) or CD autoimmunity were eligible for 
      inclusion. RESULTS: Six studies were included. In two large cohort studies that 
      focused on prenatal antibiotic exposure, no association with the risk of CD was 
      found (adjusted OR=1.16; 95% CI 0.94 to 1.43 and adjusted HR=1.33; 95% CI 0.69 to 
      2.56) in the Norwegian and Swedish cohorts, respectively. In three studies that 
      evaluated the association of postnatal antibiotic exposure with the risk of CD, 
      the results were contradictory, with only the Italian cohort study reporting a 
      significant positive association (adjusted incidence rate ratio=1.24; 95% CI 1.07 
      to 1.43). A large, multicentre cohort study that evaluated the association 
      between postnatal antibiotic exposure and CD autoimmunity in human leukocyte 
      antigen (HLA)-positive subjects found no association. CONCLUSIONS: We found no 
      evidence of an association between prenatal or postnatal antibiotic exposure and 
      CD.
CI  - (c) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Kolodziej, Maciej
AU  - Kolodziej M
AUID- ORCID: 0000-0001-8123-2126
AD  - Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
FAU - Patro-Golab, Bernadeta
AU  - Patro-Golab B
AD  - Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
FAU - Gieruszczak-Bialek, Dorota
AU  - Gieruszczak-Bialek D
AD  - Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
FAU - Skorka, Agata
AU  - Skorka A
AD  - Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
FAU - Piescik-Lech, Malgorzata
AU  - Piescik-Lech M
AD  - Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
FAU - Baron, Ruth
AU  - Baron R
AD  - Division Youth and Lifestyle, Vrije Universiteit Amsterdam - Sarphati Amsterdam, 
      Amsterdam, The Netherlands.
FAU - Szajewska, Hania
AU  - Szajewska H
AD  - Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
CN  - behalf of the SAWANTI Working Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20190525
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/*administration & dosage/adverse effects
MH  - Celiac Disease/*etiology
MH  - Female
MH  - Humans
MH  - Observational Studies as Topic
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*drug therapy/microbiology
MH  - Prenatal Exposure Delayed Effects/*microbiology
MH  - Risk Factors
OTO - NOTNLM
OT  - antibiotics
OT  - celiac disease
OT  - children
OT  - prenatal
OT  - systematic review
COIS- Competing interests: None declared.
FIR - Baron, Ruth
IR  - Baron R
FIR - Der Vaart, Isolde Besseling-van
IR  - Der Vaart IB
FIR - Gieruszczak-Bialek, Dorota
IR  - Gieruszczak-Bialek D
FIR - Horvath, Andrea
IR  - Horvath A
FIR - Lukasik, Jan
IR  - Lukasik J
FIR - Kolodziej, Maciej
IR  - Kolodziej M
FIR - Patro-Golab, Bernadeta
IR  - Patro-Golab B
FIR - Piescik-Lech, Malgorzata
IR  - Piescik-Lech M
FIR - Seidell, Jaap
IR  - Seidell J
FIR - Skorka, Agata
IR  - Skorka A
FIR - Szajewska, Hania
IR  - Szajewska H
FIR - Taye, Meron
IR  - Taye M
FIR - Ujcic, Joanne
IR  - Ujcic J
FIR - Verhoeff, And Arnoud
IR  - Verhoeff AA
EDAT- 2019/05/28 06:00
MHDA- 2020/04/01 06:00
CRDT- 2019/05/27 06:00
PHST- 2019/03/06 00:00 [received]
PHST- 2019/04/29 00:00 [revised]
PHST- 2019/04/30 00:00 [accepted]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2020/04/01 06:00 [medline]
PHST- 2019/05/27 06:00 [entrez]
AID - archdischild-2019-317174 [pii]
AID - 10.1136/archdischild-2019-317174 [doi]
PST - ppublish
SO  - Arch Dis Child. 2019 Nov;104(11):1083-1089. doi: 
      10.1136/archdischild-2019-317174. Epub 2019 May 25.