PMID- 31130918
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 10
DP  - 2019
TI  - Mechanisms Involved in Childhood Obesity-Related Bone Fragility.
PG  - 269
LID - 10.3389/fendo.2019.00269 [doi]
LID - 269
AB  - Childhood obesity is one of the major health problems in western countries. The 
      excessive accumulation of adipose tissue causes inflammation, oxidative stress, 
      apoptosis, and mitochondrial dysfunctions. Thus, obesity leads to the development 
      of severe co-morbidities including type 2 diabetes mellitus, liver steatosis, 
      cardiovascular, and neurodegenerative diseases which can develop early in life. 
      Furthermore, obese children have low bone mineral density and a greater risk of 
      osteoporosis and fractures. The knowledge about the interplay bone tissue and 
      between adipose is still growing, although recent findings suggest that adipose 
      tissue activity on bone can be fat-depot specific. Obesity is associated to a 
      low-grade inflammation that alters the expression of adiponectin, leptin, IL-6, 
      Monocyte Chemotactic Protein 1 (MCP1), TRAIL, LIGHT/TNFSF14, OPG, and TNFalpha. These 
      molecules can affect bone metabolism, thus resulting in osteoporosis. The purpose 
      of this review was to deepen the cellular mechanisms by which obesity may 
      facilitate osteoporosis and bone fractures.
FAU - Faienza, Maria Felicia
AU  - Faienza MF
AD  - Department of Biomedical Sciences and Human Oncology, University of Bari Aldo 
      Moro, Bari, Italy.
FAU - D'Amato, Gabriele
AU  - D'Amato G
AD  - Neonatal Intensive Care Unit, Di Venere Hospital, Bari, Italy.
FAU - Chiarito, Mariangela
AU  - Chiarito M
AD  - Department of Biomedical Sciences and Human Oncology, University of Bari Aldo 
      Moro, Bari, Italy.
FAU - Colaianni, Graziana
AU  - Colaianni G
AD  - Department of Emergency and Organ Transplantation, Section of Human Anatomy and 
      Histology, University of Bari, Bari, Italy.
FAU - Colucci, Silvia
AU  - Colucci S
AD  - Department of Basic and Medical Sciences, Neurosciences and Sense Organs, Section 
      of Human Anatomy and Histology, University of Bari Aldo Moro, Bari, Italy.
FAU - Grano, Maria
AU  - Grano M
AD  - Department of Emergency and Organ Transplantation, Section of Human Anatomy and 
      Histology, University of Bari, Bari, Italy.
FAU - Corbo, Filomena
AU  - Corbo F
AD  - Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy.
FAU - Brunetti, Giacomina
AU  - Brunetti G
AD  - Department of Basic and Medical Sciences, Neurosciences and Sense Organs, Section 
      of Human Anatomy and Histology, University of Bari Aldo Moro, Bari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190503
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6509993
OTO - NOTNLM
OT  - cytokines
OT  - low grade inflammation
OT  - osteoclast
OT  - osteoimmunology
OT  - osteoporosis
EDAT- 2019/05/28 06:00
MHDA- 2019/05/28 06:01
PMCR- 2019/01/01
CRDT- 2019/05/28 06:00
PHST- 2019/01/02 00:00 [received]
PHST- 2019/04/11 00:00 [accepted]
PHST- 2019/05/28 06:00 [entrez]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2019/05/28 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2019.00269 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2019 May 3;10:269. doi: 10.3389/fendo.2019.00269. 
      eCollection 2019.